Professor | Chang Chen | Asia Growth Partners

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Name	Chang Chen
Contact Information	changchen@moon.ibp.ac.cn
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Chang Chen

Contact Information

changchen@moon.ibp.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1993-09 to 1996-06 Ph.D. in Science: Peking University 1990-09 to 1993-06 M.Sc. in Science: Beijing Normal University 1986-09 to 1990-06 B.Sc. in Science: Nankai University

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1993-09 to 1996-06 Ph.D. in Science: Peking University
1990-09 to 1993-06 M.Sc. in Science: Beijing Normal University
1986-09 to 1990-06 B.Sc. in Science: Nankai University

Areas of Focus	Protein thiol modification Nitric oxide Tumor and neurological disease-related targets Aging and regulation
Publications	Biomarkers of aging, Bao, Hainan, Cao, Jiani, Chen, Mengting, Chen, Min, Chen, Wei, Chen, Xiao, Chen, Yanhao, Chen, Yu, Chen, Yutian, Chen, Zhiyang, Chhetri, Jagadish K, Ding, Yingjie, Feng, Junlin, Guo, Jun, Guo, Mengmeng, He, Chuting, Jia, Yujuan, Jiang, Haiping, Jing, Ying, Li, Dingfeng, Li, Jiaming, Li, Jingyi, Liang, Qinhao, Liang, Rui, Liu, Feng, Liu, Xiaoqian, Liu, Zuojun, Luo, Oscar Junhong, Lv, Jianwei, Ma, Jingyi, Mao, Kehang, Nie, Jiawei, Qiao, Xinhua, Sun, Xinpei, Tang, Xiaoqiang, Wang, Jianfang, Wang, Qiaoran, Wang, Siyuan, Wang, Xuan, Wang, Yaning, Wang, Yuhan, Wu, Rimo, Xia, Kai, Xiao, FuHui, Xu, Lingyan, Xu, Yingying, Yan, Haoteng, Yang, Liang, Yang, Ruici, Yang, Yuanxin, Ying, Yilin, Zhang, Le, Zhang, Weiwei, Zhang, Wenwan, Zhang, Xing, Zhang, Zhuo, Zhou, Min, Zhou, Rui, Zhu, Qingchen, Zhu, Zhengmao, Cao, Feng, Cao, Zhongwei, Chan, Piu, Chen, Chang, Chen, Guobing, Chen, HouZao, Chen, Jun, Ci, Weimin, Ding, BiSen, Ding, Qiurong, Gao, Feng, Han, JingDong J, Huang, Kai, Ju, Zhenyu, Kong, Qing, 2023 Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, Miaomiao Guo, Xinhua Qiao, Yuanyuan Wang, ZiHan Li, Chang Shi, Yun Chen, Lu Kang, Chang Chen, XiaoLong Zhou, 2023 Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis, Chang Chen, 2023 LBP1C-2 from Lycium barbarum maintains skeletal muscle satellite cell pool by interaction with FGFR1, Jiao Meng, Zhenyu Lv, Xia Chen, Chuanxin Sun, Can Jin, Kan Ding, Chang Chen, 2023 Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells, Jiao Meng, Yuanyuan Wang, Zhenyu Lv, Xinhua Qiao, Qiaoli Zhu, Chang Chen, 2023 Multi-Omics Approach Reveals Redox Homeostasis Reprogramming in Early-Stage Clear Cell Renal Cell Carcinoma, Zhang, Wei, Qiao, Xinhua, Xie, Ting, Cai, Wenbin, Zhang, Xu, Chen, Chang, Zhang, Yaoguang, 2023 LBP1C-2 from Lycium barbarum alleviated age-related bone loss by targeting BMPRIA/BMPRII/Noggin, Sun, Chuanxin, Chen, Xia, Yang, Shangpo, Jin, Can, Ding, Kan, Chen, Chang, 2023 Exploring the precision redox map during fasting-refeeding and satiation in C. elegans, Xinhua Qiao, Lu Kang, Chang Shi, Aojun Ye, Dongli Wu, Yuyunfei Huang, Minghao Deng, Jiarui Wang, Yuzheng Zhao, Chang Chen, 2023 Exercise Alleviates ER Reductive Stress and Promotes Healthy Aging, Wang YuanYuan, Qiao XinHua, Shi Chang, Ye AoJun, Guo MiaoMiao, Zhao YuZheng, Chen Chang, 2022 GAPDH S-nitrosation contributes to age-related sarcopenia through mediating apoptosis, Xie, Ting, Qiao, Xinhua, Sun, Chuanxin, Chu, Boyu, Meng, Jiao, Chen, Chang, 2022 A Lycium barbarum extract inhibits beta-amyloid toxicity by activating the antioxidant system and mtUPR in a Caenorhabditis elegans model of Alzheimer's disease, Meng, Jiao, Lv, Zhenyu, Guo, Miaomiao, Sun, Chuanxin, Li, Xiaopeng, Jiang, Zhenguo, Zhang, Wanchang, Chen, Chang, 2022 ER reductive stress caused by Ero1 alpha S-nitrosation accelerates senescence, Qiao, Xinhua, Zhang, Yingmin, Ye, Aojun, Zhang, Yini, Xie, Ting, Lv, Zhenyu, Shi, Chang, Wu, Dongli, Chu, Boyu, Wu, Xun, Zhang, Weiqi, Wang, Ping, Liu, GuangHui, Wang, Chihchen, Wang, Lei, Chen, Chang, 2022 Long noncoding RNA MAGI2-AS3 regulates the H2O2 level and cell senescence via HSPA8, Zhang, Yingmin, Qiao, Xinhua, Liu, Lihui, Han, Wensheng, Liu, Qinghua, Wang, Yuanyuan, Xie, Ting, Tang, Yiheng, Wang, Tiepeng, Meng, Jiao, Ye, Aojun, He, Shunmin, Chen, Runsheng, Chen, Chang, 2022 Nitric oxide inhibits alginate biosynthesis in Pseudomonas aeruginosa and increases its sensitivity to tobramycin by downregulating algU gene expression, Lei Gao, Xinhua Qiao, Lixia Zhang, Yan Wang, Yi Wan, Chang Chen, 2022 精准氧化还原调控, 陈畅, 2022 SLC-30A9 is required for Zn 2+ homeostasis, Zn 2+ mobilization, and mitochondrial health, Huichao Deng, Xinhua Qiao, Ting Xie, Wenfeng Fu, Hang Li, Yanmei Zhao, Miaomiao Guo, Yaqian Feng, Ligong Chen, Yan Zhao, Long Miao, Chang Chen, Kang Shen, Xiangming Wang, 2021 Precision Redox: The Key for Antioxidant Pharmacology, Meng, Jiao, Lv, Zhenyu, Zhang, Yingmin, Wang, Yuanyuan, Qiao, Xinhua, Sun, Chuanxin, Chen, Yuzhe, Guo, Miaomiao, Han, Wensheng, Ye, Aojun, Xie, Ting, Chu, Boyu, Shi, Chang, Yang, Shangpo, Chen, Chang, 2021 Redox-stress response capacity decline and ER reductive stress in aging, Chen, Chang, 2021 Redox environment metabolomic evaluation (REME) of the heart after myocardial ischemia/reperfusion injury, Cai, WenBin, Zhao, YinJiao, Liu, Le, Cheng, Qian, Wang, Jin, Shi, XueLian, Yao, Liu, Qiao, XinHua, Zhu, Yi, Chen, Chang, Zhang, Xu, 2021 GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation, Liu, Qianjin, Gu, Tianle, Su, LingYan, Jiao, Lijin, Qiao, Xinhua, Xie, Ting, Yang, LuXiu, Yu, Dandan, Xu, Ling, Chen, Chang, Yao, YongGang, 2021 Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration, Yi, Weiwei, Zhang, Yuying, Liu, Bo, Zhou, Yuanyuan, Liao, Dandan, Qiao, Xinhua, Gao, Dan, Xie, Ting, Yao, Qin, Zhang, Yao, Qiu, Yugang, Huang, Gang, Chen, Zhiyang, Chen, Chang, Ju, Zhenyu, 2021 Elevated serum 4HNE plus decreased serum thioredoxin: Unique feature and implications for acute exacerbation of chronic obstructive pulmonary disease, Jia Liu, Jin Huang, Hu Liu, Chang Chen, Jianying Xu, Liangwei Zhong, 2021 Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, Zheng, WenQiang, Zhang, Yuying, Yao, Qin, Chen, Yuzhe, Qiao, Xinhua, Wang, EnDuo, Chen, Chang, Zhou, XiaoLong, 2020 An extract of Lycium barbarum mimics exercise to improve muscle endurance through increasing type IIa oxidative muscle fibers by activating ERRγ., Chang Chen, 2020 Phase Separation and Cytotoxicity of Tau are Modulated by Protein Disulfide Isomerase and S-nitrosylation of this Molecular Chaperone, Wang, Kan, Liu, JiaQi, Zhong, Tao, Liu, XiaoLing, Zeng, Yan, Qiao, Xinhua, Xie, Ting, Chen, Yuzhe, Gao, YingYing, Tang, Bo, Li, Jia, Zhou, Jun, Pang, DaiWen, Chen, Jie, Chen, Chang, Liang, Yi, 2020 Preparative Separation of Flavonoids from Goji Berries by Mixed-Mode Macroporous Adsorption Resins and Effect on A beta-Expressing and Anti-Aging Genes, Liu, Jianfei, Meng, Jiao, Du, Jinhao, Liu, Xiaofeng, Pu, Qiaosheng, Di, Duolong, Chen, Chang, 2020 In memoriam Steven Yue Qian (1960-2019), Yin, Huiyong, Buettner, Garry, Chiu, Daniel TsunYee, Zhang, XueJi, Chen, Chang, Mantell, Lin L, 2020 S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal ?-helical lid, Yang, Jie, Zhang, Hong, Gong, Weibin, Liu, Zhenyan, Wu, Huiwen, Hu, Wanhui, Chen, Xinxin, Wang, Lei, Wu, Si, Chen, Chang, Perrett, Sarah, 2020 S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid, Jie Yang, Hong Zhang, Weibin

Areas of Focus

Protein thiol modification
Nitric oxide
Tumor and neurological disease-related targets
Aging and regulation

Publications

Biomarkers of aging, Bao, Hainan, Cao, Jiani, Chen, Mengting, Chen, Min, Chen, Wei, Chen, Xiao, Chen, Yanhao, Chen, Yu, Chen, Yutian, Chen, Zhiyang, Chhetri, Jagadish K, Ding, Yingjie, Feng, Junlin, Guo, Jun, Guo, Mengmeng, He, Chuting, Jia, Yujuan, Jiang, Haiping, Jing, Ying, Li, Dingfeng, Li, Jiaming, Li, Jingyi, Liang, Qinhao, Liang, Rui, Liu, Feng, Liu, Xiaoqian, Liu, Zuojun, Luo, Oscar Junhong, Lv, Jianwei, Ma, Jingyi, Mao, Kehang, Nie, Jiawei, Qiao, Xinhua, Sun, Xinpei, Tang, Xiaoqiang, Wang, Jianfang, Wang, Qiaoran, Wang, Siyuan, Wang, Xuan, Wang, Yaning, Wang, Yuhan, Wu, Rimo, Xia, Kai, Xiao, FuHui, Xu, Lingyan, Xu, Yingying, Yan, Haoteng, Yang, Liang, Yang, Ruici, Yang, Yuanxin, Ying, Yilin, Zhang, Le, Zhang, Weiwei, Zhang, Wenwan, Zhang, Xing, Zhang, Zhuo, Zhou, Min, Zhou, Rui, Zhu, Qingchen, Zhu, Zhengmao, Cao, Feng, Cao, Zhongwei, Chan, Piu, Chen, Chang, Chen, Guobing, Chen, HouZao, Chen, Jun, Ci, Weimin, Ding, BiSen, Ding, Qiurong, Gao, Feng, Han, JingDong J, Huang, Kai, Ju, Zhenyu, Kong, Qing, 2023
Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, Miaomiao Guo, Xinhua Qiao, Yuanyuan Wang, ZiHan Li, Chang Shi, Yun Chen, Lu Kang, Chang Chen, XiaoLong Zhou, 2023
Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis, Chang Chen, 2023
LBP1C-2 from Lycium barbarum maintains skeletal muscle satellite cell pool by interaction with FGFR1, Jiao Meng, Zhenyu Lv, Xia Chen, Chuanxin Sun, Can Jin, Kan Ding, Chang Chen, 2023
Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells, Jiao Meng, Yuanyuan Wang, Zhenyu Lv, Xinhua Qiao, Qiaoli Zhu, Chang Chen, 2023
Multi-Omics Approach Reveals Redox Homeostasis Reprogramming in Early-Stage Clear Cell Renal Cell Carcinoma, Zhang, Wei, Qiao, Xinhua, Xie, Ting, Cai, Wenbin, Zhang, Xu, Chen, Chang, Zhang, Yaoguang, 2023
LBP1C-2 from Lycium barbarum alleviated age-related bone loss by targeting BMPRIA/BMPRII/Noggin, Sun, Chuanxin, Chen, Xia, Yang, Shangpo, Jin, Can, Ding, Kan, Chen, Chang, 2023
Exploring the precision redox map during fasting-refeeding and satiation in C. elegans, Xinhua Qiao, Lu Kang, Chang Shi, Aojun Ye, Dongli Wu, Yuyunfei Huang, Minghao Deng, Jiarui Wang, Yuzheng Zhao, Chang Chen, 2023
Exercise Alleviates ER Reductive Stress and Promotes Healthy Aging, Wang YuanYuan, Qiao XinHua, Shi Chang, Ye AoJun, Guo MiaoMiao, Zhao YuZheng, Chen Chang, 2022
GAPDH S-nitrosation contributes to age-related sarcopenia through mediating apoptosis, Xie, Ting, Qiao, Xinhua, Sun, Chuanxin, Chu, Boyu, Meng, Jiao, Chen, Chang, 2022
A Lycium barbarum extract inhibits beta-amyloid toxicity by activating the antioxidant system and mtUPR in a Caenorhabditis elegans model of Alzheimer's disease, Meng, Jiao, Lv, Zhenyu, Guo, Miaomiao, Sun, Chuanxin, Li, Xiaopeng, Jiang, Zhenguo, Zhang, Wanchang, Chen, Chang, 2022
ER reductive stress caused by Ero1 alpha S-nitrosation accelerates senescence, Qiao, Xinhua, Zhang, Yingmin, Ye, Aojun, Zhang, Yini, Xie, Ting, Lv, Zhenyu, Shi, Chang, Wu, Dongli, Chu, Boyu, Wu, Xun, Zhang, Weiqi, Wang, Ping, Liu, GuangHui, Wang, Chihchen, Wang, Lei, Chen, Chang, 2022
Long noncoding RNA MAGI2-AS3 regulates the H2O2 level and cell senescence via HSPA8, Zhang, Yingmin, Qiao, Xinhua, Liu, Lihui, Han, Wensheng, Liu, Qinghua, Wang, Yuanyuan, Xie, Ting, Tang, Yiheng, Wang, Tiepeng, Meng, Jiao, Ye, Aojun, He, Shunmin, Chen, Runsheng, Chen, Chang, 2022
Nitric oxide inhibits alginate biosynthesis in Pseudomonas aeruginosa and increases its sensitivity to tobramycin by downregulating algU gene expression, Lei Gao, Xinhua Qiao, Lixia Zhang, Yan Wang, Yi Wan, Chang Chen, 2022
精准氧化还原调控, 陈畅, 2022
SLC-30A9 is required for Zn 2+ homeostasis, Zn 2+ mobilization, and mitochondrial health, Huichao Deng, Xinhua Qiao, Ting Xie, Wenfeng Fu, Hang Li, Yanmei Zhao, Miaomiao Guo, Yaqian Feng, Ligong Chen, Yan Zhao, Long Miao, Chang Chen, Kang Shen, Xiangming Wang, 2021
Precision Redox: The Key for Antioxidant Pharmacology, Meng, Jiao, Lv, Zhenyu, Zhang, Yingmin, Wang, Yuanyuan, Qiao, Xinhua, Sun, Chuanxin, Chen, Yuzhe, Guo, Miaomiao, Han, Wensheng, Ye, Aojun, Xie, Ting, Chu, Boyu, Shi, Chang, Yang, Shangpo, Chen, Chang, 2021
Redox-stress response capacity decline and ER reductive stress in aging, Chen, Chang, 2021
Redox environment metabolomic evaluation (REME) of the heart after myocardial ischemia/reperfusion injury, Cai, WenBin, Zhao, YinJiao, Liu, Le, Cheng, Qian, Wang, Jin, Shi, XueLian, Yao, Liu, Qiao, XinHua, Zhu, Yi, Chen, Chang, Zhang, Xu, 2021
GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation, Liu, Qianjin, Gu, Tianle, Su, LingYan, Jiao, Lijin, Qiao, Xinhua, Xie, Ting, Yang, LuXiu, Yu, Dandan, Xu, Ling, Chen, Chang, Yao, YongGang, 2021
Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration, Yi, Weiwei, Zhang, Yuying, Liu, Bo, Zhou, Yuanyuan, Liao, Dandan, Qiao, Xinhua, Gao, Dan, Xie, Ting, Yao, Qin, Zhang, Yao, Qiu, Yugang, Huang, Gang, Chen, Zhiyang, Chen, Chang, Ju, Zhenyu, 2021
Elevated serum 4HNE plus decreased serum thioredoxin: Unique feature and implications for acute exacerbation of chronic obstructive pulmonary disease, Jia Liu, Jin Huang, Hu Liu, Chang Chen, Jianying Xu, Liangwei Zhong, 2021
Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, Zheng, WenQiang, Zhang, Yuying, Yao, Qin, Chen, Yuzhe, Qiao, Xinhua, Wang, EnDuo, Chen, Chang, Zhou, XiaoLong, 2020
An extract of Lycium barbarum mimics exercise to improve muscle endurance through increasing type IIa oxidative muscle fibers by activating ERRγ., Chang Chen, 2020
Phase Separation and Cytotoxicity of Tau are Modulated by Protein Disulfide Isomerase and S-nitrosylation of this Molecular Chaperone, Wang, Kan, Liu, JiaQi, Zhong, Tao, Liu, XiaoLing, Zeng, Yan, Qiao, Xinhua, Xie, Ting, Chen, Yuzhe, Gao, YingYing, Tang, Bo, Li, Jia, Zhou, Jun, Pang, DaiWen, Chen, Jie, Chen, Chang, Liang, Yi, 2020
Preparative Separation of Flavonoids from Goji Berries by Mixed-Mode Macroporous Adsorption Resins and Effect on A beta-Expressing and Anti-Aging Genes, Liu, Jianfei, Meng, Jiao, Du, Jinhao, Liu, Xiaofeng, Pu, Qiaosheng, Di, Duolong, Chen, Chang, 2020
In memoriam Steven Yue Qian (1960-2019), Yin, Huiyong, Buettner, Garry, Chiu, Daniel TsunYee, Zhang, XueJi, Chen, Chang, Mantell, Lin L, 2020
S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal ?-helical lid, Yang, Jie, Zhang, Hong, Gong, Weibin, Liu, Zhenyan, Wu, Huiwen, Hu, Wanhui, Chen, Xinxin, Wang, Lei, Wu, Si, Chen, Chang, Perrett, Sarah, 2020
S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid, Jie Yang, Hong Zhang, Weibin

Protein Thiol Modification Nitric Oxide Tumor Neurological Disease Targets Aging Regulation

Han Song Deng - Tongji University

Fanglin Sun - Tongji University

Shi Jiejun - Tongji University

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