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Hongyu Deng
Life Science
University of Chinese Academy of Sciences
Beijing
Language: English, Chinese
Virus
Replication
Assembly
Release
Molecular Mechanism
Innate Immune System
Interaction
Novel Vaccines
Herpesvirus
Coronavirus
Areas of Focus
- Molecular Mechanisms of Virus Replication and Assembly Release
- Interaction between Viruses and Host Innate Immune System
- Development of Novel Vaccines
Work Experience
- 2004-11~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
- 2004-07~2004-11 - University of California, Los Angeles - Assistant Professor
- 2002-07~2004-06 - University of California, Los Angeles - Assistant Researcher
- 1998-01~2002-06 - Albert Einstein College of Medicine and University of California, Los Angeles - Postdoctoral Researcher
Academic Background & Achievements
- 1992-01--1997-12 PhD: University of Rochester
- 1987-09--1991-07 Bachelor's Degree: Zhejiang University
Publications
- HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomography, 7th Author, 2023
- Liquid-liquid phase separation mediates the formation of herpesvirus assembly compartments, Corresponding Author, 2023
- RNF213 modulates γ-herpesvirus infection and reactivation via targeting the viral Replication and Transcription Activator, Corresponding Author, 2023
- Genome-Wide CRISPR-Cas9 Screen Identifies SMCHD1 as a Restriction Factor for Herpesviruses, 13th Author, 2023
- Induction of membraneless organelles as a strategy for HIV-1 post-nuclear entry steps, Corresponding Author, 2023
- DMV biogenesis during beta-coronavirus infection requires autophagy proteins VMP1 and TMEM41B, Corresponding Author, 2022
- VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection, Corresponding Author, 2022
- Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport, Corresponding Author, 2022
- The Interaction between Tegument Proteins ORF33 and ORF45 Plays an Essential Role in Cytoplasmic Virion Maturation of a Gammaherpesvirus, Corresponding Author, 2022
- Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion, Corresponding Author, 2021
- A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates, Corresponding Author, 2021
- Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10, Corresponding Author, 2020
- PPM1G restricts innate immune signaling mediated by STING and MAVS and is hijacked by KSHV for immune evasion, Corresponding Author, 2020
- Functional Identification and Characterization of the Nuclear Egress Complex of a Gammaherpesvirus, Corresponding Author, 2019
- Remodeling of host membranes during herpesvirus assembly and egress, Corresponding Author, 2019
- Virus-Like Vesicles of Kaposi's Sarcoma-Associated Herpesvirus Activate Lytic Replication by Triggering Differentiation Signaling, 9th Author, 2017
- Tegument Protein ORF45 Plays an Essential Role in Virion Morphogenesis of Murine Gammaherpesvirus 68, Corresponding Author, 2016
- The hepatitis C virus protein NS3 suppresses TNF-alpha-stimulated activation of NF-kappa B by targeting LUBAC, Corresponding Author, 2015
- Murine Gammaherpesvirus 68 ORF48 Is an RTA-Responsive Gene Product and Functions in both Viral Lytic Replication and Latency during In Vivo Infection, Corresponding Author, 2015
- Gammaherpesvirus Tegument Protein ORF33 Is Associated with Intranuclear Capsids at an Early Stage of the Tegumentation Process, Corresponding Author, 2015
- Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hepatitis C Virus Replication via Distinct Mechanisms, Corresponding Author, 2014
- Murine gammaherpesvirus-68 ORF38 encodes a tegument protein and is packaged into virions during secondary envelopment, Corresponding Author, 2014
- ZAP Inhibits Murine Gammaherpesvirus 68 ORF64 Expression and Is Antagonized by RTA, Corresponding Author, 2013
- Zinc Finger Antiviral Protein Inhibits Murine Gammaherpesvirus 68 M2 Expression and Regulates Viral Latency in Cultured Cells, Corresponding Author, 2012
- Distinct Domains in ORF52 Tegument Protein Mediate Essential Functions in Murine Gammaherpesvirus 68 Virion Tegumentation and Secondary Envelopment, Corresponding Author, 2012
- CCAAT/enhancer binding proteins play a role in oriLyt-dependent genome replication during MHV-68 de novo infection, Corresponding Author, 2011
- An Integrated Approach to Elucidate the Intra-Viral and Viral-Cellular Protein Interaction Networks of a Gamma-Herpesvirus, Collaborating Author, 2011
- TNF Receptor 1 Mediates Dendritic Cell Maturation and CD8 T Cell Response through Two Distinct Mechanisms, Corresponding Author, 2011
- Identification of an RTA Responsive Element in Murine Gammaherpesvirus-68 Genome, Corresponding Author, 2011
- Replication and Transcription Activator (RTA) of Murine Gammaherpesvirus 68 Binds to an RTA-Responsive Element and Activates the Expression of ORF18, Corresponding Author, 2011
- Interferon-gamma negatively regulates Th17-mediated immunopathology during mouse hepatitis virus infection, Corresponding Author, 2011
- Role of tegument proteins in herpesvirus assembly and egress, Corresponding Author, 2010
- Identification and functional characterization of the left origin of lytic replication of murine gammaherpesvirus 68, Corresponding Author, 2009
- mRNA Display Design of Fibronectin-based Intrabodies That Detect and Inhibit Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein, 4th Author, 2009
- RTA Promoter Demethylation and Histone Acetylation Regulation of Murine Gammaherpesvirus 68 Reactivation, Corresponding Author, 2009
- Open Reading Frame 33 of a Gammaherpesvirus Encodes a Tegument Protein Essential for Virion Morphogenesis and Egress, Corresponding Author, 2009
- Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways, Corresponding Author, 2008
- Structural and Functional Studies of the Abundant Tegument Protein ORF52 from Murine Gammaherpesvirus 68, 10th Author, 2007
- Murine Gammaherpesvirus 68 ORF52 Encodes a Tegument Protein Required for Virion Morphogenesis in the Cytoplasm, 6th Author, 2007
- Regulation of KSHV lytic gene expression, Not mentioned, 2007
- Identification of cis-sequences required for lytic DNA replication and packaging of murine gammaherpesvirus 68, 1st Author, 2004
- Effective inhibition of Rta expression and lytic replication of Kaposi's sarcoma-associated herpesvirus by human RNase P, Not mentioned, 2004
- Transcriptional Regulation of the Interleukin-6 Gene of Human Herpesvirus 8 (Kaposi's Sarcoma-Associated Herpesvirus), Not mentioned, 2002
- Human Immunodeficiency Virus Type-1 Activates Lytic Cycle Replication of Kaposi's Sarcoma-Associated Herpesvirus through Induction of KSHV Rta, Not mentioned, 2002
- Rta of the human herpesvirus 8/Kaposi’s sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression, 1st Author, 2002
- Auto-activation of the rta gene of human herpesvirus 8/Kaposi’s sarcoma-associated herpesvirus, 1st Author, 2000
- Functional Identification and Analysis of cis-Acting Sequences Which Mediate Genome Cleavage and Packaging in Human Herpesvirus 6, Not mentioned, 1998
Awards
- National 'Ten Thousand Talents Program' Leading Talent (2018)
- Young and Middle-aged Leading Talent in Scientific and Technological Innovation (2016)
- National Outstanding Youth Science Fund (2013)
- Chinese Academy of Sciences Award (2005)
