1987-09--1991-07 Bachelor's Degree: Zhejiang University
2004-11~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
2004-07~2004-11 - University of California, Los Angeles - Assistant Professor
2002-07~2004-06 - University of California, Los Angeles - Assistant Researcher
1998-01~2002-06 - Albert Einstein College of Medicine and University of California, Los Angeles - Postdoctoral Researcher
National 'Ten Thousand Talents Program' Leading Talent (2018)
Young and Middle-aged Leading Talent in Scientific and Technological Innovation (2016)
National Outstanding Youth Science Fund (2013)
Chinese Academy of Sciences Award (2005)
Research
Molecular Mechanisms of Virus Replication and Assembly Release Interaction between Viruses and Host Innate Immune System Development of Novel Vaccines
HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomography, 7th Author, 2023
Liquid-liquid phase separation mediates the formation of herpesvirus assembly compartments, Corresponding Author, 2023
RNF213 modulates γ-herpesvirus infection and reactivation via targeting the viral Replication and Transcription Activator, Corresponding Author, 2023
Genome-Wide CRISPR-Cas9 Screen Identifies SMCHD1 as a Restriction Factor for Herpesviruses, 13th Author, 2023
Induction of membraneless organelles as a strategy for HIV-1 post-nuclear entry steps, Corresponding Author, 2023
DMV biogenesis during beta-coronavirus infection requires autophagy proteins VMP1 and TMEM41B, Corresponding Author, 2022
VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection, Corresponding Author, 2022
Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport, Corresponding Author, 2022
The Interaction between Tegument Proteins ORF33 and ORF45 Plays an Essential Role in Cytoplasmic Virion Maturation of a Gammaherpesvirus, Corresponding Author, 2022
A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates, Corresponding Author, 2021
Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10, Corresponding Author, 2020
PPM1G restricts innate immune signaling mediated by STING and MAVS and is hijacked by KSHV for immune evasion, Corresponding Author, 2020
Functional Identification and Characterization of the Nuclear Egress Complex of a Gammaherpesvirus, Corresponding Author, 2019
Remodeling of host membranes during herpesvirus assembly and egress, Corresponding Author, 2019
Virus-Like Vesicles of Kaposi's Sarcoma-Associated Herpesvirus Activate Lytic Replication by Triggering Differentiation Signaling, 9th Author, 2017
Tegument Protein ORF45 Plays an Essential Role in Virion Morphogenesis of Murine Gammaherpesvirus 68, Corresponding Author, 2016
The hepatitis C virus protein NS3 suppresses TNF-alpha-stimulated activation of NF-kappa B by targeting LUBAC, Corresponding Author, 2015
Murine Gammaherpesvirus 68 ORF48 Is an RTA-Responsive Gene Product and Functions in both Viral Lytic Replication and Latency during In Vivo Infection, Corresponding Author, 2015
Gammaherpesvirus Tegument Protein ORF33 Is Associated with Intranuclear Capsids at an Early Stage of the Tegumentation Process, Corresponding Author, 2015
Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hepatitis C Virus Replication via Distinct Mechanisms, Corresponding Author, 2014
Murine gammaherpesvirus-68 ORF38 encodes a tegument protein and is packaged into virions during secondary envelopment, Corresponding Author, 2014
ZAP Inhibits Murine Gammaherpesvirus 68 ORF64 Expression and Is Antagonized by RTA, Corresponding Author, 2013
Zinc Finger Antiviral Protein Inhibits Murine Gammaherpesvirus 68 M2 Expression and Regulates Viral Latency in Cultured Cells, Corresponding Author, 2012
Distinct Domains in ORF52 Tegument Protein Mediate Essential Functions in Murine Gammaherpesvirus 68 Virion Tegumentation and Secondary Envelopment, Corresponding Author, 2012
CCAAT/enhancer binding proteins play a role in oriLyt-dependent genome replication during MHV-68 de novo infection, Corresponding Author, 2011
An Integrated Approach to Elucidate the Intra-Viral and Viral-Cellular Protein Interaction Networks of a Gamma-Herpesvirus, Collaborating Author, 2011
TNF Receptor 1 Mediates Dendritic Cell Maturation and CD8 T Cell Response through Two Distinct Mechanisms, Corresponding Author, 2011
Identification of an RTA Responsive Element in Murine Gammaherpesvirus-68 Genome, Corresponding Author, 2011
Replication and Transcription Activator (RTA) of Murine Gammaherpesvirus 68 Binds to an RTA-Responsive Element and Activates the Expression of ORF18, Corresponding Author, 2011
Role of tegument proteins in herpesvirus assembly and egress, Corresponding Author, 2010
Identification and functional characterization of the left origin of lytic replication of murine gammaherpesvirus 68, Corresponding Author, 2009
mRNA Display Design of Fibronectin-based Intrabodies That Detect and Inhibit Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein, 4th Author, 2009
RTA Promoter Demethylation and Histone Acetylation Regulation of Murine Gammaherpesvirus 68 Reactivation, Corresponding Author, 2009
Open Reading Frame 33 of a Gammaherpesvirus Encodes a Tegument Protein Essential for Virion Morphogenesis and Egress, Corresponding Author, 2009
Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways, Corresponding Author, 2008
Structural and Functional Studies of the Abundant Tegument Protein ORF52 from Murine Gammaherpesvirus 68, 10th Author, 2007
Murine Gammaherpesvirus 68 ORF52 Encodes a Tegument Protein Required for Virion Morphogenesis in the Cytoplasm, 6th Author, 2007
Regulation of KSHV lytic gene expression, Not mentioned, 2007
Identification of cis-sequences required for lytic DNA replication and packaging of murine gammaherpesvirus 68, 1st Author, 2004
Effective inhibition of Rta expression and lytic replication of Kaposi's sarcoma-associated herpesvirus by human RNase P, Not mentioned, 2004
Transcriptional Regulation of the Interleukin-6 Gene of Human Herpesvirus 8 (Kaposi's Sarcoma-Associated Herpesvirus), Not mentioned, 2002
Human Immunodeficiency Virus Type-1 Activates Lytic Cycle Replication of Kaposi's Sarcoma-Associated Herpesvirus through Induction of KSHV Rta, Not mentioned, 2002
Rta of the human herpesvirus 8/Kaposi’s sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression, 1st Author, 2002
Auto-activation of the rta gene of human herpesvirus 8/Kaposi’s sarcoma-associated herpesvirus, 1st Author, 2000
Functional Identification and Analysis of cis-Acting Sequences Which Mediate Genome Cleavage and Packaging in Human Herpesvirus 6, Not mentioned, 1998
