1999 - B.S. in Biochemical Engineering: Fuzhou University
2005 - M.S. in Cell Biology: Xiamen University
2008 - Ph.D. in Biochemistry and Molecular Biology: Xiamen University
2009 to Present - Xiamen University, School of Life Sciences - Assistant Professor/Associate Professor/Professor
2021: National Natural Science Foundation Major Research Plan Cultivation Project
2021: Fujian Provincial Science and Technology Major Project
2021: National Natural Science Foundation General Project
2021: Fujian Provincial Natural Science Foundation Key Project
2020: National Key R&D Program Project
2019: National Natural Science Foundation General Project
2017: National Natural Science Foundation General Project
2014: National Natural Science Foundation General Project
2010: National Natural Science Foundation Youth Project
2020: National Advanced Collective Award for Fighting COVID-19
2018: Fujian Provincial Science and Technology Progress Second Prize
2018: Xiamen Science and Technology Progress Second Prize
2015: Qiushi Outstanding Scientific Achievement Collective Award
2015: Fujian Provincial Science and Technology Progress First Prize
2014: Xiamen Science and Technology Progress Second Prize
2014: Xiamen Science and Technology Progress Third Prize
2003: Beijing Science and Technology Progress Third Prize
Research
Infectious Diseases Research Cancer Research
A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2., Chen J, Wang P, Yuan L, Zhang L, Zhang L, Zhao H, Chen C, Wang X, Han J, Chen Y, Jia J, Lu Z, Hong J, Lu Z, Wang Q, Chen R, Qi R, Ma J, Zhou M, Yu H, Zhuang C, Liu X, Han Q, Wang G, Su Y, Yuan Q, Cheng T, Wu T*, Ye X*, Zhang T*, Li C*, Zhang J*, Zhu H*, Chen Y*, Chen H*, Xia N*., 2022
Safety and immunogenicity of a live-attenuated influenza virus vector-based intranasal SARS-CoV-2 vaccine in adults: randomised, double-blind, placebo-controlled, phase 1 and 2 trials., Zhu F*, Zhuang C, Chu K, Zhang L, Zhao H, Huang S, Su Y, Lin H, Yang C, Jiang H, Zang X, Liu D, Pan H, Hu Y, Liu X, Chen Q, Song Q, Quan J, Huang Z, Zhong G, Chen J, Han J, Sun H, Cui L, Li J, Chen Y*, Zhang T*, Ye X*, Li C*, Wu T*, Zhang J*, Xia NS*., 2022
Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses., Li T, Chen J, Zheng Q, Xue W, Zhang L, Rong R, Zhang S, Wang Q, Hong M, Zhang Y, Cui L, He M, Lu Z, Zhang Z, Chi X, Li J, Huang Y, Wang H, Tang J, Ying D, Zhou L, Wang Y, Yu H, Zhang J, Gu Y, Chen Y*, Li S*, Xia N*., 2022
Structures of pseudorabies virus capsids., Wang G, Zha Z, Huang P, Sun H, Huang Y, He M, Chen T, Lin L, Chen Z, Kong Z, Que Y, Li T, Gu Y, Yu H, Zhang J, Zheng Q, Chen Y*, Li S*, Xia N*., 2022
Protective anti-gB neutralizing antibodies targeting two vulnerable sites for EBV-cell membrane fusion., Zhang X*, Hong J, Zhong L, Wu Q, Zhang S, Zhu Q, Chen H, Wei D, Li R, Zhang W, Zhang X, Wang G, Zhou X, Chen J, Kang Y, Zha Z, Duan X, Huang Y, Sun C, Kong X, Zhou Y, Chen Y, Ye X, Feng Q, Li S, Xiang T, Gao S, Zeng MS, Zheng Q*, Chen Y*, Zeng YX*, Xia N*, Xu M*., 2022
Glycoprotein B Antibodies Completely Neutralize EBV Infection of B Cells., Hong J, Wei D, Zhong L, Wu Q, Chen K, Zhang W, Yang Y, Chen J, Xia N, Zhang X*, Chen Y*., 2022
A Neutralizing Antibody Targeting gH Provides Potent Protection against EBV Challenge In Vivo., Hong J, Zhong L, Zheng Q, Wu Q, Zha Z, Wei D, Chen H, Zhang W, Zhang S, Huang Y, Chen K, Chen J, Li S, Zeng MS, Zeng YX, Xia N, Zhang X*, Xu M*, Chen Y*., 2022
A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity., Wang X*, Yin X, Zhang B, Liu C, Lin Y, Huang X, Li Y, Shen C, Zheng W, Fu G, Chen J, Wen Y, Zhang W, Pan BS, Fang M, Zheng Z, Zhang Z, Yuan Q, Fu G, Li S, Zhang J, Chen Y*, Xia N*, Zhao Q*., 2022
Vaccination with Deglycosylated Modified Hemagglutinin Broadly Protects against Influenza Virus Infection in Mice and Ferrets., Zhang L, Chen J, Shen C, Wang G, Lu Z, Zeng D, Gao Y, Chen H, Xia N, Chen Y*., 2022
A Hemagglutinin Stem Vaccine Designed Rationally by AlphaFold2 Confers Broad Protection against Influenza B Infection., Zeng D, Xin J, Yang K, Guo S, Wang Q, Gao Y, Chen H, Ge J, Lu Z, Zhang L, Chen J, Chen Y*, Xia N., 2022
Development of functional antibodies against influenza B virus by activation-induced cytidine deaminase in hybridoma cells., Chen Y, Shen C*, Chen J, Chen J, Chen F, Zhang L, Liu X, Chen S, Xue S, Liu Y, Tang J, Yuan Q, Chen Y*, Luo W*, Xia N., 2022
Adefovir dipivoxil efficiently inhibits the proliferation of pseudorabies virus in vitro and in vivo., Wang G, Chen R, Huang P, Hong J, Cao J, Wu Q, Zheng W, Lin L, Han Q, Chen Y*, Xia N., 2021
Antibody Generation and Immunogenicity Analysis of EBV gp42 N-Terminal Region., Hong J, Wei D, Wu Q, Zhong L, Chen K, Huang Y, Zhang W, Chen J, Xia N, Zhang X, Chen Y*., 2021
Establishment of a rapid ELISPOT assay for influenza virus titration and neutralizing antibody detection., Wang G, Huang P, Hong J, Fu R, Wu Q, Chen R, Lin L, Han Q, Chen H, Chen Y*, Xia N., 2021
Rabbit Monoclonal Antibody Specifically Recognizing a Linear Epitope in the RBD of SARS-CoV-2 Spike Protein., Hong J, Wang Q, Wu Q, Chen J, Wang X, Wang Y, Chen Y*, Xia N., 2021
An IgM antibody targeting the receptor binding site of influenza B blocks viral infection with great breadth and potency., Shen C, Zhang M, Chen Y, Zhang L, Wang G, Chen J, Chen S, Li Z, Wei F, Chen J, Yang K, Guo S, Wang Y, Zheng Q, Yu H, Luo W, Zhang J, Chen H, Chen Y*, Xia N., 2019
Nanobody-based sandwich reporter system for living cell sensing influenza A virus infection., Cao J, Zhong N, Wang G, Wang M, Zhang B, Fu B, Wang Y, Zhang T, Zhang Y, Yang K, Chen Y*, Yuan Q*, Xia N., 2019
Rapid identification of imported influenza viruses at Xiamen International Airport via an active surveillance program., Chen J, Yang K, Zhang M*, Shen C, Chen J, Wang G, Huang S, Zhang M, Xiong H, Chen H, Chen Y*, Xia N., 2018
Rapid detection of MERS coronavirus-like viruses in bats: potential for tracking MERS coronavirus transmission and animal origin., Woo PCY #, Lau SKP #, Chen Y#, Wong EYM, Chan KH, Chen H, Zhang L, Xia N, Yuen KY., 2018
Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus., Lin Q #, Li T #, Chen Y #, Lau SY, Wei M, Zhang Y, Zhang Z, Yao Q, Li J, Li Z, Wang D, Zheng Q, Yu H, Gu Y, Zhang J, Chen H, Li S, Xia N., 2018
A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses., Shen C, Chen J, Li R, Zhang M, Wang G, Stegalkina S, Zhang L, Chen J, Cao J, Bi X, Anderson SF, Alefantis T, Zhang M, Cai X, Yang K, Zheng Q, Fang M, Yu H, Luo W, Zheng Z, Yuan Q, Zhang J, Wai-Kuo Shih J, Kleanthous H, Chen H, Chen Y*, Xia N*., 2017
A highly specific rapid antigen detection assay for on-site diagnosis of MERS., Chen Y, Chan KH, Hong C, Kang Y, Ge S, Chen H, Wong EY, Joseph S, Patteril NG, Wernery U, Xia N, Lau SK, Woo PC., 2016
Virus-mimetic nanovesicles as a versatile antigen-delivery system., Zhang P #, Chen Y #, Zeng Y #, Shen C, Li R, Guo Z, Li S, Zheng Q, Chu C, Wang Z, Zheng Z, Tian R, Ge S, Zhang X, Xia NS, Liu G, Chen X., 2015
A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus., Chen Y, Chan KH, Kang Y, Chen H, Luk HK, Poon RW, Chan JF, Yuen KY, Xia N, Lau SK, Woo PC., 2015
An important amino acid in nucleoprotein contributes to influenza A virus replication by interacting with polymerase PB2., Gui X, Li R, Zhang X, Shen C, Yu H, Guo X, Kang Y, Chen J, Chen H, Chen Y*, Xia N*., 2014
Identification of a highly conserved and surface exposed B-cell epitope on the nucleoprotein of influenza A virus., Gui X, Ge P, Wang X, Yang K, Yu H, Zhao Q, Chen Y*, Xia N*., 2014
Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: Current genotyping of EV71 does not reflect their antigenicity., Chen Y #, Li C #, He D, Cheng T, Ge S, Shih JW, Zhao Q, Chen P-J, Zhang J, Xia N., 2013
The 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: Implications for the prevalence of oseltamivir resistant variant viruses., Wu WL, Lau SY, Chen Y, Wang G, Mok BW, Wen X, Wang P, Song W, Lin T, Chan KH, Yuen KY, Chen H., 2012
Serological survey of antibodies to influenza A viruses on a group of people without a history of influenza vaccination., Chen Y #, Zheng Q #, Yang K, Zen F, Lau S-Y, Wu WL, Huang S, Zhang J, Chen H, Xia N., 2011
Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses., Zheng Q, Xia L, Wu WL, Zheng Z, Huo Y, Wu J, Liu Y, Yu H, Chen Y, Lau SY, Chen H, Luo W, Xia N., 2011
A rapid test for the detection of influenza A virus including pandemic influenza A/H1N1 2009., Chen Y, Xu F, Gui X, Yang K, Wu X, Zheng Q, Ge S, Yuan Q, Yeo AET, Zhang J, Guan Y, Chen H, Xia N., 2009
Broad Cross-Protection against H5N1 Avian Influenza Virus Infection by Means of Monoclonal Antibodies that Map to Conserved Viral Epitopes., Chen Y #, Qin K #, Wu WL, Li G, Zhang J, Du H, Ng MH, Shih JWK, Peiris JSM, Guan Y, Chen H, and Xia N., 2009
Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007., WL Wu #, Chen Y #, Wang P, Song W, Lau SY, Rayner JM, Smith GJD, Webster RG, Peiris JSM, Lin T, Xia N, Guan Y and Chen H., 2008
Evaluation of a rapid test for detection of H5N1 avian influenza virus., Chen Y, F Xu, X Fan, H Luo, S Ge, Q Zheng, N Xia, H Chen, Y Guan, and J Zhang., 2008
Area of Focus
Anti-Tumor | Extracellular Vesicles | Delivery Systems | Biomedical Engineering | Nanomedicine | Cancer Therapy | Drug Delivery | Cell Communication | Molecular Biology | Therapeutic Agents
