Professor | Zusen Fan | Asia Growth Partners

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Name	Zusen Fan
Language ability	Chinese, English
Province	Beijing

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Name

Zusen Fan

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1998 - PhD in Immunology: Shanghai Jiao Tong University School of Medicine 2003 - Lecturer: Harvard Medical School 2004 - Researcher: Institute of Biophysics, Chinese Academy of Sciences 2005 - Recipient: Distinguished Young Scholar Fund 2006 - Selected: National New Century Talent Project 2010 - Expert: State Council Special Allowance 2014 - Recipient: Tan Jiazhen Life Science Innovation Award 2016, 2018 - Excellent Graduate Advisor: Chinese Academy of Sciences 2018 - Recipient: Beijing Science and Technology Progress Award (First Prize) 2019 - Chief Scientist: National Natural Science Foundation Innovation Group 2020 - Chief Scientist: National Key R&D Program
Work Experience	2003 - 2004 - Harvard Medical School - Lecturer 2004 - Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
Awards	2009: Beijing Natural Science Award (Third Prize) 2014: Tan Jiazhen Life Science Innovation Award 2018: Beijing Science and Technology Progress Award (First Prize)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1998 - PhD in Immunology: Shanghai Jiao Tong University School of Medicine
2003 - Lecturer: Harvard Medical School
2004 - Researcher: Institute of Biophysics, Chinese Academy of Sciences
2005 - Recipient: Distinguished Young Scholar Fund
2006 - Selected: National New Century Talent Project
2010 - Expert: State Council Special Allowance
2014 - Recipient: Tan Jiazhen Life Science Innovation Award
2016, 2018 - Excellent Graduate Advisor: Chinese Academy of Sciences
2018 - Recipient: Beijing Science and Technology Progress Award (First Prize)
2019 - Chief Scientist: National Natural Science Foundation Innovation Group
2020 - Chief Scientist: National Key R&D Program

Work Experience

2003 - 2004 - Harvard Medical School - Lecturer
2004 - Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher

Awards

2009: Beijing Natural Science Award (Third Prize)
2014: Tan Jiazhen Life Science Innovation Award
2018: Beijing Science and Technology Progress Award (First Prize)

Areas of Focus	Discovery of new subsets in innate immunity and mechanisms against infection/tumor Non-coding RNA and immune regulation Tumor stem cells and tumor immunity
Publications	Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability, Guo, Hui, Zhang, Jiahang, Jiang, Zhimin, Zhu, Xiaoxiao, Yang, Jing, Mu, Rui, Du, Ying, Tian, Yong, Zhu, Pingping, Fan, Zusen, 2023 FOXO1 orchestrates the intestinal homeostasis via neuronal signaling in group 3 innate lymphoid cells, Shao, Fei, Liu, Zhen, Wei, Qinglin, Yu, Dou, Zhao, Min, Zhang, Xusheng, Gao, Xintong, Fan, Zusen, Wang, Shuo, 2023 Noncoding RNAs in tumorigenesis and tumor therapy, Pingping Zhu, Benyu Liu, Zusen Fan, 2023 Regulation of noncoding RNAs in innate lymphoid cells, Liu, Benyu, Zhang, Lingwei, Zhu, Pingping, Fan, Zusen, 2023 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal, pingping zhu, 范祖森, 2022 Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine, Xiong, Zhen, Zhu, Xiaoxiao, Geng, Jingjing, Xu, Yuwei, Wu, Runyuan, Li, Cunzhen, Fan, Dongdong, Qin, Xiwen, Du, Ying, Tian, Yong, Fan, Zusen, 2022 circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription, 范祖森, Nian Liu, 2022 Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity, Ye, Buqing, Yang, Liuliu, Liu, Benyu, Liu, Nian, Fan, Dongdong, Li, Huimu, Sun, Lei, Du, Ying, Wang, Shuo, Tian, Yong, Fan, Zusen, 2022 Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons, Zhu, Pingping, Lu, Tiankun, Wu, Jiayi, Fan, Dongdong, Liu, Benyu, Zhu, Xiaoxiao, Guo, Hui, Du, Ying, Liu, Feng, Tian, Yong, Fan, Zusen, 2022 Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF, Chen, Zhenzhen, Lu, Tiankun, Huang, Lan, Wang, Zhiwei, Yan, Zhongyi, Guan, Yubo, Hu, Wenjing, Fan, Zusen, Zhu, Pingping, 2021 Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m(6)A demethylation of Nr4a1 mRNA, Benyu Liu, Nian Liu, Xiaoxiao Zhu, Liuliu Yang, Buqing Ye, Huimu Li, Pingping Zhu, Tiankun Lu, Yong Tian, Zusen Fan, 2021 N1-methyladenosinemethylation 1 in tRNA drives liver tumourigenesis by regulating cholesterol metabolism, 范祖森, 2021 Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling, Gu, Yang, Wang, Yanying, He, Luyun, Zhang, Jiahang, Zhu, Xiaoxiao, Liu, Nian, Wang, Jianyi, Lu, Tiankun, He, Lei, Tian, Yong, Fan, Zusen, 2021 Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity, Ye, Buqing, Yang, Liuliu, Liu, Benyu, Liu, Nian, Fan, Dongdong, Li, Huimu, Sun, Lei, Du, Ying, Wang, Shuo, Tian, Yong, Fan, Zusen, 2022

Areas of Focus

Discovery of new subsets in innate immunity and mechanisms against infection/tumor
Non-coding RNA and immune regulation
Tumor stem cells and tumor immunity

Publications

Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability, Guo, Hui, Zhang, Jiahang, Jiang, Zhimin, Zhu, Xiaoxiao, Yang, Jing, Mu, Rui, Du, Ying, Tian, Yong, Zhu, Pingping, Fan, Zusen, 2023
FOXO1 orchestrates the intestinal homeostasis via neuronal signaling in group 3 innate lymphoid cells, Shao, Fei, Liu, Zhen, Wei, Qinglin, Yu, Dou, Zhao, Min, Zhang, Xusheng, Gao, Xintong, Fan, Zusen, Wang, Shuo, 2023
Noncoding RNAs in tumorigenesis and tumor therapy, Pingping Zhu, Benyu Liu, Zusen Fan, 2023
Regulation of noncoding RNAs in innate lymphoid cells, Liu, Benyu, Zhang, Lingwei, Zhu, Pingping, Fan, Zusen, 2023
5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal, pingping zhu, 范祖森, 2022
Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine, Xiong, Zhen, Zhu, Xiaoxiao, Geng, Jingjing, Xu, Yuwei, Wu, Runyuan, Li, Cunzhen, Fan, Dongdong, Qin, Xiwen, Du, Ying, Tian, Yong, Fan, Zusen, 2022
circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription, 范祖森, Nian Liu, 2022
Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity, Ye, Buqing, Yang, Liuliu, Liu, Benyu, Liu, Nian, Fan, Dongdong, Li, Huimu, Sun, Lei, Du, Ying, Wang, Shuo, Tian, Yong, Fan, Zusen, 2022
Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons, Zhu, Pingping, Lu, Tiankun, Wu, Jiayi, Fan, Dongdong, Liu, Benyu, Zhu, Xiaoxiao, Guo, Hui, Du, Ying, Liu, Feng, Tian, Yong, Fan, Zusen, 2022
Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF, Chen, Zhenzhen, Lu, Tiankun, Huang, Lan, Wang, Zhiwei, Yan, Zhongyi, Guan, Yubo, Hu, Wenjing, Fan, Zusen, Zhu, Pingping, 2021
Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m(6)A demethylation of Nr4a1 mRNA, Benyu Liu, Nian Liu, Xiaoxiao Zhu, Liuliu Yang, Buqing Ye, Huimu Li, Pingping Zhu, Tiankun Lu, Yong Tian, Zusen Fan, 2021
N1-methyladenosinemethylation 1 in tRNA drives liver tumourigenesis by regulating cholesterol metabolism, 范祖森, 2021
Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling, Gu, Yang, Wang, Yanying, He, Luyun, Zhang, Jiahang, Zhu, Xiaoxiao, Liu, Nian, Wang, Jianyi, Lu, Tiankun, He, Lei, Tian, Yong, Fan, Zusen, 2021
Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity, Ye, Buqing, Yang, Liuliu, Liu, Benyu, Liu, Nian, Fan, Dongdong, Li, Huimu, Sun, Lei, Du, Ying, Wang, Shuo, Tian, Yong, Fan, Zusen, 2022

Innate Immunity Infection Tumor Non-Coding Rna Immune Regulation Tumor Stem Cells Tumor Immunity Subsets Mechanisms Discovery

Yi Shi - Shanghai Jiao Tong University

Zusen Fan - University of Chinese Academy of Sciences

Han Xia - University of Chinese Academy of Sciences

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