Professor | Zusen Fan | Asia Growth Partners

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Name	Zusen Fan
Language ability	English, Chinese
Province	Beijing

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Name

Zusen Fan

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1998 - PhD in Immunology: Shanghai Jiao Tong University School of Medicine 2003 - Lecturer: Harvard Medical School 2004 - Researcher: Institute of Biophysics, Chinese Academy of Sciences 2005 - Recipient: Distinguished Youth Fund 2006 - Selected: National New Century Talent Project 2010 - Expert: State Council Special Allowance 2014 - Recipient: Tan Jiazhen Life Science Innovation Award 2016, 2018 - Excellent Graduate Advisor: Chinese Academy of Sciences 2018 - Recipient: Beijing Science and Technology Progress First Prize 2019 - Chief Scientist: National Natural Science Foundation Innovation Group 2020 - Chief Scientist: National Key R&D Program
Work Experience	2003 - 2004 - Lecturer: Harvard Medical School 2004 - Present - Researcher: Institute of Biophysics, Chinese Academy of Sciences
Awards	2009 - Beijing Natural Science Award, Third Prize 2014 - Tan Jiazhen Life Science Innovation Award 2018 - Beijing Science and Technology Progress First Prize

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1998 - PhD in Immunology: Shanghai Jiao Tong University School of Medicine
2003 - Lecturer: Harvard Medical School
2004 - Researcher: Institute of Biophysics, Chinese Academy of Sciences
2005 - Recipient: Distinguished Youth Fund
2006 - Selected: National New Century Talent Project
2010 - Expert: State Council Special Allowance
2014 - Recipient: Tan Jiazhen Life Science Innovation Award
2016, 2018 - Excellent Graduate Advisor: Chinese Academy of Sciences
2018 - Recipient: Beijing Science and Technology Progress First Prize
2019 - Chief Scientist: National Natural Science Foundation Innovation Group
2020 - Chief Scientist: National Key R&D Program

Work Experience

2003 - 2004 - Lecturer: Harvard Medical School
2004 - Present - Researcher: Institute of Biophysics, Chinese Academy of Sciences

Awards

2009 - Beijing Natural Science Award, Third Prize
2014 - Tan Jiazhen Life Science Innovation Award
2018 - Beijing Science and Technology Progress First Prize

Areas of Focus	Discovery of new subsets in innate immunity and mechanisms against infection/tumor Non-coding RNA and immune regulation Tumor stem cells and tumor immunity
Publications	Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability, Guo, Hui, Zhang, Jiahang, Jiang, Zhimin, Zhu, Xiaoxiao, Yang, Jing, Mu, Rui, Du, Ying, Tian, Yong, Zhu, Pingping, Fan, Zusen, 2023 FOXO1 orchestrates the intestinal homeostasis via neuronal signaling in group 3 innate lymphoid cells, Shao, Fei, Liu, Zhen, Wei, Qinglin, Yu, Dou, Zhao, Min, Zhang, Xusheng, Gao, Xintong, Fan, Zusen, Wang, Shuo, 2023 Noncoding RNAs in tumorigenesis and tumor therapy, Pingping Zhu, Benyu Liu, Zusen Fan, 2023 Regulation of noncoding RNAs in innate lymphoid cells, Liu, Benyu, Zhang, Lingwei, Zhu, Pingping, Fan, Zusen, 2023 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal, pingping zhu, 范祖森, 2022 Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine, Xiong, Zhen, Zhu, Xiaoxiao, Geng, Jingjing, Xu, Yuwei, Wu, Runyuan, Li, Cunzhen, Fan, Dongdong, Qin, Xiwen, Du, Ying, Tian, Yong, Fan, Zusen, 2022 circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription, 范祖森, Nian Liu, 2022 Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity, Ye, Buqing, Yang, Liuliu, Liu, Benyu, Liu, Nian, Fan, Dongdong, Li, Huimu, Sun, Lei, Du, Ying, Wang, Shuo, Tian, Yong, Fan, Zusen, 2022 Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons, Zhu, Pingping, Lu, Tiankun, Wu, Jiayi, Fan, Dongdong, Liu, Benyu, Zhu, Xiaoxiao, Guo, Hui, Du, Ying, Liu, Feng, Tian, Yong, Fan, Zusen, 2022 Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF, Chen, Zhenzhen, Lu, Tiankun, Huang, Lan, Wang, Zhiwei, Yan, Zhongyi, Guan, Yubo, Hu, Wenjing, Fan, Zusen, Zhu, Pingping, 2021 Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m(6)A demethylation of Nr4a1 mRNA, Benyu Liu, Nian Liu, Xiaoxiao Zhu, Liuliu Yang, Buqing Ye, Huimu Li, Pingping Zhu, Tiankun Lu, Yong Tian, Zusen Fan, 2021 N1-methyladenosinemethylation 1 in tRNA drives liver tumourigenesis by regulating cholesterol metabolism, 范祖森, 2021 Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling, Gu, Yang, Wang, Yanying, He, Luyun, Zhang, Jiahang, Zhu, Xiaoxiao, Liu, Nian, Wang, Jianyi, Lu, Tiankun, He, Lei, Tian, Yong, Fan, Zusen, 2021 N-1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism, Wang, Yanying, Wang, Jing, Li, Xiaoyu, Xiong, Xushen, Wang, Jianyi, Zhou, Ziheng, Zhu, Xiaoxiao, Gu, Yang, Dominissini, Dan, He, Lei, Tian, Yong, Yi, Chengqi, Fan, Zusen, 2021 Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signalling, 范祖森, 2021 The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells, Ye, Buqing, Yang, Liuliu, Qian, Guomin, Liu, Benyu, Zhu, Xiaoxiao, Zhu, Pingping, Ma, Jing, Xie, Wei, Li, Huimu, Lu, Tianku, Wang, Yanying, Wang, Shuo, Du, Ying, Wang, Zhimin, Jiang, Jing, Li, Jinsong, Fan, Dongdong, Meng, Shu, Wu, Jiayi, Tian, Yong, Fan, Zusen, 2020 The chromatin remodeler SRCAP promotes self‐renewal of intestinal stem cells, Buqing Ye, Liuliu Yang, Guomin Qian, Benyu Liu, Xiaoxiao Zhu, Pingping Zhu, Jing Ma, Wei Xie, Huimu Li, Tianku Lu, Yanying Wang, Shuo Wang, Ying Du, Zhimin Wang, Jing Jiang, Jinsong Li, Dongdong Fan, Shu Meng, Jiayi Wu, Yong Tian, Zusen Fan, 2020 Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer, Wang, Shuo, Qu, Yuan, Xia, Pengyan, Chen, Yi, Zhu, Xiaoxiao, Zhang, Jing, Wang, Guan, Tian, Yong, Ying, Jianming, Fan, Zusen, 2020 An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution, Benyu Liu, Buqing Ye, Xiaoxiao Zhu, Liuliu Yang, Huimu Li, Nian Liu, Pingping Zhu, Tiankun Lu, Luyun He, Yong Tian, Zusen Fan, 2020 Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis, Xiong, Zhen, Xia, Pengyan, Zhu, Xiaoxiao, Geng, Jingjing, Wang, Shuo, Ye, Buqing, Qin, Xiwen, Qu, Yuan, He, Luyun, Fan, Dongdong, Du, Ying, Tian, Yong, Fan, Zusen, 2020 IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3, Zhu, Pingping, Zhu, Xiaoxiao, Wu, Jiayi, He, Luyun, Lu, Tiankun, Wang, Yanying, Liu, Benyu, Ye, Buqing, Sun, Lei, Fan, Dongdong, Wang, Jing, Yang, Liuliu, Qin, Xiwen, Du, Ying, Li, Chong, He, Lei, Ren, Weizheng, Wu, Xin, Tian, Yong, Fan, Zusen, 2019 环状RNA抑制了cGAS介导的造血干细胞衰竭, 夏朋延, 王硕, Buqing, Ye, Ying, Du, 李翀, Zhen, Xiong, Yuan, Qu, 范祖森, 2019 Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis, Zhen Xiong, Pengyan Xia, Xiaoxiao Zhu, Jingjing Geng, Shuo Wang, Buqing Ye, Xiwen Qin, Yuan Qu, Luyun He, Dongdong Fan, Ying Du, Yong Tian, Zusen Fan, 2019 Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription, Liu, Benyu, Yang, Liuliu, Zhu, Xiaoxiao, Li, Huimu, Zhu, Pingping, Wu, Jiayi, Lu, Tiankun, He, Luyun, Liu, Nian, Meng, Shu, Zhou, Liang, Ye, Buqing, Tian, Yong, Fan, Zusen, 2019 Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription, Benyu Liu, Liuliu Yang, Xiaoxiao Zhu, Huimu Li, Pingping Zhu, Jiayi Wu, Tiankun Lu, Luyun He, Nian Liu, Shu Meng, Liang Zhou, Buqing Ye, Yong Tian, Zusen Fan, 2019 SPRY4 is responsible for pathogenesis of adolescent idiopathic scoliosis by contributing to osteogenic differentiation and melatonin response of bone marrow-derived mesenchymal stem cells, Li, Jing, Li, Na, Chen, Yunfei, Hui, Shangyi, Fan, Junfen, Ye, Buqing, Fan, Zusen, Zhang, Jianguo, Zhao, Robert Chunhua, Zhuang, Qianyu, 2019 A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity, Song, Xiaosheng, Yang, Liuliu, Wang, Mingzhu, Gu, Yue, Ye, Buqing, Fan, Zusen

Areas of Focus

Discovery of new subsets in innate immunity and mechanisms against infection/tumor
Non-coding RNA and immune regulation
Tumor stem cells and tumor immunity

Publications

Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability, Guo, Hui, Zhang, Jiahang, Jiang, Zhimin, Zhu, Xiaoxiao, Yang, Jing, Mu, Rui, Du, Ying, Tian, Yong, Zhu, Pingping, Fan, Zusen, 2023
FOXO1 orchestrates the intestinal homeostasis via neuronal signaling in group 3 innate lymphoid cells, Shao, Fei, Liu, Zhen, Wei, Qinglin, Yu, Dou, Zhao, Min, Zhang, Xusheng, Gao, Xintong, Fan, Zusen, Wang, Shuo, 2023
Noncoding RNAs in tumorigenesis and tumor therapy, Pingping Zhu, Benyu Liu, Zusen Fan, 2023
Regulation of noncoding RNAs in innate lymphoid cells, Liu, Benyu, Zhang, Lingwei, Zhu, Pingping, Fan, Zusen, 2023
5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal, pingping zhu, 范祖森, 2022
Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine, Xiong, Zhen, Zhu, Xiaoxiao, Geng, Jingjing, Xu, Yuwei, Wu, Runyuan, Li, Cunzhen, Fan, Dongdong, Qin, Xiwen, Du, Ying, Tian, Yong, Fan, Zusen, 2022
circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription, 范祖森, Nian Liu, 2022
Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity, Ye, Buqing, Yang, Liuliu, Liu, Benyu, Liu, Nian, Fan, Dongdong, Li, Huimu, Sun, Lei, Du, Ying, Wang, Shuo, Tian, Yong, Fan, Zusen, 2022
Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons, Zhu, Pingping, Lu, Tiankun, Wu, Jiayi, Fan, Dongdong, Liu, Benyu, Zhu, Xiaoxiao, Guo, Hui, Du, Ying, Liu, Feng, Tian, Yong, Fan, Zusen, 2022
Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF, Chen, Zhenzhen, Lu, Tiankun, Huang, Lan, Wang, Zhiwei, Yan, Zhongyi, Guan, Yubo, Hu, Wenjing, Fan, Zusen, Zhu, Pingping, 2021
Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m(6)A demethylation of Nr4a1 mRNA, Benyu Liu, Nian Liu, Xiaoxiao Zhu, Liuliu Yang, Buqing Ye, Huimu Li, Pingping Zhu, Tiankun Lu, Yong Tian, Zusen Fan, 2021
N1-methyladenosinemethylation 1 in tRNA drives liver tumourigenesis by regulating cholesterol metabolism, 范祖森, 2021
Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling, Gu, Yang, Wang, Yanying, He, Luyun, Zhang, Jiahang, Zhu, Xiaoxiao, Liu, Nian, Wang, Jianyi, Lu, Tiankun, He, Lei, Tian, Yong, Fan, Zusen, 2021
N-1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism, Wang, Yanying, Wang, Jing, Li, Xiaoyu, Xiong, Xushen, Wang, Jianyi, Zhou, Ziheng, Zhu, Xiaoxiao, Gu, Yang, Dominissini, Dan, He, Lei, Tian, Yong, Yi, Chengqi, Fan, Zusen, 2021
Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signalling, 范祖森, 2021
The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells, Ye, Buqing, Yang, Liuliu, Qian, Guomin, Liu, Benyu, Zhu, Xiaoxiao, Zhu, Pingping, Ma, Jing, Xie, Wei, Li, Huimu, Lu, Tianku, Wang, Yanying, Wang, Shuo, Du, Ying, Wang, Zhimin, Jiang, Jing, Li, Jinsong, Fan, Dongdong, Meng, Shu, Wu, Jiayi, Tian, Yong, Fan, Zusen, 2020
The chromatin remodeler SRCAP promotes self‐renewal of intestinal stem cells, Buqing Ye, Liuliu Yang, Guomin Qian, Benyu Liu, Xiaoxiao Zhu, Pingping Zhu, Jing Ma, Wei Xie, Huimu Li, Tianku Lu, Yanying Wang, Shuo Wang, Ying Du, Zhimin Wang, Jing Jiang, Jinsong Li, Dongdong Fan, Shu Meng, Jiayi Wu, Yong Tian, Zusen Fan, 2020
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer, Wang, Shuo, Qu, Yuan, Xia, Pengyan, Chen, Yi, Zhu, Xiaoxiao, Zhang, Jing, Wang, Guan, Tian, Yong, Ying, Jianming, Fan, Zusen, 2020
An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution, Benyu Liu, Buqing Ye, Xiaoxiao Zhu, Liuliu Yang, Huimu Li, Nian Liu, Pingping Zhu, Tiankun Lu, Luyun He, Yong Tian, Zusen Fan, 2020
Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis, Xiong, Zhen, Xia, Pengyan, Zhu, Xiaoxiao, Geng, Jingjing, Wang, Shuo, Ye, Buqing, Qin, Xiwen, Qu, Yuan, He, Luyun, Fan, Dongdong, Du, Ying, Tian, Yong, Fan, Zusen, 2020
IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3, Zhu, Pingping, Zhu, Xiaoxiao, Wu, Jiayi, He, Luyun, Lu, Tiankun, Wang, Yanying, Liu, Benyu, Ye, Buqing, Sun, Lei, Fan, Dongdong, Wang, Jing, Yang, Liuliu, Qin, Xiwen, Du, Ying, Li, Chong, He, Lei, Ren, Weizheng, Wu, Xin, Tian, Yong, Fan, Zusen, 2019
环状RNA抑制了cGAS介导的造血干细胞衰竭, 夏朋延, 王硕, Buqing, Ye, Ying, Du, 李翀, Zhen, Xiong, Yuan, Qu, 范祖森, 2019
Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis, Zhen Xiong, Pengyan Xia, Xiaoxiao Zhu, Jingjing Geng, Shuo Wang, Buqing Ye, Xiwen Qin, Yuan Qu, Luyun He, Dongdong Fan, Ying Du, Yong Tian, Zusen Fan, 2019
Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription, Liu, Benyu, Yang, Liuliu, Zhu, Xiaoxiao, Li, Huimu, Zhu, Pingping, Wu, Jiayi, Lu, Tiankun, He, Luyun, Liu, Nian, Meng, Shu, Zhou, Liang, Ye, Buqing, Tian, Yong, Fan, Zusen, 2019
Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription, Benyu Liu, Liuliu Yang, Xiaoxiao Zhu, Huimu Li, Pingping Zhu, Jiayi Wu, Tiankun Lu, Luyun He, Nian Liu, Shu Meng, Liang Zhou, Buqing Ye, Yong Tian, Zusen Fan, 2019
SPRY4 is responsible for pathogenesis of adolescent idiopathic scoliosis by contributing to osteogenic differentiation and melatonin response of bone marrow-derived mesenchymal stem cells, Li, Jing, Li, Na, Chen, Yunfei, Hui, Shangyi, Fan, Junfen, Ye, Buqing, Fan, Zusen, Zhang, Jianguo, Zhao, Robert Chunhua, Zhuang, Qianyu, 2019
A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity, Song, Xiaosheng, Yang, Liuliu, Wang, Mingzhu, Gu, Yue, Ye, Buqing, Fan, Zusen

Innate Immunity Infection Tumor Subsets Mechanisms Non-Coding Rna Immune Regulation Tumor Stem Cells Tumor Immunity Discovery

Yi Shi - Shanghai Jiao Tong University

Zusen Fan - University of Chinese Academy of Sciences

Han Xia - University of Chinese Academy of Sciences

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