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Fei Sun
Life Science
University of Chinese Academy of Sciences
Beijing
Language: Chinese, English
Cryo-Electron Microscopy
3D Reconstruction
Biological Macromolecules
Membrane Proteins
Structural Biology
Molecular Mechanisms
Biological Imaging
Mitochondrial Membranes
Protein Complexes
Electron Microscopy
Areas of Focus
- Cryo-electron microscopy 3D reconstruction
- Structure and function of biological macromolecular complexes and membrane proteins
- Molecular mechanisms of biological membranes dynamics
Work Experience
- 2006/7 - Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
- 2012/7 - Present - Institute of Biophysics, Chinese Academy of Sciences - Director of Biological Imaging Center
Academic Background & Achievements
- 2001-09 to 2006-07 Ph.D.: Tsinghua University
- 1997-09 to 2001-07 Bachelor's: Nanjing University
Publications
- Using integrated correlative cryo-light and electron microscopy to directly observe syntaphilin-immobilized neuronal mitochondria in situ, Wang S., Li S., Ji G., Huang X. and Sun F., 2017
- Accelerating electron tomography reconstruction algorithm ICON with GPU, Chen Y., Wang Z., Zhang J., Li L., Wan X., Sun F., and Zhang F., 2017
- Structural insight into the specific DNA template binding to DnaG primase in Bacteria, Zhou Y., Lou H., Liu Z., Yang M., Pang X., Sun F. and Wang G., 2017
- Molecular details of the PH domain of ACAP1BAR-PH protein binding to PIP-containing membrane, Chan K.C., Lu L., Sun F., Fan J., 2017
- Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase, Chen R., Gao B., Liu, X., Ruan F., Zhang Y., Lou J., Feng K., Wunsch C., Li S.M., Dai J. and Sun F., 2017
- Structural insights into Ca2+ -activated long-range allosteric channel gating of RyR1, Wei R., Wang X., Zhang Y., Mukherjee S., Zhang L., Chen Q., Huang X., Jing S., Liu C., Li S., Wang G., Xu Y., Zhu S., Williams A., Sun F. and Yin C.C., 2016
- Structural characterization of coatomer in its cytosolic state, Wang S., Zhai Y., Pang X., Niu T., Ding Y.H., Dong, M.Q., Hsu W.V. Sun Z. and Sun F., 2016
- FIRT: filtered iterative reconstruction technique with information restoration, Chen Y., Zhang Y., Zhang K., Deng Y., Zhang F. and Sun F., 2016
- ICON: 3D reconstruction with ‘missing-information’ restoration in biological electron tomography, Deng Y., Chen Y., Zhang Y., Wang S., Zhang F. and Sun F., 2016
- An improved cryo-FIB method for fabrication of frozen hydrated lamella, Zhang J., Ji G., Huang X., Xu W. and Sun F., 2016
- Three-dimensional visualization of arsenic stimulated mouse liver sinusoidal by FIB-SEM approach, Li W., Ding W., Ji G., Zhang J. and Sun F., 2016
- A local-optimization refinement algorithm in single particle analysis for macromolecular complex with multiple rigid modules, Shan H., Wang Z., Zhang F., Xiong Y., Yin C.C. and Sun F., 2016
- Crystal structure of E. coli lipoprotein diacylglyceryl transferase, Mao G., Zhao Y., Kang X., Li Z., Zhang Y., Wang X., Sun F., Sankaran, K., and Zhang, X.C., 2016
- A novel mitochondrial carrier protein Mme1 acts as a yeast mitochondrial magnesium exporter, Cui Y., Zhao S., Wang J., Gao B., Fan Q., Sun F. and Zhou B., 2015
- Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids, Ma D.K., Li Z., Lu A.Y., Sun F., Chen S., Rothe M., Menzel R., Sun F. and Horvitz HR., 2015
- Expression, purification, crystallization and crystallographic study of the Aspergillus terreus acromatic prenyltransferase AtaPT, Gao B., Chen R., Liu X., Dai J. and Sun F., 2015
- BrkAutoDisplay: functional display of multiple exogenous proteins on the surface of Escherichia coli by using BrkA autotransporter, Sun F., Pang X., Xie T., Zhai Y., Wang G.G. and Sun F., 2015
- Three-dimensional super-resolution protein localization correlated with vitrified cellular context, Liu B., Xue Y., Zhao W., Chen Y., Fan C., Gu L., Zhang Y., Sun L., Huang X., Ding W., Sun F., Ji W. and Xu T., 2015
- A novel fully automatic scheme for fiducial marker-based alignment in electron tomography, Han R., Wang L., Liu Z., Sun F. and Zhang F., 2015
- A PH Domain in ACAP1 Possesses Key Features of the BAR Domain in Promoting Membrane Curvature, Pang X., Fan J., Zhang Y., Zhang K., Gao B., Ma J., Li J., Deng Y., Zhou Q., Egelman E.H., Hsu V.W. and Sun F., 2014
- Dimerization interface of 3-hydroxyacyl-CoA dehydrogenase tunes the formation of its catalytic intermediate, Xu Y., Li H., Jin YH., Fan J. and Sun F., 2014
- Expression, purification, crystallization and preliminary crystallographic study of the cytoplasmic domain of the mitochondrial dynamics protein MiD51, Ma J. and Sun F., 2014
- Puzzle out the regulation mechanism of PI4KIIα activity, Sun F., Li J. and Chen C., 2014
- Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα, Zhou Q., Li J., Yu H., Zhai Y., Gao Z., Liu Y., Pang X., Zhang L., Schulten K., Sun F. and Chen C., 2014
- C-terminal motif within Sec7 domain regulates guanine nucleotide exchange activity via tuning protein conformation, Qiu B., Zhang K., Wang S., Sun F., 2014
- A marker-free automatic alignment method based scale-invariant features, Han R., Zhang F., Wan X., Fernandez J.J., Sun F. and Liu Z., 2014
- Cryo-EM structures of two bovine adenovirus type 3 intermediates, Cheng, L., Huang, X., Li, X., Xiong, W., Sun, W., Yang, C., Zhang, K., Wang, Y., Liu, H., Huang, X., Ji, G., Sun F., Zheng, C. and Zhu, P., 2014
- Electron Microscopy Reconstruction of Helical Assemblies, Zhang, Y., and Sun F., 2013
- Revealing various coupling of electron transfer and proton pumping in mitochondrial respiratory chain, Sun F., Zhou Q., Pang X., Xu Y. and Rao Z., 2013
- Flexible interweaved termini determine the thermal stability of thermosomes, Zhang K., Wang L., Liu Y., Chan K.Y., Pang X., Schulten K., Dong Z. and Sun F., 2013
- Structural insights into the intrinsic self-assembly of Par-3 N-terminal domain, Zhang Y., Wang W., Chen J., Zhang K., Gao F., Gao B., Zhang S., Dong M., Besenbacher F., Gong W., Zhang M., Sun F. and Feng W., 2013
- Research of Mitochondrial Calcium Transportation, Lu J., Zhai Y. and Sun F., 2013
- Purification, crystallization and preliminary crystallographic analysis of 3-hydroxyacyl-CoA dehydrogenase from Caenorhabditis elegans, Xu Y. and Sun F., 2013
- Expression, purification and preliminary characterization of glucagon receptor extracellular domain, Wu L., Zhai Y., Lu J., Wang Q. and Sun F., 2013
- Changes in the quaternary structure and function of MjHSP16.5 attributable to deletion of the I-X-I motif and introduction of the substitution, R107G in the alpha-crystallin domain, Quinlan R., Zhang Y., Lansbury A., Williamson I., Pohl E. and Sun F., 2013
- Atomic model of rabbit hemorrhagic disease virus by cryo-electron microscopy and crystallography, Wang X., Xu F., Liu J., Gao B., Liu Y., Zhai Y., Ma J., Zhang K., Baker T.S., Schulten K., Zheng D., Pang H. and Sun F., 2013
- Coexistence of ribbon and helical fibrils originating from hIAPP20-29 revealed by quantitative nanomechanical atomic force microscopy, Zhang S., Andreasen M., Nielsen J.T., Liu L., Nielsen E.H., Song J., Ji G., Sun F., Skrydstrup T., Besenbacher F., Nielsen N.C., Otzen D.E and Dong M., 2013
- Identification of SERPINB1 as a physiological inhibitor of human granzyme H, Wang L., Li Q., Wu L., Liu S., Zhang Y., Yang X., Zhu P., Zhang H., Zhang K., Lou J., Liu P., Tong L., Sun F. and Fan Z., 2013
- MicroRNA-124 reduces caveolar density by targeting caveolin-1 in porcine kidney epithelial PK15 cells, Yang S., Liu X., Li, X., Sun S.F., Sun F., Fan B., and Zhao S., 2013
- Contrast Transfer Function Correction Model Based on Sine and Gaussian Modulation and Spline Interpolation, Wang G., Zhang F., Fan L., Sun F. and Liu, Z., 2013
- A fast calculation strategy of density function in ISAF reconstruction algorithm, Wang G., Zhang F., Fan L., Sun F. and Liu, Z., 2013
Awards
- Beishizhang Young Biophysicist Award (2009): Other
- National Excellent Doctoral Dissertation Award (2008): National
- Outstanding Young Person of Central State Organs (2008): National
