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Xueming Li
Life Science
Tsinghua University
Beijing
Language: Chinese, English
Cryo-Electron Microscopy
3D Reconstruction
Structural Biology
Electron Microscopy
Ultra-High Resolution
Biological Structures
Image Processing
Artificial Intelligence
Drug Design
Medical Applications
Areas of Focus
- Theoretical and methodological research in cryo-electron microscopy
- Development and application of cutting-edge electron microscopy technology for ultra-high resolution 3D reconstruction of biological structures
- Application of electron microscopy in structural biology to address significant biological questions
- Development of advanced experimental and image processing analysis techniques, and artificial intelligence technologies for understanding life activities at atomic or molecular levels
- Promotion of cryo-electron microscopy technology in drug design and medical fields
Work Experience
- 2009-2013 - University of California, San Francisco - Postdoctoral Researcher
- 2014-present - Tsinghua University, School of Life Sciences - Assistant Professor, Associate Professor
- 2014-present - Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology - Researcher
Academic Background & Achievements
- 1998-2002 Bachelor: Beijing University of Science and Technology, Department of Material Physics
- 2002-2005 Master: Beijing University of Science and Technology, Department of Material Physics and Chemistry
- 2005-2009 PhD: Institute of Physics, Chinese Academy of Sciences, Condensed Matter Physics
Publications
- Locating cellular contents during cryoFIB milling using cellular secondary-electron imaging, Xueming Li et al., 2023
- CryoFIB milling large tissue samples for cryo-electron tomography, Xueming Li et al., 2023
- EPicker is an exemplar-based continual learning approach for knowledge accumulation in cryoEM particle picking, Xueming Li et al., 2022
- Structure deformation and curvature sensing of PIEZO1 in lipid membranes, Xueming Li et al., 2022
- Unit quaternion description of spatial rotations in 3D electron cryo-microscopy, Xueming Li et al., 2020
- Assembly and Substrate Recognition of Curli Biogenesis System, Xueming Li et al., 2020
- Programming conventional electron microscopes for solving ultrahigh-resolution structures of small and macro-molecules, Xueming Li et al., 2019
- Mechanism of DNA translocation underlying chromatin remodeling by Snf2, Xueming Li et al., 2019
- Using Focus Ion Beam to Prepare Crystal Lamella for Electron Diffraction, Xueming Li et al., 2019
- A particle-filter framework for robust cryoEM 3D reconstruction, Xueming Li et al., 2018
