Xueming Li

Chinese, English

Beijing

Tsinghua University

Life Sciences

• 1998-2002 Bachelor: Beijing University of Science and Technology, Department of Material Physics
• 2002-2005 Master: Beijing University of Science and Technology, Department of Material Physics and Chemistry
• 2005-2009 PhD: Institute of Physics, Chinese Academy of Sciences, Condensed Matter Physics

• 2009-2013 - University of California, San Francisco - Postdoctoral Researcher
• 2014-present - Tsinghua University, School of Life Sciences - Assistant Professor, Associate Professor
• 2014-present - Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology - Researcher

Cryo-electron microscopy theory and methods
Development and application of cutting-edge electron microscopy technology
High-resolution three-dimensional reconstruction of biological structures
Structural biology research
Advanced experimental and image processing analysis techniques
Artificial intelligence in structural analysis
Nanometer to atomic resolution structure from tissue to cell
Understanding the nature of biological activities at atomic or molecular level
Promoting cryo-EM technology in drug design and medical fields

• Locating cellular contents during cryoFIB milling using cellular secondary-electron imaging, Xueming Li, 2023
• CryoFIB milling large tissue samples for cryo-electron tomography, Xueming Li, 2023
• EPicker is an exemplar-based continual learning approach for knowledge accumulation in cryoEM particle picking, Xueming Li, 2022
• Structure deformation and curvature sensing of PIEZO1 in lipid membranes, Xueming Li, 2022
• Unit quaternion description of spatial rotations in 3D electron cryo-microscopy, Xueming Li, 2020
• Assembly and Substrate Recognition of Curli Biogenesis System, Xueming Li, 2020
• Programming conventional electron microscopes for solving ultrahigh-resolution structures of small and macro-molecules, Xueming Li, 2019
• Mechanism of DNA translocation underlying chromatin remodeling by Snf2, Xueming Li, 2019
• Using Focus Ion Beam to Prepare Crystal Lamella for Electron Diffraction, Xueming Li, 2019
• A particle-filter framework for robust cryoEM 3D reconstruction, Xueming Li, 2018