Areas of Focus
- Cryo-electron microscopy theory and methods
- Development and application of cutting-edge electron microscopy technology
- High-resolution three-dimensional reconstruction of biological structures
- Structural biology research
- Advanced experimental and image processing analysis techniques
- Artificial intelligence in structural analysis
- Nanometer to atomic resolution structure from tissue to cell
- Understanding the nature of biological activities at atomic or molecular level
- Promoting cryo-EM technology in drug design and medical fields
Work Experience
- 2009-2013 - University of California, San Francisco - Postdoctoral Researcher
- 2014-present - Tsinghua University, School of Life Sciences - Assistant Professor, Associate Professor
- 2014-present - Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology - Researcher
Academic Background & Achievements
- 1998-2002 Bachelor: Beijing University of Science and Technology, Department of Material Physics
- 2002-2005 Master: Beijing University of Science and Technology, Department of Material Physics and Chemistry
- 2005-2009 PhD: Institute of Physics, Chinese Academy of Sciences, Condensed Matter Physics
Publications
- Locating cellular contents during cryoFIB milling using cellular secondary-electron imaging, Xueming Li, 2023
- CryoFIB milling large tissue samples for cryo-electron tomography, Xueming Li, 2023
- EPicker is an exemplar-based continual learning approach for knowledge accumulation in cryoEM particle picking, Xueming Li, 2022
- Structure deformation and curvature sensing of PIEZO1 in lipid membranes, Xueming Li, 2022
- Unit quaternion description of spatial rotations in 3D electron cryo-microscopy, Xueming Li, 2020
- Assembly and Substrate Recognition of Curli Biogenesis System, Xueming Li, 2020
- Programming conventional electron microscopes for solving ultrahigh-resolution structures of small and macro-molecules, Xueming Li, 2019
- Mechanism of DNA translocation underlying chromatin remodeling by Snf2, Xueming Li, 2019
- Using Focus Ion Beam to Prepare Crystal Lamella for Electron Diffraction, Xueming Li, 2019
- A particle-filter framework for robust cryoEM 3D reconstruction, Xueming Li, 2018
