Professor | Wang Dacheng | Asia Growth Partners

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Name	Wang Dacheng
Contact Information	dcwang@ibp.ac.cn
Language ability	Chinese, English, German
Province	Beijing

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Name

Wang Dacheng

Contact Information

dcwang@ibp.ac.cn

Language ability

Chinese, English, German

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1958-09 to 1963-08 Bachelor's Degree in Biophysics: University of Science and Technology of China
Work Experience	1988-06 to 1988-12 - University of York, Department of Chemistry - Wellcome Trust Research Fellow 1986-10 to Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher 1986-06 to 1990-10 - Institute of Biophysics, Chinese Academy of Sciences - Deputy Director 1982-06 to 1986-10 - Institute of Biophysics, Chinese Academy of Sciences - Associate Researcher 1982-04 to 1984-03 - Max Planck Institute of Biochemistry, Munich - Humboldt Research Fellow 1978-03 to 1982-05 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher 1963-08 to 1978-02 - Institute of Biophysics, Chinese Academy of Sciences - Research Intern
Awards	High-resolution and high-precision insulin and des-pentapeptide insulin crystal structure research (1990): Second Prize, National Level 1.8 Å resolution pig insulin crystal structure determination (1982): Second Prize, National Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1958-09 to 1963-08 Bachelor's Degree in Biophysics: University of Science and Technology of China

Work Experience

1988-06 to 1988-12 - University of York, Department of Chemistry - Wellcome Trust Research Fellow
1986-10 to Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
1986-06 to 1990-10 - Institute of Biophysics, Chinese Academy of Sciences - Deputy Director
1982-06 to 1986-10 - Institute of Biophysics, Chinese Academy of Sciences - Associate Researcher
1982-04 to 1984-03 - Max Planck Institute of Biochemistry, Munich - Humboldt Research Fellow
1978-03 to 1982-05 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher
1963-08 to 1978-02 - Institute of Biophysics, Chinese Academy of Sciences - Research Intern

Awards

High-resolution and high-precision insulin and des-pentapeptide insulin crystal structure research (1990): Second Prize, National Level
1.8 Å resolution pig insulin crystal structure determination (1982): Second Prize, National Level

Areas of Focus	Pathogen Structural Biology Protein Structure, Function, and Molecular Modification (Protein Engineering)
Publications	Pore-forming activity and structural, Wang Dacheng, 2016 Structural Insights into the Molecular Recognition, Wang Dacheng, 2015 Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis, Wang Dacheng, 2014 Crystal structure of L,D-transpeptidase LdtMt2 in complex, Wang Dacheng, 2013 Crystal structures of aprataxin ortholog Hnt3 reveal the structural mechanism for reversal of 5-adenylated DNA, Wang Dacheng, 2011 Crystal Structure of HugZ, a Novel Heme Oxygenase from Helicobacter pylori, Wang Dacheng, 2011 Crystal Structures of a Populus tomentosa 4-Coumarate:CoA Ligase Shed Light on Its Enzymatic Mechanisms, Wang Dacheng, 2010 Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen, Wang Dacheng, 2010 Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure, Wang Dacheng, 2010 Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: a novel adaptor protein involved in human cerebral cavernous malformation, Wang Dacheng, 2010 Structural basis for the tumor cell apoptosis-inducing activity of an antitumor lectin from the edible mushroom Agrocybe aegerita, Wang Dacheng, 2009 Crystal structure of DNA gyrase B domain sheds lights on the mechanism for T-segment navigation, Wang Dacheng, 2009 Crystal structure of Mabinlin II: a novel structural type of sweet proteins and the main structural basis for its sweetness, Wang Dacheng, 2008 Crystal structure of a glutamate/aspartate binding protein complexed with a glutamate molecule: structural basis of ligand specificity at atomic resolution, Wang Dacheng, 2008 Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase, Wang Dacheng, 2007

Areas of Focus

Pathogen Structural Biology
Protein Structure, Function, and Molecular Modification (Protein Engineering)

Publications

Pore-forming activity and structural, Wang Dacheng, 2016
Structural Insights into the Molecular Recognition, Wang Dacheng, 2015
Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis, Wang Dacheng, 2014
Crystal structure of L,D-transpeptidase LdtMt2 in complex, Wang Dacheng, 2013
Crystal structures of aprataxin ortholog Hnt3 reveal the structural mechanism for reversal of 5-adenylated DNA, Wang Dacheng, 2011
Crystal Structure of HugZ, a Novel Heme Oxygenase from Helicobacter pylori, Wang Dacheng, 2011
Crystal Structures of a Populus tomentosa 4-Coumarate:CoA Ligase Shed Light on Its Enzymatic Mechanisms, Wang Dacheng, 2010
Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen, Wang Dacheng, 2010
Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure, Wang Dacheng, 2010
Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: a novel adaptor protein involved in human cerebral cavernous malformation, Wang Dacheng, 2010
Structural basis for the tumor cell apoptosis-inducing activity of an antitumor lectin from the edible mushroom Agrocybe aegerita, Wang Dacheng, 2009
Crystal structure of DNA gyrase B domain sheds lights on the mechanism for T-segment navigation, Wang Dacheng, 2009
Crystal structure of Mabinlin II: a novel structural type of sweet proteins and the main structural basis for its sweetness, Wang Dacheng, 2008
Crystal structure of a glutamate/aspartate binding protein complexed with a glutamate molecule: structural basis of ligand specificity at atomic resolution, Wang Dacheng, 2008
Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase, Wang Dacheng, 2007

Pathogen Structural Biology Protein Structure Molecular Mechanism Disease Defense Protein Engineering Modification Function Biophysics

Yigong Shi - Tsinghua University

Xinquan Wang - Tsinghua University

Senfang Sui - Tsinghua University

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