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Wang Dacheng
Life Science
University of Chinese Academy of Sciences
Beijing
Language: Chinese, English, German
Pathogen
Structural Biology
Protein Structure
Molecular Mechanism
Disease
Defense
Protein Engineering
Modification
Function
Biophysics
Areas of Focus
- Pathogen Structural Biology
- Protein Structure, Function, and Molecular Modification (Protein Engineering)
Work Experience
- 1988-06 to 1988-12 - University of York, Department of Chemistry - Wellcome Trust Research Fellow
- 1986-10 to Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
- 1986-06 to 1990-10 - Institute of Biophysics, Chinese Academy of Sciences - Deputy Director
- 1982-06 to 1986-10 - Institute of Biophysics, Chinese Academy of Sciences - Associate Researcher
- 1982-04 to 1984-03 - Max Planck Institute of Biochemistry, Munich - Humboldt Research Fellow
- 1978-03 to 1982-05 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher
- 1963-08 to 1978-02 - Institute of Biophysics, Chinese Academy of Sciences - Research Intern
Academic Background & Achievements
- 1958-09 to 1963-08 Bachelor's Degree in Biophysics: University of Science and Technology of China
Publications
- Pore-forming activity and structural, Wang Dacheng, 2016
- Structural Insights into the Molecular Recognition, Wang Dacheng, 2015
- Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis, Wang Dacheng, 2014
- Crystal structure of L,D-transpeptidase LdtMt2 in complex, Wang Dacheng, 2013
- Crystal structures of aprataxin ortholog Hnt3 reveal the structural mechanism for reversal of 5-adenylated DNA, Wang Dacheng, 2011
- Crystal Structure of HugZ, a Novel Heme Oxygenase from Helicobacter pylori, Wang Dacheng, 2011
- Crystal Structures of a Populus tomentosa 4-Coumarate:CoA Ligase Shed Light on Its Enzymatic Mechanisms, Wang Dacheng, 2010
- Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen, Wang Dacheng, 2010
- Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure, Wang Dacheng, 2010
- Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: a novel adaptor protein involved in human cerebral cavernous malformation, Wang Dacheng, 2010
- Structural basis for the tumor cell apoptosis-inducing activity of an antitumor lectin from the edible mushroom Agrocybe aegerita, Wang Dacheng, 2009
- Crystal structure of DNA gyrase B domain sheds lights on the mechanism for T-segment navigation, Wang Dacheng, 2009
- Crystal structure of Mabinlin II: a novel structural type of sweet proteins and the main structural basis for its sweetness, Wang Dacheng, 2008
- Crystal structure of a glutamate/aspartate binding protein complexed with a glutamate molecule: structural basis of ligand specificity at atomic resolution, Wang Dacheng, 2008
- Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase, Wang Dacheng, 2007
Awards
- High-resolution and high-precision insulin and des-pentapeptide insulin crystal structure research (1990): Second Prize, National Level
- 1.8 Å resolution pig insulin crystal structure determination (1982): Second Prize, National Level
