Areas of Focus
- Oxidative Protein Folding in the Endoplasmic Reticulum
- Protein Quality Control Mechanisms
Work Experience
- 1998-02 to 1998-04 - Hong Kong University of Science and Technology - Visiting Professor
- 1995-05 to 1995-08 - University of Göttingen, Germany - Visiting Scientist
- 1991-05 to 1993-01 - University of Alberta, Canada - Research Associate
- 1988-08 to 1991-04 - U.S. Food and Drug Administration - Visiting Scientist
- 1987-05 to 1988-07 - City of Hope National Medical Center, USA - Visiting Scientist
- 1981-02 to 1982-05 - National Institutes of Health, USA - Fogarty Visiting Scholar
- 1979-02 to 1981-02 - German Wool Research Institute - Humboldt Visiting Scholar
- 1964-07 to Present - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher, Researcher, Doctoral Supervisor
Academic Background & Achievements
- 1959-09 to 1964-07 Bachelor's Degree: University of Science and Technology of China
Publications
- Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum, Wang, Lei, Wang, Chihchen, 2023
- Reducing oxidative protein folding alleviates senescence by minimizing ER-to-nucleus H2O2 release, Cheng, Fang, Ji, Qianzhao, Wang, Lu, Wang, Chihchen, Liu, GuangHui, Wang, Lei, 2023
- “后AlphaFold时代”的蛋白质折叠问题, 胡昕炜, 王志珍, 王磊, 2023
- SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductases, Ping Liu, Xi Wang, Yiwei Sun, Hongyu Zhao, Fang Cheng, Jifeng Wang, Fuquan Yang, Junjie Hu, Hong Zhang, Chihchen Wang, Lei Wang, 2022
- Two protein disulfide isomerase subgroups work synergistically in catalyzing oxidative protein folding, Fenggui Fan, Qiao Zhang, Yini Zhang, Guozhong Huang, Xuelian Liang, Chih-Chen Wang, Lei Wang, Dongping Lu, 2022
- The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential, Lu Wang, Xi Wang, Xiying Lv, Qiushuo Jin, Hongcai Shang, Chih-chen Wang, Lei Wang, 2022
- Protein disulfide isomerase is regulated in multiple ways: Consequences for conformation, activities, and pathophysiological functions, Wang, Lei, Yu, Jiaojiao, Wang, Chihchen, 2021
- Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization, Xinxin Chen, Jianchao Zhang, Pulan Liu, Yangyang Wei, Xie Wang, Junyu Xiao, Chihchen Wang, Lei Wang, 2021
- Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress, Yu, Jiaojiao, Li, Tao, Liu, Yu, Wang, Xi, Zhang, Jianchao, Wang, Xie, Shi, Guizhi, Lou, Jizhong, Wang, Likun, Wang, Chihchen, VVang, Lei, 2020
- AtERO1 and AtERO2 Exhibit Differences in Catalyzing Oxidative Protein Folding in the Endoplasmic Reticulum, Fan, Fenggui, Zhang, Yini, Huang, Guozhong, Zhang, Qiao, Wang, Chihchen, Wang, Lei, Lu, Dongping, 2019
- The b ' domain of protein disulfide isomerase cooperates with the a and a ' domains to functionally interact with platelets, Wang, Lu, Zhou, Junsong, Wang, Lei, Wang, Chihchen, Essex, David W., 2019
- Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis, Wu, Xun, Zhang, Lihui, Miao, Yutong, Yang, Juan, Wang, Xian, Wang, Chihchen, Feng, Juan, Wang, Lei, 2019
- Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes, Xu, Shili, Liu, Yajing, Yang, Kai, Wang, Hanxiao, Shergalis, Andrea, Kyani, Anahita, Bankhead, Armand, III, Tamura, Shuzo, Yang, Suhui, Wang, Xi, Wang, Chihchen, Rehemtulla, Alnawaz, Ljungman, Mats, Neamati, Nouri, 2019
- Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1 alpha and protein disulfide isomerase suppresses the progression of cervical cancer, Zhang, Yini, Li, Tao, Zhang, Lihui, Shangguan, Fugen, Shi, Guizhi, Wu, Xun, Cui, Ya, Wang, Xie, Wang, Xi, Liu, Yongzhang, Lu, Bin, Wei, Taotao, Wang, Chihchen, Wang, Lei, 2019
- Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7, Fang, Jingqi, Yang, Jiping, Wu, Xun, Zhang, Gangming, Li, Tao, Wang, Xie, Zhang, Hong, Wang, Chihchen, Liu, GuangHui, Wang, Lei, 2018
- Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity, Li, Huanhuan, Yang, Kai, Wang, Wenjia, Niu, Yingbo, Li, Jun, Dong, Yuhui, Liu, Yingfang, Wang, Chihchen, Wang, Lei, Liang, Huanhuan, 2018
- Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1 alpha, Zhang, Jianchao, Zhu, Qinyu, Wang, Xie, Yu, Jiaojiao, Chen, Xinxin, Wang, Jifeng, Wang, Xi, Xiao, Junyu, Wang, Chihchen, Wang, Lei, 2018
- Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention, Yang, Kai, Li, DeFeng, Wang, Xie, Liang, Jinzhao, Sitia, Roberto, Wang, Chihchen, Wang, Xi, 2016
- Novel Roles of the Non-catalytic Elements of Yeast Protein-disulfide Isomerase in Its Interplay with Endoplasmic Reticulum Oxidoreductin 1, Niu, Yingbo, Zhang, Lihui, Yu, Jiaojiao, Wang, Chihchen, Wang, Lei, 2016
- Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone, Wang, Lei, Wang, Xi, Wang, Chihchen, 2015
- 未折叠蛋白响应：2014年拉斯克基础医学研究奖解读, 王曦, 王磊, 陈畅, 王志珍, 2014
- Different Interaction Modes for Protein-disulfide Isomerase (PDI) as an Efficient Regulator and a Specific Substrate of Endoplasmic Reticulum Oxidoreductin-1 alpha (Ero1 alpha), Zhang, Lihui, Niu, Yingbo, Zhu, Li, Fang, Jingqi, Wang, Xie, Wang, Lei, Wang, Chihchen, 2014
- Glutathione Peroxidase 7 Utilizes Hydrogen Peroxide Generated by Ero1 alpha to Promote Oxidative Protein Folding, Wang, Lei, Zhang, Lihui, Niu, Yingbo, Sitia, Roberto, Wang, Chihchen, 2014
- A Novel Reaction of Peroxiredoxin 4 towards Substrates in Oxidative Protein Folding, Zhu, Li, Yang, Kai, Wang, Xie, Wang, Xi, Wang, Chihchen, 2014
- Compact Conformations of Human Protein Disulfide Isomerase, Yang, Shang, Wang, Xi, Cui, Lei, Ding, Xiang, Niu, Lili, Yang, Fuquan, Wang, Chao, Wang, Chihchen, Lou, Jizhong, 2014
- Structural Insights into the Redox-Regulated Dynamic Conformations of Human Protein Disulfide Isomerase, Wang, Chao, Li, Wei, Ren, Jinqi, Fang, Jingqi, Ke, Huimin, Gong, Weimin, Feng, Wei, Wang, Chihchen, 2013
- Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4, Wang, Xi, Wang, Likun
Awards
- Sixth National Top Ten Women, National Level, 2007
- Ho Leung Ho Lee Foundation Science and Technology Progress Award, Other, 2005
- Second Prize of National Natural Science Award, National Level, 2002
- Third World Academy of Sciences Basic Science (Biology) Award, Other, 2002
- First Prize of Chinese Academy of Sciences Natural Science Award, Other, 1999
- Second Prize of National Natural Science Award, National Level, 1995
