Haiteng Deng

dht@mail.tsinghua.edu.cn

English, Chinese

Beijing

Tsinghua University

Life Sciences

• 1985 Bachelor: Wuhan University
• 1988 Master: Wuhan University
• 1996 PhD: Pennsylvania State University
• Postdoctoral Research: University of Alberta, Oak Ridge National Laboratory

• 1/2000-12/2001 Lecturer, Department of Developmental Biology, Albert Einstein College of Medicine
• 12/2001-7/2003 Assistant Professor, Department of Medicine, Albert Einstein College of Medicine
• 8/2003-12/2003 Assistant Professor, University of Nebraska
• 1/2004-7/2009 Research Assistant Professor, Rockefeller University
• 9/2009-2/2011 Research Associate Professor and Director of Proteomics Center, Rockefeller University
• 9/2008-Present Visiting Researcher, New York University
• 3/2011-Present Visiting Professor, Rockefeller University
• 3/2011-Present Professor (since 2017), Tsinghua University

Development and application of proteomics, metabolomics, and chemical biology techniques and methods
Study of redox biology in aging and disease
Development of biomarkers for aging and related diseases
Development of natural small molecules, nanobodies, and vaccines to extend health lifespan
Study of pathogen-host cell interactions
Identification of early diagnostic markers for tumors and study of protein drug modifications and mechanisms

• Flavonoid 4,4'-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy, Wang T, Yang C, Li Z, Li T, Zhang R, Zhao Y, Cheng T, Zong Z, Ma Y, Zhang D, Deng H., 2024
• Supplementation of nicotinamide mononucleotide diminishes COX-2 associated inflammatory responses in macrophages by activating kynurenine/AhR signaling, Liu J, Hou W, Zong Z, Chen Y, Liu X, Zhang R, Deng H., 2024
• Oxidative degradation of dihydrofolate reductase increases CD38-mediated ferroptosis susceptibility, Yingying Ma; Meiqi Yi; Weixuan Wang; Xiaohui Liu; Qingtao Wang; Chongdong Liu; Yuling Chen; Haiteng Deng, 2022
• Complex roles of nicotinamide N-methyltransferase in cancer progression, Wang W, Yang C, Wang T, Deng H., 2022
• Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3-Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury, Luo C, Ding W, Yang C, Zhang W, Liu X, Deng H., 2022
• High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumour Cells, Songbiao Zhu; Wenxi Ding; Yuling Chen; Weixuan Wang; Renhua Xu; Chongdong Liu; Xiaohui Liu; Haiteng Deng, 2021
• Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+, Suppresses Glycolysis, TCA Cycle and Cell Growth, Liu, Yan; Luo, Chengting; Li, Ting; Zhang, Wenhao; Zong, Zhaoyun; Liu, Xiaohui; Deng, Haiteng, 2021
• Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting, Jin J, Meng X, Huo Y, Deng H., 2021
• Flavonoid 4,4'-dimethoxychalcone suppresses cell proliferation via dehydrogenase inhibition and oxidative stress aggravation, Yang C, Zhu S, Chen Y, Liu Z, Zhang W, Zhao C, Luo C, Deng H., 2021
• Comparative proteomic analysis identifies biomarkers for renal aging, Meiqi Yi, Yingying Ma, Songbiao Zhu, Chengting Luo, Yuling Chen, Qingtao Wang, Haiteng Deng, 2020
• Glutathionylation decreases methyltransferase activity of PRMT5 and inhibits cell proliferation, Meiqi Yi, Yingying Ma, Yuling Chen, Chongdong Liu, Qingtao Wang, and Haiteng Deng, 2020
• Development of a dual-functional conjugate of antigenic peptide and Fc-III mimetics for targeted antibody blocking, Zhang, Lin; Shen, Hao; Gong, Yiyi; Pang, Xiaojing; Yi, Meiqi; Guo, Lin; Li, Jin; Arroyo, Sam; Lu, Xin; Ovchinnikov, Sergey; Cheng, Gong; Liu, Xudong; Jiang, Xu; Feng, Shan; Deng, Haiteng, 2019
• HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells, Teng, Ruifang; Liu, Zhilei; Tang, Haiping; Zhang, Wenhao; Chen, Yuling; Xu, Rrenhua; Chen, Liang; Song, Jiangping; Liu, Xiaohui; Deng, Haiteng, 2019
• Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition, Wang, Weixuan; Hu, Yadong; Yang, Changmei; Zhu, Songbiao; Wang, Xiaofei; Zhang, Zhenyu; Deng, Haiteng, 2018
• ROS-mediated 15-Hydroxyprostaglandin Dehydrogenase Degradation via Cysteine Oxidation Promotes NAD+-Mediated Epithelial-Mesenchymal Transition, Wang, Weixuan; Hu, Yadong; Wang, Xiaofei; Wang, Qingtao; Deng, Haiteng, 2018