Areas of Focus
- Cell signaling research, aging and Alzheimer's disease pathogenesis, and related innovative drug discovery
- Stem cell fate regulation and related small molecule drug discovery
Work Experience
- 2004-2007 - Max Planck Institute for Biochemistry, Germany: Postdoctoral Researcher
- 2008-Present - Tongji University, School of Life Sciences and Technology, Shanghai: Associate Professor
Academic Background & Achievements
- 1996 - Bachelor of Medicine: Shanghai Medical University (now Fudan University Medical College)
- 1999 - Master of Medicine: Shanghai Medical University (now Fudan University Medical College)
- 2003 - PhD in Biology: University of Giessen, Germany
- Selected for Shanghai Pujiang Talent Program in 2008
Publications
- Neonatal cortical astrocytes possess intrinsic potential in neuronal conversion in defined media, Zeng P, Hua QH, Gong JY, Shi CJ, Pi XP, Xie X, Zhang R, 2021
- Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs, Li Y, Sun X, Liu H, Huang L, Meng G, Ding Y, Su W, Lu J, Gong S, Terstappen GC, Zhang R, Zhang W, 2019
- Donepezil, a drug for Alzheimer's disease, promotes oligodendrocyte generation and remyelination, Cui X, Guo YE, Fang JH, Shi CJ, Suo N, Zhang R, Xie X, 2019
- One-step generation of mice carrying a conditional allele together with an HA-tag insertion for the delta opioid receptor, Su D, Wang M, Ye C, Fang J, Duan Y, Zhang Z, Hua Q, Shi C, Zhang L, Zhang R, Xie X, 2017
- CXCR4 activation promotes differentiation of human embryonic stem cells to neural stem cells, Zhang L, Hua Q, Tang K, Shi C, Xie X, Zhang R, 2016
- Methuselah regulates longevity via dTOR: a pathway revealed by small-molecule ligands, Wang, Junjie; Wang, Zhilong; Zhang, Zhenghong; Hua, Qiuhong; Wang, Min; Shi, Changjie; Xue, Lei; Zhang, Ru; Xie, Xin, 2015
- Identification of a novel small-molecule agonist for human G protein-coupled receptor 3, Ye C, Zhang Z, Wang Z, Hua Q, Zhang R, Xie X, 2014
- Proliferation rate of somatic cells affects reprogramming efficiency, Yongyu Xu, Xiaoyuan Wei, Min Wang, Ru Zhang, Yanbin Fu, Mingzhe Xing, Qiuhong Hua, Xin Xie, 2013
- iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery, Ru Zhang, Lihong Zhang, Xin Xie, 2013
- Novel Object Recognition as a Facile Behavior Test for Evaluating Drug Effects in A PP/PS1 Alzheimer’s Disease Mouse Model, Ru Zhang, Guizhen Xue, Shaodeng Wang, Lihong Zhang, Changjie Shi, Xin Xie, 2012
- Tools for GPCR Drug Discovery, Ru Zhang, Xin Xie, 2012
- Stress-mediated p38 activation promotes somatic cell reprogramming, Xinxiu Xu, Quan Wang, Yuan Long, Ru Zhang, Xiaoyuan Wei, Mingzhe Xing, Haifeng Gu, Xin Xie, 2012
- Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach, Koch H, Zhang R, Verdoodt B, Bailey A, Zhang CD, Yates 3rd JR, Menssen A, Hermeking H, 2007
- CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin, Burke LJ, Zhang R, Bartkuhn M, Tiwari VK, Tavoosidana G, Kurukuti S, Weth C, Leers J, Galjart N, Ohlsson R, Renkawitz R, 2005
- Dynamic association of the mammalian insulator protein CTCF with centrosomes and the midbody, Zhang R, Burke LJ, Rasko J, Lobanenkov V, Renkawitz R, 2004
