Areas of Focus
- Cell signaling and mechanisms of neurodegenerative diseases
- Mitophagy defects in Alzheimer's disease
- NAD+ and microglial neuroinflammation in Alzheimer's disease
- Genetic and epigenetic decoding of aging and age-related diseases
- Discovery and mechanism of natural active drugs for aging and Alzheimer's disease
Work Experience
- 2015-2021 - National Institutes of Health (NIH), National Institute on Aging (NIA), Postdoctoral Researcher
- 2021-2022 - Tongji University, Distinguished Research Fellow
- 2022-Present - Tongji University, Professor
Academic Background & Achievements
- 2008 - Bachelor of Science: East China Normal University
- 2015 - Doctor of Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- Awards: Butler-Williams Scholar, Nathan Shock Award
Publications
- NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING, Yujun Hou, Yong Wei, Sofie Lautrup, Beimeng Yang, Yue Wang, et al., and Vilhelm A. Bohr, 2021
- Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer's disease, Evandro F. Fang, Yujun Hou, Konstantinos Palikaras, Bryan A. Adriaanse, Jesse S. Kerr, Beimeng Yang, Sofie Lautrup et al. and Vilhelm A. Bohr, 2019
- NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency, Yujun Hou, Sofie Lautrup, Stephanie Cordonnier, Yue Wang, Deborah L. Croteau, et al. and Vilhelm A. Bohr, 2018
- Urolithin A improves Alzheimer’s disease cognition and restores mitophagy and lysosomal functions, Yujun Hou, Xixia Chu, Jae-Hyeon Park, Qing Zhu, Mansoor Hussein, Zhiquan Li, Helena Borland Madsen, Beimeng Yang, Yong Wei, Yue Wang, Evandro Fang, Deborah Croteau, Vilhelm A. Bohr, 2024
- Ageing as a risk factor for neurodegenerative disease, Yujun Hou, Xiuli Dan, Mansi Babbar, Yong Wei et al. and Vilhelm A. Bohr, 2019
- NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome, Evandro F. Fang, Yujun Hou, Sofie Lautrup, Martin Borch Jensen, Beimeng Yang, Tanima SenGupta et al. and Vilhelm A. Bohr, 2019
- RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice, Yujun Hou, Jae-Hyeon Park, Xiuli Dan, Xixia Chu, Beimeng Yang, Mansoor Hussain, Deborah L Croteau, Vilhelm A Bohr, 2023
- Alzheimer’s Amyloid-β Accelerates Cell Senescence and Suppresses SIRT1 in Human Neural Stem Cells, Rongyao Li, Yi Li, Haowei Zuo, Gang Pei, Shichao Huang, Yujun Hou, 2024
- Epigenetic marks or not? The discovery of novel DNA modifications in eukaryotes, Wei-Ying Meng, Zi-Xin Wang, Yunfang Zhang, Yujun Hou, Jian-Huang Xue, 2024
- Roles of NAD+ in Health and Aging, Sofie Lautrup, Yujun Hou, Evandro F Fang, Vilhelm A Bohr, 2024
- Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer’s mouse model, Xixia Chu, Yujun Hou, Qiong Meng, Deborah L Croteau, Yong Wei, Supriyo De, Kevin G Becker, Vilhelm A Bohr, 2022
- Genome instability in Alzheimer disease, Yujun Hou, Hyundong Song, Deborah L. Croteau, Mansour Akbari, Vilhelm A. Bohr, 2017
Awards
- Butler-Williams Scholar
- Nathan Shock Award
