Professor | Yujun Hou | Asia Growth Partners

Name	Yujun Hou
Contact Information	yjhou@tongji.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Yujun Hou

Contact Information

yjhou@tongji.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Tongji University
Faculty	Life Sciences
Academic Background & Achievements	2008 - Bachelor of Science: East China Normal University 2015 - Doctor of Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences Awards: Butler-Williams Scholar, Nathan Shock Award
Work Experience	2015-2021 - National Institutes of Health (NIH), National Institute on Aging (NIA), Postdoctoral Researcher 2021-2022 - Tongji University, Distinguished Research Fellow 2022-Present - Tongji University, Professor
Awards	Butler-Williams Scholar Nathan Shock Award

University/Lab Affiliation and Title

Tongji University

Faculty

Life Sciences

Academic Background & Achievements

2008 - Bachelor of Science: East China Normal University
2015 - Doctor of Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Awards: Butler-Williams Scholar, Nathan Shock Award

Work Experience

2015-2021 - National Institutes of Health (NIH), National Institute on Aging (NIA), Postdoctoral Researcher
2021-2022 - Tongji University, Distinguished Research Fellow
2022-Present - Tongji University, Professor

Awards

Butler-Williams Scholar
Nathan Shock Award

Areas of Focus	Cell signaling and mechanisms of neurodegenerative diseases Mitophagy defects in Alzheimer's disease NAD+ and microglial neuroinflammation in Alzheimer's disease Genetic and epigenetic decoding of aging and age-related diseases Discovery and mechanism of natural active drugs for aging and Alzheimer's disease
Publications	NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING, Yujun Hou, Yong Wei, Sofie Lautrup, Beimeng Yang, Yue Wang, et al., and Vilhelm A. Bohr, 2021 Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer's disease, Evandro F. Fang, Yujun Hou, Konstantinos Palikaras, Bryan A. Adriaanse, Jesse S. Kerr, Beimeng Yang, Sofie Lautrup et al. and Vilhelm A. Bohr, 2019 NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency, Yujun Hou, Sofie Lautrup, Stephanie Cordonnier, Yue Wang, Deborah L. Croteau, et al. and Vilhelm A. Bohr, 2018 Urolithin A improves Alzheimer’s disease cognition and restores mitophagy and lysosomal functions, Yujun Hou, Xixia Chu, Jae-Hyeon Park, Qing Zhu, Mansoor Hussein, Zhiquan Li, Helena Borland Madsen, Beimeng Yang, Yong Wei, Yue Wang, Evandro Fang, Deborah Croteau, Vilhelm A. Bohr, 2024 Ageing as a risk factor for neurodegenerative disease, Yujun Hou, Xiuli Dan, Mansi Babbar, Yong Wei et al. and Vilhelm A. Bohr, 2019 NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome, Evandro F. Fang, Yujun Hou, Sofie Lautrup, Martin Borch Jensen, Beimeng Yang, Tanima SenGupta et al. and Vilhelm A. Bohr, 2019 RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice, Yujun Hou, Jae-Hyeon Park, Xiuli Dan, Xixia Chu, Beimeng Yang, Mansoor Hussain, Deborah L Croteau, Vilhelm A Bohr, 2023 Alzheimer’s Amyloid-β Accelerates Cell Senescence and Suppresses SIRT1 in Human Neural Stem Cells, Rongyao Li, Yi Li, Haowei Zuo, Gang Pei, Shichao Huang, Yujun Hou, 2024 Epigenetic marks or not? The discovery of novel DNA modifications in eukaryotes, Wei-Ying Meng, Zi-Xin Wang, Yunfang Zhang, Yujun Hou, Jian-Huang Xue, 2024 Roles of NAD+ in Health and Aging, Sofie Lautrup, Yujun Hou, Evandro F Fang, Vilhelm A Bohr, 2024 Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer’s mouse model, Xixia Chu, Yujun Hou, Qiong Meng, Deborah L Croteau, Yong Wei, Supriyo De, Kevin G Becker, Vilhelm A Bohr, 2022 Genome instability in Alzheimer disease, Yujun Hou, Hyundong Song, Deborah L. Croteau, Mansour Akbari, Vilhelm A. Bohr, 2017

Areas of Focus

Cell signaling and mechanisms of neurodegenerative diseases
Mitophagy defects in Alzheimer's disease
NAD+ and microglial neuroinflammation in Alzheimer's disease
Genetic and epigenetic decoding of aging and age-related diseases
Discovery and mechanism of natural active drugs for aging and Alzheimer's disease

Publications

NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING, Yujun Hou, Yong Wei, Sofie Lautrup, Beimeng Yang, Yue Wang, et al., and Vilhelm A. Bohr, 2021
Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer's disease, Evandro F. Fang, Yujun Hou, Konstantinos Palikaras, Bryan A. Adriaanse, Jesse S. Kerr, Beimeng Yang, Sofie Lautrup et al. and Vilhelm A. Bohr, 2019
NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency, Yujun Hou, Sofie Lautrup, Stephanie Cordonnier, Yue Wang, Deborah L. Croteau, et al. and Vilhelm A. Bohr, 2018
Urolithin A improves Alzheimer’s disease cognition and restores mitophagy and lysosomal functions, Yujun Hou, Xixia Chu, Jae-Hyeon Park, Qing Zhu, Mansoor Hussein, Zhiquan Li, Helena Borland Madsen, Beimeng Yang, Yong Wei, Yue Wang, Evandro Fang, Deborah Croteau, Vilhelm A. Bohr, 2024
Ageing as a risk factor for neurodegenerative disease, Yujun Hou, Xiuli Dan, Mansi Babbar, Yong Wei et al. and Vilhelm A. Bohr, 2019
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome, Evandro F. Fang, Yujun Hou, Sofie Lautrup, Martin Borch Jensen, Beimeng Yang, Tanima SenGupta et al. and Vilhelm A. Bohr, 2019
RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice, Yujun Hou, Jae-Hyeon Park, Xiuli Dan, Xixia Chu, Beimeng Yang, Mansoor Hussain, Deborah L Croteau, Vilhelm A Bohr, 2023
Alzheimer’s Amyloid-β Accelerates Cell Senescence and Suppresses SIRT1 in Human Neural Stem Cells, Rongyao Li, Yi Li, Haowei Zuo, Gang Pei, Shichao Huang, Yujun Hou, 2024
Epigenetic marks or not? The discovery of novel DNA modifications in eukaryotes, Wei-Ying Meng, Zi-Xin Wang, Yunfang Zhang, Yujun Hou, Jian-Huang Xue, 2024
Roles of NAD+ in Health and Aging, Sofie Lautrup, Yujun Hou, Evandro F Fang, Vilhelm A Bohr, 2024
Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer’s mouse model, Xixia Chu, Yujun Hou, Qiong Meng, Deborah L Croteau, Yong Wei, Supriyo De, Kevin G Becker, Vilhelm A Bohr, 2022
Genome instability in Alzheimer disease, Yujun Hou, Hyundong Song, Deborah L. Croteau, Mansour Akbari, Vilhelm A. Bohr, 2017

Cell Signaling Neurodegenerative Diseases Mitophagy Alzheimer'S Disease Nad+ Neuroinflammation Genetics Epigenetics Aging Natural Active Drugs

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