Professor | Yongliang Zhao | Asia Growth Partners

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Name	Yongliang Zhao
Contact Information	zhaoyongliang@big.ac.cn
Language ability	English, Chinese
Province	Beijing

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Name

Yongliang Zhao

Contact Information

zhaoyongliang@big.ac.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1998-04--2003-04 Postdoctoral: Columbia University 1992-08--1995-07 PhD in Molecular Biology and Toxicology: Beijing Institute of Radiation Medicine 1986-07--1989-08 Master's in Preventive Medicine: Hebei Medical University 1981-09--1986-07 Bachelor's in Medicine: China Medical University
Work Experience	2009-02~Present - Chinese Academy of Sciences Beijing Institute of Genomics - Researcher 2003-05~2009-01 - Columbia University - Assistant Professor 1995-07~1998-04 - Beijing Institute of Radiation Medicine - Assistant Researcher 1989-08~1992-08 - Hebei Medical University Department of Preventive Medicine - Teaching Assistant

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1998-04--2003-04 Postdoctoral: Columbia University
1992-08--1995-07 PhD in Molecular Biology and Toxicology: Beijing Institute of Radiation Medicine
1986-07--1989-08 Master's in Preventive Medicine: Hebei Medical University
1981-09--1986-07 Bachelor's in Medicine: China Medical University

Work Experience

2009-02~Present - Chinese Academy of Sciences Beijing Institute of Genomics - Researcher
2003-05~2009-01 - Columbia University - Assistant Professor
1995-07~1998-04 - Beijing Institute of Radiation Medicine - Assistant Researcher
1989-08~1992-08 - Hebei Medical University Department of Preventive Medicine - Teaching Assistant

Areas of Focus	Genomic variation and molecular mechanisms of tumor progression Mitochondrial homeostasis and neurodegenerative diseases
Publications	Spatiotemporal transcriptomic atlas reveals the dynamic characteristics and key regulators of planarian regeneration., Cui, Guanshen, Dong, Kangning, Zhou, JiaYi, Li, Shang, Wu, Ying, Han, Qinghua, Yao, Bofei, Shen, Qunlun, Zhao, YongLiang, Yang, Ying, Cai, Jun, Zhang, Shihua, Yang, YunGui., 2023 Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis., WenLan Yang, Weinan Qiu, Ting Zhang, Kai Xu, ZiJuan Gu, Yu Zhou, HengJi Xu, ZhongZhou Yang, Bin Shen, YongLiang Zhao, Qi Zhou, Ying Yang, Wei Li, PengYuan Yang, YunGui Yang., 2023 scm 6 A-seq reveals single-cell landscapes of the dynamic m 6 A during oocyte maturation and early embryonic development., Huan Yao, Chun-Chun Gao, Danru Zhang, Jiawei Xu, Gege Song, Xiu Fan, Dao-Bo Liang, Yu-Sheng Chen, Qian Li, Yanjie Guo, Yu-Ting Cai, Lulu Hu, Yong-Liang Zhao, Ying-Pu Sun, Ying Yang, Jianyong Han, Yun-Gui Yang., 2023 Phase separation of Ddx3xb helicase regulates maternal-to-zygotic transition in zebrafish., Shi, Boyang, Heng, Jian, Zhou, JiaYi, Yang, Ying, Zhang, WanYing, Koziol, Magdalena J, Zhao, YongLiang, Li, Pilong, Liu, Feng, Yang, YunGui., 2022 An insight into planarian regeneration., Ge, XinYang, Han, Xiao, Zhao, YongLiang, Cui, GuanShen, Yang, YunGui., 2022 Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation., Zhang, Chuanchao, Zhou, Bo, Gu, Feng, Liu, Hongmei, Wu, Honglin, Yao, Fuwen, Zheng, Hui, Fu, Hui, Chong, Wei, Cai, Shurui, Huang, Min, Ma, Xiaolu, Guo, Zhifang, Li, Tingting, Deng, Wenyuan, Zheng, Meiwen, Ji, Qiao, Zhao, Yongliang, Ma, Yongjie, Wang, QiEn, Tang, TieShan, Guo, Caixia., 2022 Dynamic DNA 5-hydroxylmethylcytosine and RNA 5-methycytosine Reprogramming During Early Human Development., Xiao Han, Jia Guo, Mengke Wang, Nan Zhang, Jie Ren, Ying Yang, Xu Chi, Yusheng Chen, Huan Yao, YongLiang Zhao, YunGui Yang, Yingpu Sun, Jiawei Xu., 2022 Comprehensive analysis of RNA-seq and whole genome sequencing data reveals no evidence for SARS-CoV-2 integrating into host genome., Chen, YuSheng, Lu, Shuaiyao, Zhang, Bing, Du, Tingfu, Li, WenJie, Lei, Meng, Zhou, Yanan, Zhang, Yong, Liu, Penghui, Sun, YongQiao, Zhao, YongLiang, Yang, Ying, Peng, Xiaozhong, Yang, YunGui., 2022 Dynamic transcriptomic m(5)C and its regulatory role in RNA processing., Chen, YuSheng, Yang, WenLan, Zhao, YongLiang, Yang, YunGui., 2021 RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks., Tan, Qunsong, Niu, Kaifeng, Zhu, Yuqi, Chen, Zixiang, Li, Yueyang, Li, Mengge, Wei, Di, Balajee, Adayabalam S, Fang, Hongbo, Zhao, Yongliang., 2021 RNA methylations in human cancers., Han, Xiao, Wang, Mengke, Zhao, YongLiang, Yang, Ying, Yang, YunGui., 2021 RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function., Shi, Boyang, Zhang, Jinsong, Heng, Jian, Gong, Jing, Zhang, Ting, Li, Pan, Sun, BaoFa, Yang, Ying, Zhang, Ning, Zhao, YongLiang, Wang, HaiLin, Liu, Feng, Zhang, Qiangfeng Cliff, Yang, YunGui., 2020 Deubiquitinate USP33 regulates Parkin and antagonizes its role in mitophagy., Zhao Yongliang., 2020 Dynamic methylome of internal mRNA N-7-methylguanosine and its regulatory role in translation., Malbec, Lionel, Zhang, Ting, Chen, YuSheng, Zhang, Ying, Sun, BaoFa, Shi, BoYang, Zhao, YongLiang, Yang, Ying, Yang, YunGui., 2019 RecQL4-Aurora B kinase axis is essential for cellular proliferation, cell cycle progression, and mitotic integrity., Fang, Hongbo, Niu, Kaifeng, Mo, Dongliang, Zhu, Yuqi, Tan, Qunsong, Wei, Di, Li, Yueyang, Chen, Zixiang, Yang, Shuchen, Balajee, Adayabalam S, Zhao, Yongliang., 2018 MMS19 localizes to mitochondria and protects the mitochondrial genome from oxidative damage., Wu, Rui, Tan, Qunsong, Niu, Kaifeng, Zhu, Yuqi, Wei, Di, Zhao, Yongliang, Fang, Hongbo., 2018 Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells., Mo, Dongliang, Zhao, Yongliang, Balajee, Adayabalam S., 2018 Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway., Mo, Dongliang, Fang, Hongbo, Niu, Kaifeng, Liu, Jing, Wu, Meng, Li, Shiyou, Zhu, Tienian, Aleskandarany, Mohammed A, Arora, Arvind, Lobo, Dileep N, Madhusudan, Srinivasan, Balajee, Adayabalam S, Chi, Zhenfen, Zhao, Yongliang., 2016 XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage., Liu, Jing, Fang, Hongbo, Chi, Zhenfen, Wu, Zan, Wei, Di, Mo, Dongliang, Niu, Kaifeng, Balajee, Adayabalam S, Hei, Tom K, Nie, Linghu, Zhao, Yongliang., 2015 Epigenetic regulation of putative tumor suppressor TGFBI in human leukemias., Fang Hongbo, Liu Jing, Guo Dan, Liu Peixiang, Zhao Yongliang., 2014 RecQL4 Helicase Amplification Is Involved in Human Breast Tumorigenesis., Fang, Hongbo, Nie, Linghu, Chi, Zhenfen, Liu, Jing, Guo, Dan, Lu, Xuemei, Hei, Tom K, Balajee, Adayabalam S, Zhao, Yongliang., 2013 RecQL4 cytoplasmic localization: Implications in mitochondrial DNA oxidative damage repair., Chi, Zhenfen, Nie, Linghu, Peng, Zhao, Yang, Qiong, Yang, Kuan, Tao, Jiahai, Mi, Yang, Fang, Xiangdong, Balajee, Adayabalam S, Zhao, Yongliang., 2012 Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis., Su, Yanrong, Meador, Jarah A, Calaf, Gloria M, DeSantis, Luca Proietti, Zhao, Yongliang, Bohr, Vilhelm A, Balajee, Adayabalam S., 2010 TGFBI deficiency predispose mice to spontaneous tumor development., Zhao Yongliang., 2009 Precision Methylome and in vivo Methylation Kinetics Characterization of Klebsiella Pneumoniae., Jing Fu, Ju Zhang, Li Yang, Nan Ding, Liya Yue, Xiangli Zhang, Dandan Lu, Xinmiao Jia, Cuidan Li, Chongye Guo, Zhe Yin, Xiaoyuan Jiang, Yongliang Zhao, Fei Chen, Dongsheng Zhou., 2021

Areas of Focus

Genomic variation and molecular mechanisms of tumor progression
Mitochondrial homeostasis and neurodegenerative diseases

Publications

Spatiotemporal transcriptomic atlas reveals the dynamic characteristics and key regulators of planarian regeneration., Cui, Guanshen, Dong, Kangning, Zhou, JiaYi, Li, Shang, Wu, Ying, Han, Qinghua, Yao, Bofei, Shen, Qunlun, Zhao, YongLiang, Yang, Ying, Cai, Jun, Zhang, Shihua, Yang, YunGui., 2023
Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis., WenLan Yang, Weinan Qiu, Ting Zhang, Kai Xu, ZiJuan Gu, Yu Zhou, HengJi Xu, ZhongZhou Yang, Bin Shen, YongLiang Zhao, Qi Zhou, Ying Yang, Wei Li, PengYuan Yang, YunGui Yang., 2023
scm 6 A-seq reveals single-cell landscapes of the dynamic m 6 A during oocyte maturation and early embryonic development., Huan Yao, Chun-Chun Gao, Danru Zhang, Jiawei Xu, Gege Song, Xiu Fan, Dao-Bo Liang, Yu-Sheng Chen, Qian Li, Yanjie Guo, Yu-Ting Cai, Lulu Hu, Yong-Liang Zhao, Ying-Pu Sun, Ying Yang, Jianyong Han, Yun-Gui Yang., 2023
Phase separation of Ddx3xb helicase regulates maternal-to-zygotic transition in zebrafish., Shi, Boyang, Heng, Jian, Zhou, JiaYi, Yang, Ying, Zhang, WanYing, Koziol, Magdalena J, Zhao, YongLiang, Li, Pilong, Liu, Feng, Yang, YunGui., 2022
An insight into planarian regeneration., Ge, XinYang, Han, Xiao, Zhao, YongLiang, Cui, GuanShen, Yang, YunGui., 2022
Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation., Zhang, Chuanchao, Zhou, Bo, Gu, Feng, Liu, Hongmei, Wu, Honglin, Yao, Fuwen, Zheng, Hui, Fu, Hui, Chong, Wei, Cai, Shurui, Huang, Min, Ma, Xiaolu, Guo, Zhifang, Li, Tingting, Deng, Wenyuan, Zheng, Meiwen, Ji, Qiao, Zhao, Yongliang, Ma, Yongjie, Wang, QiEn, Tang, TieShan, Guo, Caixia., 2022
Dynamic DNA 5-hydroxylmethylcytosine and RNA 5-methycytosine Reprogramming During Early Human Development., Xiao Han, Jia Guo, Mengke Wang, Nan Zhang, Jie Ren, Ying Yang, Xu Chi, Yusheng Chen, Huan Yao, YongLiang Zhao, YunGui Yang, Yingpu Sun, Jiawei Xu., 2022
Comprehensive analysis of RNA-seq and whole genome sequencing data reveals no evidence for SARS-CoV-2 integrating into host genome., Chen, YuSheng, Lu, Shuaiyao, Zhang, Bing, Du, Tingfu, Li, WenJie, Lei, Meng, Zhou, Yanan, Zhang, Yong, Liu, Penghui, Sun, YongQiao, Zhao, YongLiang, Yang, Ying, Peng, Xiaozhong, Yang, YunGui., 2022
Dynamic transcriptomic m(5)C and its regulatory role in RNA processing., Chen, YuSheng, Yang, WenLan, Zhao, YongLiang, Yang, YunGui., 2021
RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks., Tan, Qunsong, Niu, Kaifeng, Zhu, Yuqi, Chen, Zixiang, Li, Yueyang, Li, Mengge, Wei, Di, Balajee, Adayabalam S, Fang, Hongbo, Zhao, Yongliang., 2021
RNA methylations in human cancers., Han, Xiao, Wang, Mengke, Zhao, YongLiang, Yang, Ying, Yang, YunGui., 2021
RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function., Shi, Boyang, Zhang, Jinsong, Heng, Jian, Gong, Jing, Zhang, Ting, Li, Pan, Sun, BaoFa, Yang, Ying, Zhang, Ning, Zhao, YongLiang, Wang, HaiLin, Liu, Feng, Zhang, Qiangfeng Cliff, Yang, YunGui., 2020
Deubiquitinate USP33 regulates Parkin and antagonizes its role in mitophagy., Zhao Yongliang., 2020
Dynamic methylome of internal mRNA N-7-methylguanosine and its regulatory role in translation., Malbec, Lionel, Zhang, Ting, Chen, YuSheng, Zhang, Ying, Sun, BaoFa, Shi, BoYang, Zhao, YongLiang, Yang, Ying, Yang, YunGui., 2019
RecQL4-Aurora B kinase axis is essential for cellular proliferation, cell cycle progression, and mitotic integrity., Fang, Hongbo, Niu, Kaifeng, Mo, Dongliang, Zhu, Yuqi, Tan, Qunsong, Wei, Di, Li, Yueyang, Chen, Zixiang, Yang, Shuchen, Balajee, Adayabalam S, Zhao, Yongliang., 2018
MMS19 localizes to mitochondria and protects the mitochondrial genome from oxidative damage., Wu, Rui, Tan, Qunsong, Niu, Kaifeng, Zhu, Yuqi, Wei, Di, Zhao, Yongliang, Fang, Hongbo., 2018
Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells., Mo, Dongliang, Zhao, Yongliang, Balajee, Adayabalam S., 2018
Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway., Mo, Dongliang, Fang, Hongbo, Niu, Kaifeng, Liu, Jing, Wu, Meng, Li, Shiyou, Zhu, Tienian, Aleskandarany, Mohammed A, Arora, Arvind, Lobo, Dileep N, Madhusudan, Srinivasan, Balajee, Adayabalam S, Chi, Zhenfen, Zhao, Yongliang., 2016
XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage., Liu, Jing, Fang, Hongbo, Chi, Zhenfen, Wu, Zan, Wei, Di, Mo, Dongliang, Niu, Kaifeng, Balajee, Adayabalam S, Hei, Tom K, Nie, Linghu, Zhao, Yongliang., 2015
Epigenetic regulation of putative tumor suppressor TGFBI in human leukemias., Fang Hongbo, Liu Jing, Guo Dan, Liu Peixiang, Zhao Yongliang., 2014
RecQL4 Helicase Amplification Is Involved in Human Breast Tumorigenesis., Fang, Hongbo, Nie, Linghu, Chi, Zhenfen, Liu, Jing, Guo, Dan, Lu, Xuemei, Hei, Tom K, Balajee, Adayabalam S, Zhao, Yongliang., 2013
RecQL4 cytoplasmic localization: Implications in mitochondrial DNA oxidative damage repair., Chi, Zhenfen, Nie, Linghu, Peng, Zhao, Yang, Qiong, Yang, Kuan, Tao, Jiahai, Mi, Yang, Fang, Xiangdong, Balajee, Adayabalam S, Zhao, Yongliang., 2012
Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis., Su, Yanrong, Meador, Jarah A, Calaf, Gloria M, DeSantis, Luca Proietti, Zhao, Yongliang, Bohr, Vilhelm A, Balajee, Adayabalam S., 2010
TGFBI deficiency predispose mice to spontaneous tumor development., Zhao Yongliang., 2009
Precision Methylome and in vivo Methylation Kinetics Characterization of Klebsiella Pneumoniae., Jing Fu, Ju Zhang, Li Yang, Nan Ding, Liya Yue, Xiangli Zhang, Dandan Lu, Xinmiao Jia, Cuidan Li, Chongye Guo, Zhe Yin, Xiaoyuan Jiang, Yongliang Zhao, Fei Chen, Dongsheng Zhou., 2021

Genomic Variation Tumor Progression Molecular Mechanisms Mitochondrial Homeostasis Neurodegenerative Diseases Dna Damage Repair Aging Diseases Cancer Genomics Biochemistry

Qiang Guo - Peking University

Shaojun Dai - Shanghai Normal University

Fang Yu - Shanghai Normal University

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