2009-2014 PhD: Tsinghua University School of Life Sciences
2005-2009 Bachelor: Lanzhou University School of Life Sciences
2020-present Researcher, Peking University-Tsinghua University Center for Life Sciences
2020-present Researcher, Peking University School of Life Sciences
2014-2020 Postdoctoral Researcher, Max Planck Institute of Biochemistry
Beijing Outstanding Young Scientist Fund (2024)
Bayer Scholar (2021)
Boya Young Scholar (2021)
National High-level Talents Introduction Plan (Youth Project) (2020)
Yifang Scholar (2020)
Humboldt Fellowship (2016-2017)
EMBO Long-term Fellowship (2015-2017)
Research
Cellular architecture Sociology of biomolecules within cells In situ structural biology
Structure and topography of the synaptic V-ATPase–synaptophysin complex, Wang, C.*, Jiang, W.*, Leitz, J.*, Yang, K., Esquivies, L., Wang, X., Shen, X., Held, R., Adams, D.J., Basta, T., Hampton, L., Jian, R., Jiang, L., Stowell, M.H.B., Baumeister, W., Guo, Q.#, Brunger, A.T.#, 2024
Vimentin regulates nuclear segmentation in neutrophils, Liu, J.*, Li, Z.*, Li, M.*, Du, W., Baumeister, W., Yang, J.#, and Guo, Q.#, 2023
A practical multicellular sample preparation pipeline broadens the application of in situ cryo-electron tomography, Wu, Y.*, Qin, C.*, Du, W.*, Guo, Z., Chen, L., Guo, Q.#, 2023
Cryo-Electron Tomography of Toxoplasma gondii Indicates That the Conoid Fiber May Be Derived from Microtubules, Li, Z., Du, W., Yang, J., Lai, D.-H., Lun, Z.-R., Guo, Q.#, 2023
The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system, Saha, I., Yuste-Checa, P., Da Silva Padilha, M., Guo, Q., Körner, R., Holthusen, H., Trinkaus, V.A., Dudanova, I., Fernández-Busnadiego, R., Baumeister, W., Sanders, D.W., Gautam, S., Diamond, M.I., Hartl, F.U.#, Hipp, M.S.#, 2023
Integrated multimodality microscope for accurate and efficient target-guided cryo-lamellae preparation, Li, W.*, Lu, J.*, Xiao, K.*, Zhou, M.*, Li, Y., Zhang, X., Li, Z., Gu, L., Xu, X., Guo, Q.#, Xu, T.#, Ji, W.#, 2023
A transformation clustering algorithm and its application in polyribosomes structural profiling, Jiang, W., Wagner, J., Du, W., Plitzko, J., Baumeister, W., Beck, F.#, and Guo, Q.#, 2022
Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons, Riemenschneider, H.*, Guo, Q.*, Bader, J., Frottin, F., Farny, D., Kleinberger, G., Haass, C., Mann, M., Hartl, F.U., Baumeister, W. et al., 2022
A feature-guided, focused 3D signal permutation method for subtomogram averaging, Peters, J.J., Leitz, J., Guo, Q., Beck, F., Baumeister, W. and Brunger, A.T., 2022
Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex, Huang, B.*, Guo, Q.*, Niedermeier, M.L., Cheng, J., Engler, T., Maurer, M., Pautsch, A., Baumeister, W., Stengel, F., Kochanek, S., et al., 2021
In situ architecture of neuronal α-Synuclein inclusions, Trinkaus, V.A., Riera-Tur, I., Martínez-Sánchez, A., Bäuerlein, F.J.B., Guo, Q., Arzberger, T., Baumeister, W., Dudanova, I., Hipp, M.S., Hartl, F.U., et al., 2021
The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin, Seefelder, M., Alva, V., Huang, B., Engler, T., Baumeister, W., Guo, Q., Fernandez-Busnadiego, R., Lupas, A.N., and Kochanek, S., 2020
Stress- and ubiquitylation-dependent phase separation of the proteasome, Yasuda, S., Tsuchiya, H., Kaiho, A., Guo, Q., Ikeuchi, K., Endo, A., Arai, N., Ohtake, F., Murata, S., Inada, T., et al., 2020
The cryo-electron microscopy structure of huntingtin, Guo, Q.*, Bin, H.*, Cheng, J., Seefelder, M., Engler, T., Pfeifer, G., Oeckl, P., Otto, M., Moser, F., Maurer, M., Pautsch, A., Baumeister, W.#, Fernandez-Busnadiego, R.#, Kochanek, S.#, 2018
An integration of fast alignment and maximum-likelihood methods for electron subtomogram averaging and classification, Zhao, Y., Zeng, X., Guo, Q., and Xu, M., 2018
Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii, Li, Z., Guo, Q., Zheng, L., Ji, Y., Xie, Y.T., Lai, D.H., Lun, Z.R., Suo, X., and Gao, N., 2017
CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane, Mi, N., Chen, Y., Wang, S., Chen, M., Zhao, M., Yang, G., Ma, M., Su, Q., Luo, S., Shi, J., Xu, J., Guo, Q., et al., 2015
Structural and Functional Insights into the Mode of Action of a Universally Conserved Obg GTPase, Feng, B., Mandava, CS., Guo, Q., Wang, J., Cao, W., et al., 2014
Characterization of the in vivo 30S ribosomal assembly intermediates reveals essential role of S5 and location of unprocessed ends of the 17S rRNA, Yang, Z.*, Guo, Q.*, Goto, S., Chen, Y., Li, N., Muto, A., Himeno, H., Deng, H., Lei, J.#, and Gao, N.#, 2014
Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit, Li, N., Chen, Y., Guo, Q., Zhang, Y., Yuan, Y., Ma, C., Deng, H., Lei, J.#, and Gao, N.#, 2013
Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process, Guo, Q.*, Goto, S.*, Chen, Y.*, Feng, B., Xu, Y., Muto, A., Himeno, H., Deng, H., Lei, J., and Gao, N., 2013
Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein, Huang, W.*, Choi, W.*, Hu, W., Mi, N., Guo, Q., Ma, M., Liu, M., Tian, Y., Lu, P., Wang, F.L., et al., 2012
Structural basis for the function of a small GTPase RsgA on the 30S ribosomal subunit maturation revealed by cryoelectron microscopy, Guo, Q.*, Yuan, Y.*, Xu, Y.*, Feng, B., Liu, L., Chen, K., Sun, M., Yang, Z., Lei, J.#, and Gao, N.#, 2011
