Professor | Yao Cong | Asia Growth Partners

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Name	Yao Cong
Contact Information	cong@sibcb.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Yao Cong

Contact Information

cong@sibcb.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1995-09 to 2000-07 PhD: Jilin University 1991-09 to 1995-07 Bachelor's: Liaoning Normal University
Work Experience	2011-07 to Present - Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences - Researcher 2010-10 to 2011-06 - National Center for Macromolecular Imaging, Baylor College of Medicine, USA - Lecturer 2005-06 to 2010-09 - National Center for Macromolecular Imaging, Baylor College of Medicine, USA - Assistant Researcher 2003-05 to 2005-05 - University of Texas Health Science Center at Houston, USA - Postdoctoral Researcher 2001-11 to 2003-04 - Scripps Research Institute, USA - Postdoctoral Researcher
Awards	Shanghai Biophysics Society Outstanding Young Female Scientist (2015): City Level National Science Foundation for Outstanding Youth (2012): National Level Chinese Academy of Sciences '****' (2012): Institute Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1995-09 to 2000-07 PhD: Jilin University
1991-09 to 1995-07 Bachelor's: Liaoning Normal University

Work Experience

2011-07 to Present - Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences - Researcher
2010-10 to 2011-06 - National Center for Macromolecular Imaging, Baylor College of Medicine, USA - Lecturer
2005-06 to 2010-09 - National Center for Macromolecular Imaging, Baylor College of Medicine, USA - Assistant Researcher
2003-05 to 2005-05 - University of Texas Health Science Center at Houston, USA - Postdoctoral Researcher
2001-11 to 2003-04 - Scripps Research Institute, USA - Postdoctoral Researcher

Awards

Shanghai Biophysics Society Outstanding Young Female Scientist (2015): City Level
National Science Foundation for Outstanding Youth (2012): National Level
Chinese Academy of Sciences '****' (2012): Institute Level

Areas of Focus	Protein Folding and Unfolding Mechanisms Assisted by Molecular Chaperones Development of Image Alignment Methods and Flexible Fitting Tools for Cryo-EM Data Processing
Publications	Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections, Zhang C, Xu C, Dai W, Wang Y, Liu Z, Zhang X, Wang X, Wang H, Gong S, Cong Y, Huang Z, 2021 Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ, Chen J, Wang Y, Xu C, Chen K, Zhao Q, Wang S, Yin Y, Peng C, Ding Z, Cong Y, 2021 Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM, Zheng W, Li F, Ding Z, Liu H, Zhu L, Xu C, Li J, Gao Q, Wang Y, Fu Z, Peng C, Yan X, Zhu X, Cong Y, 2021 Development and structural basis of a two-Mab cocktail for treating SARS-CoV-2 infections, Zhang C, Wang YF, Zhu Y, Liu C, Gu C, Xu S, Wang YL, Zhou Y, Wang YX, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z, 2021 Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM, Xu C, Wang YX, Liu C, Zhang C, Han W, Hong X, Wang YF, Hong Q, Wang S, Zhao Q, Wang YL, Yang Y, Chen K, Zheng W, Kong L, Wang F, Zuo Q, Huang Z, Cong Y, 2021 TRiC/CCT Chaperonin: Structure and Function, Jin M, Liu C, Han W, Cong Y, 2020 A complex structure of arrestin-2 bound to a G protein-coupled receptor, Yin W, Li Z, Jin M, Yin YL, Waal PW, Pal K, Yin Y, Gao X, He Y, Gao J, Wang X, Zhang Y, Zhou H, Melcher K, Jiang Y, Cong Y, Zhou XE, Yu X, Xu HE, 2019 An ensemble of cryo-EM structures of TRiC reveals its conformational landscape and subunit specificity, Jin M, Han W, Liu C, Zang Y, Li J, Wang F, Wang Y, Cong Y, 2019 Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations, Ding Z, Xu C, Sahu I, Wang Y, Fu Z, Huang M, Wong CCL, Glickman MH, and Cong Y, 2019 Coxsackievirus A10 atomic structure facilitating the discovery of a broadspectrum inhibitor against human enteroviruses, Chen J, Ye X, Zhang X, Zhu Z, Zhang X, Xu Z, Ding Z, Zou G, Liu Q, Kong L, Jiang W, Zhu W, Cong Y and Huang Z, 2019 Architecture and subunit arrangement of the complete Saccharomyces cerevisiae COMPASS complex, Wang Y, Ding Z, Liu X, Bao Y, Huang M, Wong CCL, Hong X, Cong Y, 2018 Yeast inner-subunit PA–NZ-1 labeling strategy for accurate subunit identification in a macromolecular complex through cryo-EM analysis, Wang H, Han W, Takagi J, Cong Y, 2018 Development of a yeast internal-subunit eGFP labeling strategy and its application in subunit identification in eukaryotic group II chaperonin TRiC/CCT, Zang Y, Wang H, Cui Z, Jin M, Liu C, Han W, Wang YX, Cong Y, 2018 A 3.0-Angstrom Resolution Cryo-Electron Microscopy Structure and Antigenic Sites of Coxsackievirus A6-Like Particles, Chen J, Zhang C, Zhou Y, Zhang X, Shen C, Ye X, Jiang W, Huang Z and Cong Y, 2018 Structure, Immunogenicity and Protective Mechanism of an Engineered Enterovirus 71-Like Particle Vaccine Mimicking 80S Empty Capsid, Wang X, Ku Z, Zhang X, Ye X, Chen J, Liu Q, Zhang W, Zhang C, Fu Z, Jin X, Cong Y and Huang Z, 2018 Identification of an allosteric network that influences assembly and function of group II chaperonins, Jin M, Cong Y, 2017 Beta-propiolactone inactivation of coxsackievirus A16 induces structural alteration and surface modification of viral capsids, Fan C, Ye X, Ku Z, Kong L, Liu Q, Xu C, Cong Y, Huang Z, 2017 High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx, Ding Z, Fu Z, Xu C, Wang YF, Wang YX, Li J, Kong L, Chen J, Li N, Zhang R, Cong Y, 2017 Staggered ATP binding mechanism of eukaryotic chaperonin TRiC(CCT) revealed through high-resolution cryo-EM, Zang Y, Jin M, Wang H, Cui Z, Liu C, Han W, Wang YX, Cong Y, 2016 Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca2+/H+ antiporter, Shao J, Fu Z, Ji Y, Guan X, Guo S, Ding Z, Yang X, Cong Y, Shen Y, 2016 Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody, Ye X, Fan C, Ku Z, Zuo T, Kong L, Zhang C, Shi J, Liu Q, Chen T, Zhang Y, Jiang W, Zhang L, Huang Z, Cong Y, 2016 Architecture of the mitochondrial calcium uniporter, Oxenoid K, Dong Y, Cao C, Cui T, Sancak Y, Markhard AL, Grabarek Z, Kong L, Liu Z, Ouyang B, Cong Y, Mootha VK, Chou JJ, 2016 Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5, Jin W, Wang Y, Liu CP, Yang N, Jin M, Cong Y, Wang M, Xu RM, 2016 Crystallization scale purification of a7 nicotinic acetylcholine receptor from mammalian cells using a BacMam expression system, Cheng H, Fan C, Zhang S, Wu Z, Cui Z, Melcher K, Zhang C, Jiang Y, Cong Y, Xu HE, 2015 High yield and efficient expression and purification of the human 5-HT3A receptor, Wu Z, Cui Z, Cheng H, Fan C, Melcher K, Jiang Y, Zhang C, Jiang H, Cong Y, Liu Q, Xu HE, 2015 Structural Insight into Autoinhibition and Histone H3-induced Activation of DNMT3A, Guo X, Wang L, Li J, Ding Z, Xiao J, Yin X, He S, Shi P, Dong L, Li G, Tian C, Wang J, Cong Y, Xu Y, 2015 Chimeric virus-like particle vaccines displaying conserved enterovirus 71 epitopes elicit protective neutralizing antibodies in mice through divergent mechanisms, Ye X, Ku Z, Liu Q, Wang X, Shi J, Zhang Y, Kong L, Cong Y, Huang Z, 2014 TRiC’s tricks inhibit huntingtin aggregation, Shahmoradian SH, Galaz-Montoya JG, Schmid MF, Cong Y, Ma B, Spiess C, Frydman J, Ludtke SJ, Chiu W, 2013 Cryo-EM Structure of a Molluscan Hemocyanin Suggests Its Allosteric Mechanism, Zhang Q, Dai X, Cong Y, Zhang J, Chen DH, Dougherty MT, Wang J, Ludtke SJ, Schmid MF, Chiu W, 2013 Structural and biochemical studies of RIG-I antiviral signaling, Feng M, Ding Z, Xu L, Kong L, Wang W, Jiao S, Shi Z, Greene MI, Cong Y, Zhou Z, 2013 The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT, Leitner A, Joachimiak LA, Bracher A, Mönkemeyer L, Walztho

Areas of Focus

Protein Folding and Unfolding Mechanisms Assisted by Molecular Chaperones
Development of Image Alignment Methods and Flexible Fitting Tools for Cryo-EM Data Processing

Publications

Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections, Zhang C, Xu C, Dai W, Wang Y, Liu Z, Zhang X, Wang X, Wang H, Gong S, Cong Y, Huang Z, 2021
Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ, Chen J, Wang Y, Xu C, Chen K, Zhao Q, Wang S, Yin Y, Peng C, Ding Z, Cong Y, 2021
Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM, Zheng W, Li F, Ding Z, Liu H, Zhu L, Xu C, Li J, Gao Q, Wang Y, Fu Z, Peng C, Yan X, Zhu X, Cong Y, 2021
Development and structural basis of a two-Mab cocktail for treating SARS-CoV-2 infections, Zhang C, Wang YF, Zhu Y, Liu C, Gu C, Xu S, Wang YL, Zhou Y, Wang YX, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z, 2021
Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM, Xu C, Wang YX, Liu C, Zhang C, Han W, Hong X, Wang YF, Hong Q, Wang S, Zhao Q, Wang YL, Yang Y, Chen K, Zheng W, Kong L, Wang F, Zuo Q, Huang Z, Cong Y, 2021
TRiC/CCT Chaperonin: Structure and Function, Jin M, Liu C, Han W, Cong Y, 2020
A complex structure of arrestin-2 bound to a G protein-coupled receptor, Yin W, Li Z, Jin M, Yin YL, Waal PW, Pal K, Yin Y, Gao X, He Y, Gao J, Wang X, Zhang Y, Zhou H, Melcher K, Jiang Y, Cong Y, Zhou XE, Yu X, Xu HE, 2019
An ensemble of cryo-EM structures of TRiC reveals its conformational landscape and subunit specificity, Jin M, Han W, Liu C, Zang Y, Li J, Wang F, Wang Y, Cong Y, 2019
Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations, Ding Z, Xu C, Sahu I, Wang Y, Fu Z, Huang M, Wong CCL, Glickman MH, and Cong Y, 2019
Coxsackievirus A10 atomic structure facilitating the discovery of a broadspectrum inhibitor against human enteroviruses, Chen J, Ye X, Zhang X, Zhu Z, Zhang X, Xu Z, Ding Z, Zou G, Liu Q, Kong L, Jiang W, Zhu W, Cong Y and Huang Z, 2019
Architecture and subunit arrangement of the complete Saccharomyces cerevisiae COMPASS complex, Wang Y, Ding Z, Liu X, Bao Y, Huang M, Wong CCL, Hong X, Cong Y, 2018
Yeast inner-subunit PA–NZ-1 labeling strategy for accurate subunit identification in a macromolecular complex through cryo-EM analysis, Wang H, Han W, Takagi J, Cong Y, 2018
Development of a yeast internal-subunit eGFP labeling strategy and its application in subunit identification in eukaryotic group II chaperonin TRiC/CCT, Zang Y, Wang H, Cui Z, Jin M, Liu C, Han W, Wang YX, Cong Y, 2018
A 3.0-Angstrom Resolution Cryo-Electron Microscopy Structure and Antigenic Sites of Coxsackievirus A6-Like Particles, Chen J, Zhang C, Zhou Y, Zhang X, Shen C, Ye X, Jiang W, Huang Z and Cong Y, 2018
Structure, Immunogenicity and Protective Mechanism of an Engineered Enterovirus 71-Like Particle Vaccine Mimicking 80S Empty Capsid, Wang X, Ku Z, Zhang X, Ye X, Chen J, Liu Q, Zhang W, Zhang C, Fu Z, Jin X, Cong Y and Huang Z, 2018
Identification of an allosteric network that influences assembly and function of group II chaperonins, Jin M, Cong Y, 2017
Beta-propiolactone inactivation of coxsackievirus A16 induces structural alteration and surface modification of viral capsids, Fan C, Ye X, Ku Z, Kong L, Liu Q, Xu C, Cong Y, Huang Z, 2017
High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx, Ding Z, Fu Z, Xu C, Wang YF, Wang YX, Li J, Kong L, Chen J, Li N, Zhang R, Cong Y, 2017
Staggered ATP binding mechanism of eukaryotic chaperonin TRiC(CCT) revealed through high-resolution cryo-EM, Zang Y, Jin M, Wang H, Cui Z, Liu C, Han W, Wang YX, Cong Y, 2016
Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca2+/H+ antiporter, Shao J, Fu Z, Ji Y, Guan X, Guo S, Ding Z, Yang X, Cong Y, Shen Y, 2016
Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody, Ye X, Fan C, Ku Z, Zuo T, Kong L, Zhang C, Shi J, Liu Q, Chen T, Zhang Y, Jiang W, Zhang L, Huang Z, Cong Y, 2016
Architecture of the mitochondrial calcium uniporter, Oxenoid K, Dong Y, Cao C, Cui T, Sancak Y, Markhard AL, Grabarek Z, Kong L, Liu Z, Ouyang B, Cong Y, Mootha VK, Chou JJ, 2016
Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5, Jin W, Wang Y, Liu CP, Yang N, Jin M, Cong Y, Wang M, Xu RM, 2016
Crystallization scale purification of a7 nicotinic acetylcholine receptor from mammalian cells using a BacMam expression system, Cheng H, Fan C, Zhang S, Wu Z, Cui Z, Melcher K, Zhang C, Jiang Y, Cong Y, Xu HE, 2015
High yield and efficient expression and purification of the human 5-HT3A receptor, Wu Z, Cui Z, Cheng H, Fan C, Melcher K, Jiang Y, Zhang C, Jiang H, Cong Y, Liu Q, Xu HE, 2015
Structural Insight into Autoinhibition and Histone H3-induced Activation of DNMT3A, Guo X, Wang L, Li J, Ding Z, Xiao J, Yin X, He S, Shi P, Dong L, Li G, Tian C, Wang J, Cong Y, Xu Y, 2015
Chimeric virus-like particle vaccines displaying conserved enterovirus 71 epitopes elicit protective neutralizing antibodies in mice through divergent mechanisms, Ye X, Ku Z, Liu Q, Wang X, Shi J, Zhang Y, Kong L, Cong Y, Huang Z, 2014
TRiC’s tricks inhibit huntingtin aggregation, Shahmoradian SH, Galaz-Montoya JG, Schmid MF, Cong Y, Ma B, Spiess C, Frydman J, Ludtke SJ, Chiu W, 2013
Cryo-EM Structure of a Molluscan Hemocyanin Suggests Its Allosteric Mechanism, Zhang Q, Dai X, Cong Y, Zhang J, Chen DH, Dougherty MT, Wang J, Ludtke SJ, Schmid MF, Chiu W, 2013
Structural and biochemical studies of RIG-I antiviral signaling, Feng M, Ding Z, Xu L, Kong L, Wang W, Jiao S, Shi Z, Greene MI, Cong Y, Zhou Z, 2013
The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT, Leitner A, Joachimiak LA, Bracher A, Mönkemeyer L, Walztho

Protein Folding Molecular Chaperones Cryo-Em Single Particle Reconstruction Electron Tomography Bioinformatics Molecular Flexibility Cancer Neurodegenerative Diseases Tric/Cct

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Zhiwei Cao - Tongji University

Xiongwen Cao - East China Normal University

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