Professor | Chengsen Cui | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Chengsen Cui
Contact Information	cuichs@tib.cas.cn
Language ability	English, Chinese
Province	Tianjin

Upload Avatar (500 x 500)

Name

Chengsen Cui

Contact Information

cuichs@tib.cas.cn

Language ability

English, Chinese

Province

Tianjin

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2011-09--2015-08 PhD: University of Bristol 2007-07--2011-07 Bachelor's Degree: Northwest A&F University
Work Experience	2018-09~2021-08 - Purdue University - Postdoctoral Researcher 2017-08~2018-09 - Harvard University - Postdoctoral Researcher 2015-08~2017-08 - Hong Kong University of Science and Technology - Assistant Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2011-09--2015-08 PhD: University of Bristol
2007-07--2011-07 Bachelor's Degree: Northwest A&F University

Work Experience

2018-09~2021-08 - Purdue University - Postdoctoral Researcher
2017-08~2018-09 - Harvard University - Postdoctoral Researcher
2015-08~2017-08 - Hong Kong University of Science and Technology - Assistant Researcher

Areas of Focus	Directed Evolution of Proteins and Design of New Reactions Design and Application of Chemical-Enzymatic Cross-Synthesis Systems Exploration of Biomimetic Semi-Synthetic Routes for Natural Products and Chiral Drug Molecules
Publications	An unexpected role of EasD af: catalyzing the conversion of chanoclavine aldehyde to chanoclavine acid, ZhiPu Yu, Chunyan An, Yongpeng Yao, JuZhang Yan, ShuShan Gao, YuCheng Gu, ChangYun Wang, Chengsen Cui, 2024 Chemoenzymatic Synthesis of Selegiline: An Imine Reductase-Catalyzed Approach, Hu, Yuliang, Bao, Jinping, Tang, Dongyu, Shushan Gao, Wang, Fei, Ding, Zhongtao, Cui, Chengsen, 2024 Chemoenzymatic total synthesis of rotigotine via IRED-catalyzed reductive amination, Tang, Dongyu, Ma, Yaqing, Bao, Jinping, Shushan Gao, man shuli, Cui, Chengsen, 2024 Peroxygenase-Enabled Reductive Kinetic Resolution for the Enantioenrichment of Organoperoxides, Shen, qianqian, Yan, Juzhang, Han, Yuchen, Zhang, Zaoxiao, Li, Huanhuan, Kong, Dulin, shi, jianjun, Cui, Chengsen, Zhang, Wuyuan, 2024 Vanadium-containing chloroperoxidase-catalyzed versatile valorization of phenols and phenolic acids, Li, Huanhuan, duan, peigao, Huang, Yawen, Chengsen Cui, Frank Hollmann, Yunjian Ma, Wang, Yonghua, Zhang, Jie, Liu, Weidong, Zhang, Wuyuan, 2024 Semi-rational design of an imine reductase for asymmetric synthesis of alkylated S-4-azepanamines, Fang, Zhuzhu, Zhang, Jun, Ma, Yaqing, Yang, Lujia, Gao, Qiang, Shushan Gao, Cui, Chengsen, 2023 Structure-guided semi-rational design of an imine reductase for enantio-complementary synthesis of pyrrolidinamine, Zhang, Jun, Ma, Yaqing, Zhu, Fangfang, Bao, Jinping, Wu, Qiaqing, Gao, ShuShan, Cui, Chengsen, 2023 Total Synthesis of UCS1025A via Tandem Carbonylative Stille Cross Coupling and Diels-Alder Reaction, Cui, Chengsen, Dai, Mingji, 2023 Actinomycetes-derived imine reductases with a preference towards bulky amine substrates, Zhang, Jun, Li, Xin, Chen, Rongchang, Tan, Xianwei, Liu, Xiongduo, Ma, Yaqing, Zhu, Fangfang, An, Chunyan, Wei, Guangzheng, Yao, Yongpeng, Yang, Lujia, Zhang, Peng, Wu, Qiaqing, Sun, Zhoutong, Wang, BinGui, Gao, ShuShan, Cui, Chengsen, 2022 Chemoenzymatic Hunsdiecker-Type Decarboxylative Bromination of Cinnamic Acids, Li, Huanhuan, Younes, Sabry H H, Chen, Shaohang, Duan, Peigao, Cui, Chengsen, Wever, Ron, Zhang, Wuyuan, Hollmann, Frank, 2022 Tuning an Imine Reductase for the Asymmetric Synthesis of Azacycloalkylamines by Concise Structure-Guided Engineering, Zhang, Jun, Liao, Daohong, Chen, Rongchang, Zhu, Fangfang, Ma, Yaqing, Gao, Lei, Qu, Ge, Cui, Chengsen, Sun, Zhoutong, Lei, Xiaoguang, Gao, ShuShan, 2022 Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles, Jun-Kuan Li, Ge Qu, Xu Li, Yuchen Tian, Chengsen Cui, Fa-Guang Zhang, Wuyuan Zhang, Jun-An Ma, Manfred T. Reetz, Zhoutong Sun, 2022 A hybrid system for the overproduction of complex ergot alkaloid chanoclavine, Ma, Yaqing, Yan, Juzhang, Yang, Lujia, Yao, Yongpeng, Wang, Luoyi, Gao, ShuShan, Cui, Chengsen, 2022 A combined strategy for the overproduction of complex ergot alkaloid agroclavine, Yu Zhipu, An Chunyan, Yao Yongpeng, Wang Changyun, Sun Zhoutong, Cui Chengsen, Liu Ling, Gao Shushan, 2022 Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity, Raffa, Nicholas, Won, Tae Hyung, Sukowaty, Andrew, Candor, Kathleen, Cui, Chengsen, Halder, Saayak, Dai, Mingji, LanderoFigueroa, Julio A, Schroeder, Frank C, Keller, Nancy P, 2021 Flow Chemistry-Enabled Divergent and Enantioselective Total Syntheses of Massarinolin A, Purpurolides B, D, E, 2,3-Deoxypurpurolide C, and Structural Revision of Massarinolin A, Wang, YeCheng, Cui, Chengsen, Dai, Mingji, 2021 Total Synthesis and Target Identification of the Curcusone Diterpenes, Cui, Chengsen, Dwyer, Brendan G, Liu, Chang, Abegg, Daniel, Cai, ZhongJian, Hoch, Dominic G, Yin, Xianglin, Qiu, Nan, Liu, JieQing, Adibekian, Alexander, Dai, Mingji, 2021 Total Synthesis of Laingolide B Stereoisomers and Assignment of Absolute Configuration, Cui, Chengsen, Dai, WeiMin, 2018 Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics, Thistlethwaite, Iain R G, Bull, Freya M, Cui, Chengsen, Walker, Paul D, Gao, ShuShan, Wang, Luoyi, Song, Zhongshu, Masschelein, Joleen, Lavigne, Rob, Crump, Matthew P, Race, Paul R, Simpson, Thomas J, Willis, Christine L, 2017 Microwave-Assisted Intramolecular Ullmann Diaryl Etherification as the Post-Ugi Annulation for Generation of Dibenzb,f1,4oxazepine Scaffold, Shi, Jianyu, Wu, Jinlong, Cui, Chengsen, Dai, WeiMin, 2016 THE COMPLETION OF ESTERIFICATION OF FREE FATTY ACIDS IN ZANTHOXYLUM BUNGEANUM SEED OIL WITH ETHANOL, Zhang, Junhua, Cui, Chengsen, Chen, Haidong, Liu, Jianjun, 2014

Areas of Focus

Directed Evolution of Proteins and Design of New Reactions
Design and Application of Chemical-Enzymatic Cross-Synthesis Systems
Exploration of Biomimetic Semi-Synthetic Routes for Natural Products and Chiral Drug Molecules

Publications

An unexpected role of EasD af: catalyzing the conversion of chanoclavine aldehyde to chanoclavine acid, ZhiPu Yu, Chunyan An, Yongpeng Yao, JuZhang Yan, ShuShan Gao, YuCheng Gu, ChangYun Wang, Chengsen Cui, 2024
Chemoenzymatic Synthesis of Selegiline: An Imine Reductase-Catalyzed Approach, Hu, Yuliang, Bao, Jinping, Tang, Dongyu, Shushan Gao, Wang, Fei, Ding, Zhongtao, Cui, Chengsen, 2024
Chemoenzymatic total synthesis of rotigotine via IRED-catalyzed reductive amination, Tang, Dongyu, Ma, Yaqing, Bao, Jinping, Shushan Gao, man shuli, Cui, Chengsen, 2024
Peroxygenase-Enabled Reductive Kinetic Resolution for the Enantioenrichment of Organoperoxides, Shen, qianqian, Yan, Juzhang, Han, Yuchen, Zhang, Zaoxiao, Li, Huanhuan, Kong, Dulin, shi, jianjun, Cui, Chengsen, Zhang, Wuyuan, 2024
Vanadium-containing chloroperoxidase-catalyzed versatile valorization of phenols and phenolic acids, Li, Huanhuan, duan, peigao, Huang, Yawen, Chengsen Cui, Frank Hollmann, Yunjian Ma, Wang, Yonghua, Zhang, Jie, Liu, Weidong, Zhang, Wuyuan, 2024
Semi-rational design of an imine reductase for asymmetric synthesis of alkylated S-4-azepanamines, Fang, Zhuzhu, Zhang, Jun, Ma, Yaqing, Yang, Lujia, Gao, Qiang, Shushan Gao, Cui, Chengsen, 2023
Structure-guided semi-rational design of an imine reductase for enantio-complementary synthesis of pyrrolidinamine, Zhang, Jun, Ma, Yaqing, Zhu, Fangfang, Bao, Jinping, Wu, Qiaqing, Gao, ShuShan, Cui, Chengsen, 2023
Total Synthesis of UCS1025A via Tandem Carbonylative Stille Cross Coupling and Diels-Alder Reaction, Cui, Chengsen, Dai, Mingji, 2023
Actinomycetes-derived imine reductases with a preference towards bulky amine substrates, Zhang, Jun, Li, Xin, Chen, Rongchang, Tan, Xianwei, Liu, Xiongduo, Ma, Yaqing, Zhu, Fangfang, An, Chunyan, Wei, Guangzheng, Yao, Yongpeng, Yang, Lujia, Zhang, Peng, Wu, Qiaqing, Sun, Zhoutong, Wang, BinGui, Gao, ShuShan, Cui, Chengsen, 2022
Chemoenzymatic Hunsdiecker-Type Decarboxylative Bromination of Cinnamic Acids, Li, Huanhuan, Younes, Sabry H H, Chen, Shaohang, Duan, Peigao, Cui, Chengsen, Wever, Ron, Zhang, Wuyuan, Hollmann, Frank, 2022
Tuning an Imine Reductase for the Asymmetric Synthesis of Azacycloalkylamines by Concise Structure-Guided Engineering, Zhang, Jun, Liao, Daohong, Chen, Rongchang, Zhu, Fangfang, Ma, Yaqing, Gao, Lei, Qu, Ge, Cui, Chengsen, Sun, Zhoutong, Lei, Xiaoguang, Gao, ShuShan, 2022
Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles, Jun-Kuan Li, Ge Qu, Xu Li, Yuchen Tian, Chengsen Cui, Fa-Guang Zhang, Wuyuan Zhang, Jun-An Ma, Manfred T. Reetz, Zhoutong Sun, 2022
A hybrid system for the overproduction of complex ergot alkaloid chanoclavine, Ma, Yaqing, Yan, Juzhang, Yang, Lujia, Yao, Yongpeng, Wang, Luoyi, Gao, ShuShan, Cui, Chengsen, 2022
A combined strategy for the overproduction of complex ergot alkaloid agroclavine, Yu Zhipu, An Chunyan, Yao Yongpeng, Wang Changyun, Sun Zhoutong, Cui Chengsen, Liu Ling, Gao Shushan, 2022
Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity, Raffa, Nicholas, Won, Tae Hyung, Sukowaty, Andrew, Candor, Kathleen, Cui, Chengsen, Halder, Saayak, Dai, Mingji, LanderoFigueroa, Julio A, Schroeder, Frank C, Keller, Nancy P, 2021
Flow Chemistry-Enabled Divergent and Enantioselective Total Syntheses of Massarinolin A, Purpurolides B, D, E, 2,3-Deoxypurpurolide C, and Structural Revision of Massarinolin A, Wang, YeCheng, Cui, Chengsen, Dai, Mingji, 2021
Total Synthesis and Target Identification of the Curcusone Diterpenes, Cui, Chengsen, Dwyer, Brendan G, Liu, Chang, Abegg, Daniel, Cai, ZhongJian, Hoch, Dominic G, Yin, Xianglin, Qiu, Nan, Liu, JieQing, Adibekian, Alexander, Dai, Mingji, 2021
Total Synthesis of Laingolide B Stereoisomers and Assignment of Absolute Configuration, Cui, Chengsen, Dai, WeiMin, 2018
Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics, Thistlethwaite, Iain R G, Bull, Freya M, Cui, Chengsen, Walker, Paul D, Gao, ShuShan, Wang, Luoyi, Song, Zhongshu, Masschelein, Joleen, Lavigne, Rob, Crump, Matthew P, Race, Paul R, Simpson, Thomas J, Willis, Christine L, 2017
Microwave-Assisted Intramolecular Ullmann Diaryl Etherification as the Post-Ugi Annulation for Generation of Dibenzb,f1,4oxazepine Scaffold, Shi, Jianyu, Wu, Jinlong, Cui, Chengsen, Dai, WeiMin, 2016
THE COMPLETION OF ESTERIFICATION OF FREE FATTY ACIDS IN ZANTHOXYLUM BUNGEANUM SEED OIL WITH ETHANOL, Zhang, Junhua, Cui, Chengsen, Chen, Haidong, Liu, Jianjun, 2014

Directed Evolution Protein Engineering Enzyme Catalysis New Reactions Chemical Synthesis Enzymatic Synthesis Natural Products Chiral Drugs Biomimetic Synthesis Sustainable Chemistry

Yanfang Wang - Tongji University

Xudong Qu - Shanghai Jiao Tong University

Xudong Qu - Shanghai Jiao Tong University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us