Professor | Xudong Qu | Asia Growth Partners

Name	Xudong Qu
Contact Information	quxd19@sjtu.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Xudong Qu

Contact Information

quxd19@sjtu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Shanghai Jiao Tong University
Faculty	Life Sciences
Academic Background & Achievements	2002-2007 PhD: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 1998-2002 Bachelor: Department of Chemistry, East China Normal University
Work Experience	2020.09-present: Professor, School of Life Sciences and Technology / Zhangjiang Advanced Research Institute, Shanghai Jiao Tong University 2012.01-2020.08: Professor, School of Pharmacy, Wuhan University 2011.01-2011.12: Associate Research Fellow, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 2008.11-2010.12: Assistant Research Fellow, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 2007.09-2008.10: Postdoctoral Fellow, Department of Chemistry, Massachusetts Institute of Technology, USA
Awards	2023: Gold Innovation Project Award, National Technical Standards Innovation Base (Dairy) 2023: Leader of Outstanding Young Team, Central Universities 2023: Bronze Award, 9th China International Internet Plus College Students Innovation and Entrepreneurship Competition (Shanghai Area, as mentor) 2022: Shanghai Outstanding Academic Leader 2013: National Natural Science Foundation of China, Outstanding Young Scientist Fund 2012: Ministry of Education New Century Excellent Talents Support Plan 2012: Luojia Distinguished Professor, Wuhan University

University/Lab Affiliation and Title

Shanghai Jiao Tong University

Faculty

Life Sciences

Academic Background & Achievements

2002-2007 PhD: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
1998-2002 Bachelor: Department of Chemistry, East China Normal University

Work Experience

2020.09-present: Professor, School of Life Sciences and Technology / Zhangjiang Advanced Research Institute, Shanghai Jiao Tong University
2012.01-2020.08: Professor, School of Pharmacy, Wuhan University
2011.01-2011.12: Associate Research Fellow, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
2008.11-2010.12: Assistant Research Fellow, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
2007.09-2008.10: Postdoctoral Fellow, Department of Chemistry, Massachusetts Institute of Technology, USA

Awards

2023: Gold Innovation Project Award, National Technical Standards Innovation Base (Dairy)
2023: Leader of Outstanding Young Team, Central Universities
2023: Bronze Award, 9th China International Internet Plus College Students Innovation and Entrepreneurship Competition (Shanghai Area, as mentor)
2022: Shanghai Outstanding Academic Leader
2013: National Natural Science Foundation of China, Outstanding Young Scientist Fund
2012: Ministry of Education New Century Excellent Talents Support Plan
2012: Luojia Distinguished Professor, Wuhan University

Areas of Focus	Directed biosynthesis of natural products
Publications	An unusual aromatase/cyclase programs the formation of the phenyldimethylanthrone framework in anthrabenzoxocinones and fasamycin., Kai Jiang, Xu Chen, Xiaoli Yan, Zixin Deng, Shunkun Luo, Xudong Qu, 2024 Engineering the substrate specificity of a P450 dimerase enables the collective biosynthesis of heterodimeric tryptophan-containing diketopiperazines., Chenghai Sun, Bao-Di Ma, Guangjun Li, Wenya Tian, Lu Yang, Haidong Peng, Zhi Lin, Zixin Deng, Xu-Dong Kong, Xudong Qu, 2023 A large conserved family of small-molecule carboxyl methyltransferases identified from microorganisms., Zhi Lin, Zhiwei Hu, Linjun Zhou, Benben Liu, Xiaowei Huang, Zixin Deng, Xudong Qu, 2023 A chemoenzymatic approach to C14-functionalized steroids., Fuzheng Song, Mengmeng Zheng, Junlin Wang, Huanhuan Liu, Zhi Lin, Bengbeng Liu, Zixin Deng, Qianghui Zhou, Xudong Qu, 2023 A pair of atypical KAS III homologues with initiation and elongation functions programs the polyketide biosynthesis in asukamycin., Xiaoli Yan, Jun Zhang, Hongqun Tan, Zhihao Liu, Kai Jiang, Wenya Tian, Mengmeng Zheng, Zhi Lin, Zixin Deng, Xudong Qu, 2022 An atypical acyl-CoA synthetase enables efficient biosynthesis of extender units for engineering a polyketide carbon scaffold., Mengmeng Zheng, Jun Zhang, Wan Zhang, Lu Yang, Xiaoli Yan, Wenya Tian, Zhihao Liu, Zhi Lin, Zixin Deng, Xudong Qu, 2022 A dual role reductase from phytosterol catabolism enables efficient production of valuable steroid precursors., Haidong Peng, Yaya Wang, Yanan Zhang, Zixing Deng, Zhenghua Tian, Xudong Qu, 2021 Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric ketopiperazines., Chenghai Sun, Zhenyao Luo (co-first author), Wenlu Zhang, Wenya Tian, Haidong Peng, Zhi Lin, Xiaoli Yan, Yanan Zhang, Zixin Deng, Bostjan Kobe, Xinying Jia, Xudong Qu, 2020 Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids., Wenya Tian, Chenghai Sun (co-first author), Mei Zheng, Mingjia Yu, Yanan Zhang, Haidong Peng, Dongqing Zhu, Jeffery Harmer, Zixin Deng, Shilu Chen, Mohedi Mobli, Xinying Jia, Xudong Qu, 2018 Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into Polyketide carbon scaffolds., Chengcheng Chang, Rong Huang (co-first author), Yan Yan, Hongmin Ma, Zheng Dai, Benying Zhang, Wen Liu, Zixin Deng, Xudong Qu, 2015

Areas of Focus

Directed biosynthesis of natural products

Publications

An unusual aromatase/cyclase programs the formation of the phenyldimethylanthrone framework in anthrabenzoxocinones and fasamycin., Kai Jiang, Xu Chen, Xiaoli Yan, Zixin Deng, Shunkun Luo, Xudong Qu, 2024
Engineering the substrate specificity of a P450 dimerase enables the collective biosynthesis of heterodimeric tryptophan-containing diketopiperazines., Chenghai Sun, Bao-Di Ma, Guangjun Li, Wenya Tian, Lu Yang, Haidong Peng, Zhi Lin, Zixin Deng, Xu-Dong Kong, Xudong Qu, 2023
A large conserved family of small-molecule carboxyl methyltransferases identified from microorganisms., Zhi Lin, Zhiwei Hu, Linjun Zhou, Benben Liu, Xiaowei Huang, Zixin Deng, Xudong Qu, 2023
A chemoenzymatic approach to C14-functionalized steroids., Fuzheng Song, Mengmeng Zheng, Junlin Wang, Huanhuan Liu, Zhi Lin, Bengbeng Liu, Zixin Deng, Qianghui Zhou, Xudong Qu, 2023
A pair of atypical KAS III homologues with initiation and elongation functions programs the polyketide biosynthesis in asukamycin., Xiaoli Yan, Jun Zhang, Hongqun Tan, Zhihao Liu, Kai Jiang, Wenya Tian, Mengmeng Zheng, Zhi Lin, Zixin Deng, Xudong Qu, 2022
An atypical acyl-CoA synthetase enables efficient biosynthesis of extender units for engineering a polyketide carbon scaffold., Mengmeng Zheng, Jun Zhang, Wan Zhang, Lu Yang, Xiaoli Yan, Wenya Tian, Zhihao Liu, Zhi Lin, Zixin Deng, Xudong Qu, 2022
A dual role reductase from phytosterol catabolism enables efficient production of valuable steroid precursors., Haidong Peng, Yaya Wang, Yanan Zhang, Zixing Deng, Zhenghua Tian, Xudong Qu, 2021
Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric ketopiperazines., Chenghai Sun, Zhenyao Luo (co-first author), Wenlu Zhang, Wenya Tian, Haidong Peng, Zhi Lin, Xiaoli Yan, Yanan Zhang, Zixin Deng, Bostjan Kobe, Xinying Jia, Xudong Qu, 2020
Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids., Wenya Tian, Chenghai Sun (co-first author), Mei Zheng, Mingjia Yu, Yanan Zhang, Haidong Peng, Dongqing Zhu, Jeffery Harmer, Zixin Deng, Shilu Chen, Mohedi Mobli, Xinying Jia, Xudong Qu, 2018
Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into Polyketide carbon scaffolds., Chengcheng Chang, Rong Huang (co-first author), Yan Yan, Hongmin Ma, Zheng Dai, Benying Zhang, Wen Liu, Zixin Deng, Xudong Qu, 2015

Biosynthesis Natural Products Drug Development Structural Optimization Chemical Synthesis Enzyme Engineering Synthetic Biology Polyketides Alkaloids Steroid Drugs

Xudong Qu - Shanghai Jiao Tong University

Yinhua Lu - Shanghai Normal University

Hua Yuan - Shanghai Normal University

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