Areas of Focus
- Microbial origin bioactive natural products biosynthesis
- Antibiotic-producing bacteria self-resistance and regulatory mechanisms
- Genomic information guided active natural products mining
Work Experience
- 2019.12-present, Shanghai Normal University, Researcher
- 2014.5-2019.11, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Associate Researcher
- 2014.3-2014.5, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Assistant Researcher
- 2012.3-2014.3, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Postdoctoral Researcher
Academic Background & Achievements
- 2008-2012 PhD: Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences
- 2005-2008 Master's: Anhui University
Publications
- Characterization of the rifamycin-degrading monooxygenase from rifamycin producers implicating its involvement in saliniketal biosynthesis, Zheng XF, Liu XQ, Peng SY, Zhou Q, Xu B, Yuan H, Tang GL, 2020
- Recent advances in HemN-like radical S-adenosyl-L-methionine enzyme-catalyzed reactions, Jin WB, Wu S, Xu YF, Yuan H, Tang GL, 2020
- A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis, Jin WB, Wu S, Jian XH, Yuan H, Tang GL, 2018
- Bioinformatics-guided connection of a biosynthetic gene cluster to the antitumor antibiotic gilvusmycin, Wang X, Wu S, Jin W, Xu B, Tang GL, Yuan H, 2018
- GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection, Yuan H, Zhang J, Cai Y, Wu S, Yang K, Chan HCS, Huang W, Jin WB, Li Y, Yin Y, Igarashi Y, Yuan S, Zhou J, Tang GL, 2017
- Unified biosynthetic origin of the benzodipyrrole subunits in CC-1065, Wu S, Jian XH, Yuan H, Jin WB, Yin Y, Wang LY, Zhao J, Tang GL, 2017
- The SARP family regulator Txn9 and two-component response regulator Txn11 are key activators for trioxacarcin biosynthesis in Streptomyces bottropensis, Yang K, Qi LH, Zhang M, Hou XF, Pan HX, Tang GL, Wang W, Yuan H, 2015
- Two genes, rif15 and rif16, of the rifamycin biosynthetic gene cluster in Amycolatopsis mediterranei likely encode a transketolase and a P450 monooxygenase, respectively, both essential for the conversion of rifamycin SV into B, Yuan H, Zhao W, Zhong Y, Wang J, Qin Z, Ding X, Zhao GP, 2011
- Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism, Zhao W, Zhong Y, Yuan H, Wang J, Zheng H, Wang Y, Cen X, Xu F, Bai J, Han X, Lu G, Zhu Y, Shao Z, Yan H, Li C, Peng N, Zhang Z, Zhang Y, Lin W, Fan Y, Qin Z, Hu Y, Zhu B, Wang S, Ding X, Zhao GP, 2010
