Areas of Focus
- 微生物来源活性天然产物的生物合成
- 抗生素产生菌自抗性与调控机制解析
- 基因组信息指导的活性天然产物挖掘
Work Experience
- 2019.12-至今，上海师范大学，研究员
- 2014.5-2019.11，中国科学院上海有机化学研究所，副研究员
- 2014.3-2014.5，中国科学院上海有机化学研究所，助理研究员
- 2012.3-2014.3，中国科学院上海有机化学研究所，博士后
Academic Background & Achievements
- 2008-2012 博士：中国科学院上海植物生理生态研究所
- 2005-2008 硕士：安徽大学
Publications
- Characterization of the rifamycin-degrading monooxygenase from rifamycin producers implicating its involvement in saliniketal biosynthesis, Zheng XF, Liu XQ, Peng SY, Zhou Q, Xu B, Yuan H, Tang GL, 2020
- Recent advances in HemN-like radical S-adenosyl-L-methionine enzyme-catalyzed reactions, Jin WB, Wu S, Xu YF, Yuan H, Tang GL, 2020
- A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis, Jin WB, Wu S, Jian XH, Yuan H, Tang GL, 2018
- Bioinformatics-guided connection of a biosynthetic gene cluster to the antitumor antibiotic gilvusmycin, Wang X, Wu S, Jin W, Xu B, Tang GL, Yuan H, 2018
- GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection, Yuan H, Zhang J, Cai Y, Wu S, Yang K, Chan HCS, Huang W, Jin WB, Li Y, Yin Y, Igarashi Y, Yuan S, Zhou J, Tang GL, 2017
- Unified biosynthetic origin of the benzodipyrrole subunits in CC-1065, Wu S, Jian XH, Yuan H, Jin WB, Yin Y, Wang LY, Zhao J, Tang GL, 2017
- The SARP family regulator Txn9 and two-component response regulator Txn11 are key activators for trioxacarcin biosynthesis in Streptomyces bottropensis, Yang K, Qi LH, Zhang M, Hou XF, Pan HX, Tang GL, Wang W, Yuan H, 2015
- Two genes, rif15 and rif16, of the rifamycin biosynthetic gene cluster in Amycolatopsis mediterranei likely encode a transketolase and a P450 monooxygenase, respectively, both essential for the conversion of rifamycin SV into B, Yuan H, Zhao W, Zhong Y, Wang J, Qin Z, Ding X, Zhao GP, 2011
- Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism, Zhao W, Zhong Y, Yuan H, Wang J, Zheng H, Wang Y, Cen X, Xu F, Bai J, Han X, Lu G, Zhu Y, Shao Z, Yan H, Li C, Peng N, Zhang Z, Zhang Y, Lin W, Fan Y, Qin Z, Hu Y, Zhu B, Wang S, Ding X, Zhao GP, 2010
