Areas of Focus
- 重要生物活性天然产物的生物合成机制和合成生物学研究
- 极端环境微生物中活性小分子和高效酶的发现
- 酶催化机制的多样性和定向进化研究
- 重要临床药物中间体的生物催化和微生物工业菌种的代谢工程
Work Experience
- 2019-至今：上海交通大学生命科学技术学院，特别研究员、博导
- 2013-2018：兰州大学生命科学院，副教授、硕导
- 2010-2012：德国Saarland University，药物生物技术系，博士后
Academic Background & Achievements
- 2006-2010 博士：兰州大学生命科学院和中科院上海有机化学研究所
- 2001-2005 本科：兰州大学生命科学院
Publications
- Tianlv Mo, Dhanaraju Mandalapu, Hong Yuan, Wei Ding* and Qi Zhang*. Convergent evolution of the Cys decarboxylases involved in aminovinyl-cysteine (AviCys) biosynthesis. FEBS Letters. 2019, 593(6):573-580., Tianlv Mo, Dhanaraju Mandalapu, Hong Yuan, Wei Ding*, Qi Zhang*, 2019
- Wei Ding#, Ning Yuan#, Dhanaraju Mandalapu, Tianlu Mo, Suwei Dong* and Qi Zhang*. Cypemycin Decarboxylase CypD Is Not Responsible for Aminovinyl–Cysteine (AviCys) Ring Formation. Org. Lett., 2018, 20 (23):7670–7673., Wei Ding#, Ning Yuan#, Dhanaraju Mandalapu, Tianlu Mo, Suwei Dong*, Qi Zhang*, 2018
- Wei Ding, Tianlu Mo, Dhanaraju Mandalapu, Qi Zhang*. Substrate specificity of the cypemycin decarboxylase CypD. Synth Syst Biotechnol. 2018, 3(3):159-162, Wei Ding, Tianlu Mo, Dhanaraju Mandalapu, Qi Zhang*, 2018
- Yujie Wu, Runze Wu, Dhanaraju Mandalapu, Xinjian Ji, Tuo Chen, Wei Ding and Qi Zhang. Radical SAM-dependent adenosylation catalyzed by L-tyrosine lyases. Org Biomol Chem. 2018, 17(7):1809-1812., Yujie Wu, Runze Wu, Dhanaraju Mandalapu, Xinjian Ji, Tuo Chen, Wei Ding, Qi Zhang, 2018
- Xinjian Ji, Dhanaraju Mandalapu, Jinduo Cheng, Wei Ding, Qi Zhang*. Expanding the Chemistry of the Class C Radical SAM Methyltransferase NosN by Using an Allyl Analogue of SAM. Angew Chem Int Ed Engl. 2018, 57(22):6601-6604., Xinjian Ji, Dhanaraju Mandalapu, Jinduo Cheng, Wei Ding, Qi Zhang*, 2018
- Dhanaraju Mandalapu, Xinjian Ji, Jinfeng Chen, Chuchu Guo, Wan-Qiu Liu, Wei Ding, Jiahai Zhou, and Qi Zhang. Thioesterase-Mediated Synthesis of Teixobactin Analogues: Mechanism and Substrate Specificity. J Org Chem. 2018, 83(13):7271-7275., Dhanaraju Mandalapu, Xinjian Ji, Jinfeng Chen, Chuchu Guo, Wan-Qiu Liu, Wei Ding, Jiahai Zhou, Qi Zhang, 2018
- Thongkongkaew Tawatchai, Ding Wei, Bratovanov Evgeni, Oueis Emilia, Garcia Altares Maria, Zaburannyi Nestor, Harmrolfs Kirsten, Zhang Youming, Scherlach Kirstin, Mueller Rolf* and Hertweck Christian*. Two Types of Threonine-Tagged Lipopeptides Synergize in Host Colonization by Pathogenic Burkholderia Species. ACS Chemical Biology. 2018, 13(5): 1370-1379., Thongkongkaew Tawatchai, Ding Wei, Bratovanov Evgeni, Oueis Emilia, Garcia Altares Maria, Zaburannyi Nestor, Harmrolfs Kirsten, Zhang Youming, Scherlach Kirstin, Mueller Rolf*, Hertweck Christian*, 2018
- Wei Ding, Wenjuan Ji, Yujie Wu, Runze Wu, Wan-Qiu Liu, Tianlu Mo, Junfeng Zhao, Xiaoyan Ma, Ping Xu, Boping Tang*, Yi Yu* and Qi Zhang*. Biosynthesis of the Nosiheptide Indole Side Ring Centers on a Cryptic Carrier Protein NosJ. Nature Communications. 2017, 8(1):437., Wei Ding, Wenjuan Ji, Yujie Wu, Runze Wu, Wan-Qiu Liu, Tianlu Mo, Junfeng Zhao, Xiaoyan Ma, Ping Xu, Boping Tang*, Yi Yu*, Qi Zhang*, 2017
- Wei Ding, Yongzhen Li, Junfeng Zhao, Xinjian Ji, Tianlu Mo, Haocheng Qianzhu, Zixin Deng, Yi Yu, and Qi Zhang*. Catalytic Mechanism of the Class C radical S-Adenosylmethionine Methyltransferase. Angew. Chem. Int. Ed. 2017, 56, 3857 -3861., Wei Ding, Yongzhen Li, Junfeng Zhao, Xinjian Ji, Tianlu Mo, Haocheng Qianzhu, Zixin Deng, Yi Yu, Qi Zhang*, 2017
- Wei Ding, Yujie Wu, Xinjian Ji, Haocheng Qianzhu, Fener Chen, Zixin Deng, Yi Yu and Qi Zhang*. Nucleoside-linked Shunt Products in the Reaction Catalyzed by the Class C Radical S-Adenosylmethionine Methyltransferase NosN. Chemical Communications. 2017, 53, 5235-5238., Wei Ding, Yujie Wu, Xinjian Ji, Haocheng Qianzhu, Fener Chen, Zixin Deng, Yi Yu, Qi Zhang*, 2017
