Areas of Focus
- Biosynthesis mechanisms and synthetic biology of important bioactive natural products
- Discovery of active small molecules and efficient enzymes in extreme environmental microbes
- Diversity and directed evolution of enzyme catalysis mechanisms
- Biocatalysis and microbial industrial strains of important clinical drug intermediates
Work Experience
- 2019-present: Shanghai Jiao Tong University, School of Life Sciences and Technology, Special Research Fellow, Doctoral Supervisor
- 2013-2018: Lanzhou University, School of Life Sciences, Associate Professor, Master's Supervisor
- 2010-2012: Saarland University, Germany, Department of Pharmaceutical Biotechnology, Postdoctoral Researcher
Academic Background & Achievements
- 2006-2010 PhD: Lanzhou University and Shanghai Institute of Organic Chemistry, CAS
- 2001-2005 Bachelor: Lanzhou University, School of Life Sciences
Publications
- Convergent evolution of the Cys decarboxylases involved in aminovinyl-cysteine (AviCys) biosynthesis, Tianlv Mo, Dhanaraju Mandalapu, Hong Yuan, Wei Ding*, Qi Zhang*, 2019
- Cypemycin Decarboxylase CypD Is Not Responsible for Aminovinyl–Cysteine (AviCys) Ring Formation, Wei Ding#, Ning Yuan#, Dhanaraju Mandalapu, Tianlu Mo, Suwei Dong*, Qi Zhang*, 2018
- Substrate specificity of the cypemycin decarboxylase CypD, Wei Ding, Tianlu Mo, Dhanaraju Mandalapu, Qi Zhang*, 2018
- Radical SAM-dependent adenosylation catalyzed by L-tyrosine lyases, Yujie Wu, Runze Wu, Dhanaraju Mandalapu, Xinjian Ji, Tuo Chen, Wei Ding, Qi Zhang, 2018
- Expanding the Chemistry of the Class C Radical SAM Methyltransferase NosN by Using an Allyl Analogue of SAM, Xinjian Ji, Dhanaraju Mandalapu, Jinduo Cheng, Wei Ding, Qi Zhang*, 2018
- Thioesterase-Mediated Synthesis of Teixobactin Analogues: Mechanism and Substrate Specificity, Dhanaraju Mandalapu, Xinjian Ji, Jinfeng Chen, Chuchu Guo, Wan-Qiu Liu, Wei Ding, Jiahai Zhou, Qi Zhang, 2018
- Two Types of Threonine-Tagged Lipopeptides Synergize in Host Colonization by Pathogenic Burkholderia Species, Thongkongkaew Tawatchai, Ding Wei, Bratovanov Evgeni, Oueis Emilia, Garcia Altares Maria, Zaburannyi Nestor, Harmrolfs Kirsten, Zhang Youming, Scherlach Kirstin, Mueller Rolf*, Hertweck Christian*, 2018
- Biosynthesis of the Nosiheptide Indole Side Ring Centers on a Cryptic Carrier Protein NosJ, Wei Ding, Wenjuan Ji, Yujie Wu, Runze Wu, Wan-Qiu Liu, Tianlu Mo, Junfeng Zhao, Xiaoyan Ma, Ping Xu, Boping Tang*, Yi Yu*, Qi Zhang*, 2017
- Catalytic Mechanism of the Class C radical S-Adenosylmethionine Methyltransferase, Wei Ding, Yongzhen Li, Junfeng Zhao, Xinjian Ji, Tianlu Mo, Haocheng Qianzhu, Zixin Deng, Yi Yu, Qi Zhang*, 2017
- Nucleoside-linked Shunt Products in the Reaction Catalyzed by the Class C Radical S-Adenosylmethionine Methyltransferase NosN, Wei Ding, Yujie Wu, Xinjian Ji, Haocheng Qianzhu, Fener Chen, Zixin Deng, Yi Yu, Qi Zhang*, 2017
