Professor | Shuangjun Lin | Asia Growth Partners

Name	Shuangjun Lin
Contact Information	linsj@sjtu.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Shuangjun Lin

Contact Information

linsj@sjtu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Shanghai Jiao Tong University
Faculty	Life Sciences
Academic Background & Achievements	1999-2002 PhD in Organic Chemistry, Chinese Academy of Sciences, Supervisor: Professor Meixiang Wang 1996-1999 Master's in Organic Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Supervisor: Researcher Dayuan Zhu 1992-1996 Bachelor's in Organic Chemistry, Jilin University
Work Experience	2015-present Distinguished Professor, Doctoral Supervisor at Shanghai Jiao Tong University 2009-2014 Researcher at Shanghai Jiao Tong University 2005-2008 Research Assistant at University of Wisconsin-Madison, USA 2002-2005 Postdoctoral Fellow at University of Alberta, Department of Chemistry, Canada
Awards	2018 Shanghai Jiao Tong University Postdoctoral Award Fund Supervisor 2016 Shanghai Outstanding Doctoral Dissertation Supervisor 2014 National Science Fund for Distinguished Young Scholars 2014 Jinyu Young Teacher Award 2012 Shanghai Jiao Tong University 'Morning Star Young Scholar Award Plan' Category A 2011 Ministry of Education 'New Century Excellent Talents Support Plan'

University/Lab Affiliation and Title

Shanghai Jiao Tong University

Faculty

Life Sciences

Academic Background & Achievements

1999-2002 PhD in Organic Chemistry, Chinese Academy of Sciences, Supervisor: Professor Meixiang Wang
1996-1999 Master's in Organic Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Supervisor: Researcher Dayuan Zhu
1992-1996 Bachelor's in Organic Chemistry, Jilin University

Work Experience

2015-present Distinguished Professor, Doctoral Supervisor at Shanghai Jiao Tong University
2009-2014 Researcher at Shanghai Jiao Tong University
2005-2008 Research Assistant at University of Wisconsin-Madison, USA
2002-2005 Postdoctoral Fellow at University of Alberta, Department of Chemistry, Canada

Awards

2018 Shanghai Jiao Tong University Postdoctoral Award Fund Supervisor
2016 Shanghai Outstanding Doctoral Dissertation Supervisor
2014 National Science Fund for Distinguished Young Scholars
2014 Jinyu Young Teacher Award
2012 Shanghai Jiao Tong University 'Morning Star Young Scholar Award Plan' Category A
2011 Ministry of Education 'New Century Excellent Talents Support Plan'

Areas of Focus	Discovery and structural identification of bioactive natural products Biosynthesis and combinatorial biosynthesis of natural products Mechanism and application of enzyme-catalyzed reactions
Publications	Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily, Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng X, Tang Y, Lin S, 2017 Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway, Lan Y, Zou Y, Huang T, Wang X, Brock NL, Deng Z, Lin S, 2016 Transformation of Streptonigrin to Streptonigrone: Flavin Reductase-Mediated Flavin-Catalyzed Concomitant Oxidative Decarboxylation of Picolinic Acid Derivatives, Wo J, Kong D, Brock NL, Xu F, Zhou X, Deng Z, Lin S, 2016 An Acyl Transfer Reaction Catalyzed by an Epimerase MarH, Han M, Yin H, Zou Y, Brock NL, Huang T, Deng Z, Chu Y, Lin S, 2016 Stereospecific biosynthesis of β-methyl tryptophan from L-tryptophan features a stereochemical switch, Zou Y, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S, 2013 Characterization of Streptonigrin Biosynthesis Reveals a Cryptic Carboxyl Methylation and an Unusual Oxidative Cleavage of a N-C Bond, Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S, 2013 Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis, Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B, 2012 A Free-Standing Condensation Enzyme Catalyzing Ester Bond Formation in C-1027 Biosynthesis, Lin S, Van Lanen SG, Shen B, 2009 Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis, Lin S, Horsman GP, Chen Y, Li W, Shen B, 2009 Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517, Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S*, Deng Z, 2011

Areas of Focus

Discovery and structural identification of bioactive natural products
Biosynthesis and combinatorial biosynthesis of natural products
Mechanism and application of enzyme-catalyzed reactions

Publications

Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily, Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng X, Tang Y, Lin S*, 2017
Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway, Lan Y, Zou Y, Huang T, Wang X, Brock NL, Deng Z, Lin S*, 2016
Transformation of Streptonigrin to Streptonigrone: Flavin Reductase-Mediated Flavin-Catalyzed Concomitant Oxidative Decarboxylation of Picolinic Acid Derivatives, Wo J, Kong D, Brock NL, Xu F, Zhou X, Deng Z, Lin S*, 2016
An Acyl Transfer Reaction Catalyzed by an Epimerase MarH, Han M, Yin H, Zou Y, Brock NL, Huang T, Deng Z, Chu Y*, Lin S*, 2016
Stereospecific biosynthesis of β-methyl tryptophan from L-tryptophan features a stereochemical switch, Zou Y, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S*, 2013
Characterization of Streptonigrin Biosynthesis Reveals a Cryptic Carboxyl Methylation and an Unusual Oxidative Cleavage of a N-C Bond, Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S*, 2013
Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis, Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B*, 2012
A Free-Standing Condensation Enzyme Catalyzing Ester Bond Formation in C-1027 Biosynthesis, Lin S, Van Lanen SG, Shen B*, 2009
Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis, Lin S, Horsman GP, Chen Y, Li W, Shen B*, 2009
Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517, Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S*, Deng Z, 2011

Bioactive Natural Products Structural Identification Microbial Antibiotics Biosynthesis Combinatorial Biosynthesis Enzyme-Catalyzed Mechanism Application

Yinhua Lu - Shanghai Normal University

Hua Yuan - Shanghai Normal University

Meifeng Tao - Shanghai Jiao Tong University

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