Areas of Focus
- Discovery and structural identification of bioactive natural products
- Biosynthesis and combinatorial biosynthesis of natural products
- Mechanism and application of enzyme-catalyzed reactions
Work Experience
- 2015-present Distinguished Professor, Doctoral Supervisor at Shanghai Jiao Tong University
- 2009-2014 Researcher at Shanghai Jiao Tong University
- 2005-2008 Research Assistant at University of Wisconsin-Madison, USA
- 2002-2005 Postdoctoral Fellow at University of Alberta, Department of Chemistry, Canada
Academic Background & Achievements
- 1999-2002 PhD in Organic Chemistry, Chinese Academy of Sciences, Supervisor: Professor Meixiang Wang
- 1996-1999 Master's in Organic Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Supervisor: Researcher Dayuan Zhu
- 1992-1996 Bachelor's in Organic Chemistry, Jilin University
Publications
- Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily, Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng X, Tang Y, Lin S*, 2017
- Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway, Lan Y, Zou Y, Huang T, Wang X, Brock NL, Deng Z, Lin S*, 2016
- Transformation of Streptonigrin to Streptonigrone: Flavin Reductase-Mediated Flavin-Catalyzed Concomitant Oxidative Decarboxylation of Picolinic Acid Derivatives, Wo J, Kong D, Brock NL, Xu F, Zhou X, Deng Z, Lin S*, 2016
- An Acyl Transfer Reaction Catalyzed by an Epimerase MarH, Han M, Yin H, Zou Y, Brock NL, Huang T, Deng Z, Chu Y*, Lin S*, 2016
- Stereospecific biosynthesis of β-methyl tryptophan from L-tryptophan features a stereochemical switch, Zou Y, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S*, 2013
- Characterization of Streptonigrin Biosynthesis Reveals a Cryptic Carboxyl Methylation and an Unusual Oxidative Cleavage of a N-C Bond, Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S*, 2013
- Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis, Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B*, 2012
- A Free-Standing Condensation Enzyme Catalyzing Ester Bond Formation in C-1027 Biosynthesis, Lin S, Van Lanen SG, Shen B*, 2009
- Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis, Lin S, Horsman GP, Chen Y, Li W, Shen B*, 2009
- Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517, Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S*, Deng Z, 2011
Awards
- 2018 Shanghai Jiao Tong University Postdoctoral Award Fund Supervisor
- 2016 Shanghai Outstanding Doctoral Dissertation Supervisor
- 2014 National Science Fund for Distinguished Young Scholars
- 2014 Jinyu Young Teacher Award
- 2012 Shanghai Jiao Tong University 'Morning Star Young Scholar Award Plan' Category A
- 2011 Ministry of Education 'New Century Excellent Talents Support Plan'
