Areas of Focus
- Molecular regulation of microbial natural drug biosynthesis
- Development of microbial natural drugs based on synthetic biology strategies
Work Experience
- 2017/7-present, Shanghai Normal University - Researcher
- 2013/12-2017/6, Shanghai Institute of Plant Physiology and Ecology, CAS - Researcher
- 2009/3-2010/2, University of Erlangen, Germany - Visiting Scholar
- 2008/3-2013/11, Shanghai Institute of Plant Physiology and Ecology, CAS - Associate Researcher
- 2006/06-2008/02, Shanghai Institute of Plant Physiology and Ecology, CAS - Assistant Researcher
- 2003/07-2006/05, Shanghai Institute of Plant Physiology and Ecology, CAS - Postdoctoral Researcher
Academic Background & Achievements
- 2000-2003 PhD: Nanjing Agricultural University
- 1997-2000 Master's: Yangzhou University
- 1992-1997 Bachelor's: Yangzhou University
Publications
- A novel two-component, GluR-K, involved in glutamate sensing and uptake in Streptomyces coelicolor, Li L, Jiang WH, Lu YH, 2017
- New strategies and approaches for engineering biosynthetic gene clusters of microbial natural products, Li L, Jiang WH, Lu YH, 2017
- Multiplexed site-specific genome engineering for overproducing bioactive secondary metabolites in actinomycetes, Li L, Zheng GS, Chen J, Ge M, Jiang WH, Lu YH, 2017
- Direct involvement of the master nitrogen metabolism regulator in antibiotic biosynthesis in Streptomyces, He JM, Zhu H, Zheng GS, Liu PP, Wang J, Zhao GP, Zhu GQ, Jiang WH, Lu YH, 2016
- A stepwise increase in pristinamycin II biosynthesis by Streptomyces pristinaespiralis through combinatorial metabolic engineering, Li L, Zhao YW, Ruan LJ, Yang S, Ge M, Jiang WH, Lu YH, 2015
- Involvement of the TetR-type regulator PaaR in the regulation of pristinamycin I biosynthesis through effect on precursor supply in Streptomyces pristinaespiralis, Zhao YW, Feng RR, Zheng GS, Tian JZ, Ruan LJ, Ge M, Jiang WH, Lu YH, 2015
- PapR6, a putative atypical response regulator, functions as a pathway-specific activator of pristinamycin II biosynthesis in Streptomyces pristinaespiralis, Dun JL, Zhao YW, Zheng GS, Zhu H, Ruan LJ, Wang WF, Ge M, Jiang WH, Lu YH, 2015
- Identification of two novel regulatory genes involved in pristinamycin biosynthesis and elucidation of the mechanism for AtrA-p-mediated regulation in Streptomyces pristinaespiralis, Wang WF, Tian JZ, Li L, Ge M, Zhu H, Zheng GS, Huang H, Ruan LJ, Jiang WH, Lu YH, 2015
- Identification of two-component system AfsQ1/Q2 regulon and its cross-regulation with GlnR in Streptomyces coelicolor, Wang R, Mast Y, Wang J, Zhang WW, Zhao GP, Wohlleben W, Lu YH, Jiang WH, 2013
- Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor, Yu ZY, Zhu H, Dang FJ, Zhang WW, Qin ZJ, Yang S, Tan HH, Lu YH, Jiang WH, 2012
Awards
- Sanofi-Shanghai Institute of Life Sciences Excellent Young Talent Fund, 2012
