Professor | 林双君 | 数字化转型顾问

Name	林双君
Contact Information	linsj@sjtu.edu.cn
Language ability	中文, 英语
Province	上海

Name

林双君

Contact Information

linsj@sjtu.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	上海交通大学
Faculty	Life Sciences
Academic Background & Achievements	1999-2002 中国科学院化学研究所，有机化学，博士，导师：王梅祥教授 1996-1999 中科院上海药物研究所，有机化学，硕士，导师：朱大元研究员 1992-1996 吉林大学化学系，有机化学，学士
Work Experience	2015-迄今上海交通大学，特聘教授、博士生导师 2009-2014 上海交通大学，研究员 2005-2008 美国威斯康星大学麦迪逊分校，研究助理 2002-2005 加拿大埃尔伯塔大学化学系，博士后
Awards	2018 上海交通大学博士后奖励基金指导教师 2016 上海市优秀博士论文指导教师 2014 国家杰出青年科学基金获得者 2014 金龙鱼青年教师奖 2012 上海交通大学“晨星青年学者奖励计划”A类 2011 教育部“新世纪优秀人才支持计划”

University/Lab Affiliation and Title

上海交通大学

Faculty

Life Sciences

Academic Background & Achievements

1999-2002 中国科学院化学研究所，有机化学，博士，导师：王梅祥教授
1996-1999 中科院上海药物研究所，有机化学，硕士，导师：朱大元研究员
1992-1996 吉林大学化学系，有机化学，学士

Work Experience

2015-迄今上海交通大学，特聘教授、博士生导师
2009-2014 上海交通大学，研究员
2005-2008 美国威斯康星大学麦迪逊分校，研究助理
2002-2005 加拿大埃尔伯塔大学化学系，博士后

Awards

2018 上海交通大学博士后奖励基金指导教师
2016 上海市优秀博士论文指导教师
2014 国家杰出青年科学基金获得者
2014 金龙鱼青年教师奖
2012 上海交通大学“晨星青年学者奖励计划”A类
2011 教育部“新世纪优秀人才支持计划”

Areas of Focus	生物活性天然产物的发现及结构鉴定天然产物的生物合成与组合生物合成酶催化反应的机理和应用
Publications	Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng X, Tang Y, Lin S. Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily. J Am Chem Soc 2017, 139(34):11887-94., Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng X, Tang Y, Lin S, 2017 Lan Y, Zou Y, Huang T, Wang X, Brock NL, Deng Z, Lin S. Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway. Science China-Chemistry, 2016, 59, 1224-8., Lan Y, Zou Y, Huang T, Wang X, Brock NL, Deng Z, Lin S, 2016 Wo J, Kong D, Brock NL, Xu F, Zhou X, Deng Z, Lin S. Transformation of Streptonigrin to Streptonigrone: Flavin Reductase-Mediated Flavin-Catalyzed Concomitant Oxidative Decarboxylation of Picolinic Acid Derivatives. ACS Catal. 2016, 6, 2831-5., Wo J, Kong D, Brock NL, Xu F, Zhou X, Deng Z, Lin S, 2016 Han M, Yin H, Zou Y, Brock NL, Huang T, Deng Z, Chu Y, Lin S. An Acyl Transfer Reaction Catalyzed by an Epimerase MarH. ACS Catal., 2016, 6, 788-92., Han M, Yin H, Zou Y, Brock NL, Huang T, Deng Z, Chu Y, Lin S, 2016 Zou Y, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S. Stereospecific biosynthesis of β-methyl tryptophan from L-tryptophan features a stereochemical switch. Angew Chem Int Ed, 2013, 52, 12951-5., Zou Y, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S, 2013 Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S. Characterization of Streptonigrin Biosynthesis Reveals a Cryptic Carboxyl Methylation and an Unusual Oxidative Cleavage of a N-C Bond. J Am Chem Soc. 2013, 135, 1739-48., Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S, 2013 Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B. Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis. Org Lett. 2012, 14, 2300-3., Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B, 2012 Lin S, Van Lanen SG, Shen B. A Free-Standing Condensation Enzyme Catalyzing Ester Bond Formation in C-1027 Biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 4183-8., Lin S, Van Lanen SG, Shen B, 2009 Lin S, Horsman GP, Chen Y, Li W, Shen B. Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis. J Am Chem Soc. 2009, 131, 16410-7., Lin S, Horsman GP, Chen Y, Li W, Shen B, 2009 Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S, Deng Z. Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517. J Biol Chem. 2011, 286, 20648-57., Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S, Deng Z, 2011

Areas of Focus

生物活性天然产物的发现及结构鉴定
天然产物的生物合成与组合生物合成
酶催化反应的机理和应用

Publications

Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng X, Tang Y, Lin S*. Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily. J Am Chem Soc 2017, 139(34):11887-94., Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng X, Tang Y, Lin S*, 2017
Lan Y, Zou Y, Huang T, Wang X, Brock NL, Deng Z, Lin S*. Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway. Science China-Chemistry, 2016, 59, 1224-8., Lan Y, Zou Y, Huang T, Wang X, Brock NL, Deng Z, Lin S*, 2016
Wo J, Kong D, Brock NL, Xu F, Zhou X, Deng Z, Lin S*. Transformation of Streptonigrin to Streptonigrone: Flavin Reductase-Mediated Flavin-Catalyzed Concomitant Oxidative Decarboxylation of Picolinic Acid Derivatives. ACS Catal. 2016, 6, 2831-5., Wo J, Kong D, Brock NL, Xu F, Zhou X, Deng Z, Lin S*, 2016
Han M, Yin H, Zou Y, Brock NL, Huang T, Deng Z, Chu Y*, Lin S*. An Acyl Transfer Reaction Catalyzed by an Epimerase MarH. ACS Catal., 2016, 6, 788-92., Han M, Yin H, Zou Y, Brock NL, Huang T, Deng Z, Chu Y*, Lin S*, 2016
Zou Y, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S*. Stereospecific biosynthesis of β-methyl tryptophan from L-tryptophan features a stereochemical switch. Angew Chem Int Ed, 2013, 52, 12951-5., Zou Y, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S*, 2013
Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S*. Characterization of Streptonigrin Biosynthesis Reveals a Cryptic Carboxyl Methylation and an Unusual Oxidative Cleavage of a N-C Bond. J Am Chem Soc. 2013, 135, 1739-48., Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S*, 2013
Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B*. Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis. Org Lett. 2012, 14, 2300-3., Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B*, 2012
Lin S, Van Lanen SG, Shen B*. A Free-Standing Condensation Enzyme Catalyzing Ester Bond Formation in C-1027 Biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 4183-8., Lin S, Van Lanen SG, Shen B*, 2009
Lin S, Horsman GP, Chen Y, Li W, Shen B*. Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis. J Am Chem Soc. 2009, 131, 16410-7., Lin S, Horsman GP, Chen Y, Li W, Shen B*, 2009
Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S*, Deng Z. Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517. J Biol Chem. 2011, 286, 20648-57., Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S*, Deng Z, 2011

生物活性天然产物结构鉴定微生物抗生素生物合成组合生物合成酶催化机理应用

袁华 - 上海师范大学

Area of Focus
生物合成 | 微生物 | 天然产物 | 抗生素 | 自抗性 | 调控机制 | 基因组信息 | 挖掘 | 活性 | 细菌

杨帆 - 上海师范大学

赵军 - 上海师范大学

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