Areas of Focus
- 生物活性天然产物的发现及结构鉴定
- 天然产物的生物合成与组合生物合成
- 酶催化反应的机理和应用
Work Experience
- 2015-迄今 上海交通大学，特聘教授、博士生导师
- 2009-2014 上海交通大学，研究员
- 2005-2008 美国威斯康星大学麦迪逊分校，研究助理
- 2002-2005 加拿大埃尔伯塔大学化学系，博士后
Academic Background & Achievements
- 1999-2002 中国科学院化学研究所，有机化学，博士，导师：王梅祥教授
- 1996-1999 中科院上海药物研究所，有机化学，硕士，导师：朱大元研究员
- 1992-1996 吉林大学化学系，有机化学，学士
Publications
- Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng X, Tang Y, Lin S*. Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily. J Am Chem Soc 2017, 139(34):11887-94., Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng X, Tang Y, Lin S*, 2017
- Lan Y, Zou Y, Huang T, Wang X, Brock NL, Deng Z, Lin S*. Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway. Science China-Chemistry, 2016, 59, 1224-8., Lan Y, Zou Y, Huang T, Wang X, Brock NL, Deng Z, Lin S*, 2016
- Wo J, Kong D, Brock NL, Xu F, Zhou X, Deng Z, Lin S*. Transformation of Streptonigrin to Streptonigrone: Flavin Reductase-Mediated Flavin-Catalyzed Concomitant Oxidative Decarboxylation of Picolinic Acid Derivatives. ACS Catal. 2016, 6, 2831-5., Wo J, Kong D, Brock NL, Xu F, Zhou X, Deng Z, Lin S*, 2016
- Han M, Yin H, Zou Y, Brock NL, Huang T, Deng Z, Chu Y*, Lin S*. An Acyl Transfer Reaction Catalyzed by an Epimerase MarH. ACS Catal., 2016, 6, 788-92., Han M, Yin H, Zou Y, Brock NL, Huang T, Deng Z, Chu Y*, Lin S*, 2016
- Zou Y, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S*. Stereospecific biosynthesis of β-methyl tryptophan from L-tryptophan features a stereochemical switch. Angew Chem Int Ed, 2013, 52, 12951-5., Zou Y, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S*, 2013
- Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S*. Characterization of Streptonigrin Biosynthesis Reveals a Cryptic Carboxyl Methylation and an Unusual Oxidative Cleavage of a N-C Bond. J Am Chem Soc. 2013, 135, 1739-48., Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S*, 2013
- Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B*. Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis. Org Lett. 2012, 14, 2300-3., Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B*, 2012
- Lin S, Van Lanen SG, Shen B*. A Free-Standing Condensation Enzyme Catalyzing Ester Bond Formation in C-1027 Biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 4183-8., Lin S, Van Lanen SG, Shen B*, 2009
- Lin S, Horsman GP, Chen Y, Li W, Shen B*. Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis. J Am Chem Soc. 2009, 131, 16410-7., Lin S, Horsman GP, Chen Y, Li W, Shen B*, 2009
- Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S*, Deng Z. Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517. J Biol Chem. 2011, 286, 20648-57., Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S*, Deng Z, 2011
Awards
- 2018 上海交通大学博士后奖励基金指导教师
- 2016 上海市优秀博士论文指导教师
- 2014 国家杰出青年科学基金获得者
- 2014 金龙鱼青年教师奖
- 2012 上海交通大学“晨星青年学者奖励计划”A类
- 2011 教育部“新世纪优秀人才支持计划”
