2008-09--2012-02 Joint PhD: Harvard Medical School
2007-09--2012-02 PhD: Li Ka Shing Faculty of Medicine, University of Hong Kong
2005-09--2007-07 Master's: School of Medicine, Tsinghua University
2001-09--2005-07 Bachelor's: Department of Biological Sciences and Technology, Tsinghua University
2017-01~Present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Researcher, Assistant Director
2012-02~2016-12 - Stanford University School of Medicine - Postdoctoral Fellow. Supervisor: Calvin J. Kuo
2021.01: Annual Outstanding Employee, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
2020.01: Annual Outstanding Employee, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
2015-2016: Postdoctoral Fellowship, American Heart Association, Dallas, Texas, USA
2014: Travel Scholarship, 6th Mayo Clinic Angiogenesis Forum, Minnesota, USA
2009: Graduate Overseas Exchange Scholarship, University of Hong Kong, Hong Kong
2007-2011: University Postgraduate Scholarship (Outstanding Graduate), University of Hong Kong, Hong Kong
2006: Guanghua Scholarship Second Prize, Tsinghua University, Beijing, China
2004: Outstanding Social Activity Scholarship, Tsinghua University, Beijing, China
2002: Outstanding Social Activity Scholarship, Tsinghua University, Beijing, China
Research
Physiological and pathological regulation mechanisms of cerebrovascular and blood-brain barrier functions Intervention targets and new drug development for cerebrovascular and related neurological diseases Antibody drug development for metabolic disorders and cardiovascular diseases
An MMP-9 exclusive neutralizing antibody attenuates blood-brain barrier breakdown in mice with stroke and reduced stroke patient-derived MMP-9 activity, Yabin Ji, Qiang Gao, Yinzhong Ma, Fang Wang, Xixi Tan, Dengpan Song, Ruby L.C. Hoo, Zening Wang, Xin Ge, Hongjie Han, Fuyou Guo, Junlei Chang, 2023
Spatiotemporal lipidomics reveals key features of brain lipid dynamic changes after cerebral ischemia and reperfusion therapy, Yinzhong Ma, Zhiyu Chen, Qianyan He, Zhen-Ni Guo, Yi Yang, Fulin Liu, Fang Li, Qian Luo, Junlei Chang, 2022
Discovery of Cobimetinib as a novel A-FABP inhibitor using machine learning and molecular docking-based virtual screening, Shilun Yang, Simeng Li, Junlei Chang, 2022
Endothelial b-catenin deficiency causes blood-brain barrier breakdown via enhancing the paracellular and transcellular permeability, Basharat Hussain, Cheng Fang, Xiaowen Huang, Ziying Feng, Yuxuan Yao, Yu Wang, Junlei Chang, 2022
Identification of pathogenic mutations in three primary microcephaly (MCPH) related genes CENPJ, CASK and MCPH1 in consanguineous Pakistani families, Niaz Muhammad Khan, Muhammad Shareef Masoud, Shahid Mahmood Baig, Muhammad Qasim, Junlei Chang, 2022
Lithium attenuates blood-brain barrier damage and brain edema following intracerebral hemorrhage via an endothelial Wnt/β-catenin signaling-dependent mechanism in mice, Dengpan Song, Yabin Ji, Xiaowen Huang, Yinzhong Ma, Cheng Fang, Linhui Qiu, Xixi Tan, Yiman Chen, Shengnan Wang, Junlei Chang, Fuyou Guo, 2022
The role of immune cells in post-stroke angiogenesis and neuronal remodeling: the known and the unknown, Yinzhong Ma, Shilun Yang, Qianyan He, Dianhui Zhang, Junlei Chang, 2021
GAS6/Axl Signaling Modulates Blood-Brain Barrier Function Following Intravenous Thrombolysis in Acute Ischemic Stroke, Guo ZN, Liu J, Chang J, Zhang P, Jin H, Sun X, Yang Y, 2021
RIOK2 Inhibitor NSC139021 Exerts Anti-Tumor Effects on Glioblastoma via Inducing Skp2-Mediated Cell Cycle Arrest and Apoptosis, Min Yu, Xiaoyan Hu, Jingyu Yan, Ying Wang, Fei Lu, Junlei Chang, 2021
Blood-brain barrier breakdown: an emerging biomarker of cognitive impairment in normal aging and dementia, Basharat Hussain, Cheng Fang, Junlei Chang, 2021
The tissue origin of human mesenchymal stem cells dictates their therapeutic efficacy on glucose and lipid metabolic disorders in type II diabetic mice, Yinzhong Ma, Lisha Wang, Shilun Yang, Dongyu Liu, Yi Zeng, Lilong Lin, Linhui Qiu, Jiahao Lu, Junlei Chang, Zhihuan Li, 2021
T Cell Response in Ischemic Stroke: From Mechanisms to Translational Insights, Zhang D, Ren J, Luo Y, He Q, Zhao R, Chang J, Yang Y, Guo ZN, 2021
Updates on clinical and genetic heterogeneity of ASPM in 12 autosomal recessive primary microcephaly families in Pakistani population, Niaz Muhammad Khan, Basharat Hussain, Chenqing Zheng, Muhammad Shareef Masoud, Ayaz Khan, Qingquan Gu, Linhui Qiu, Naveed Altaf Malik, Muhammad Qasim, Muhammad Tariq, Junlei Chang, 2021
Normalization of non-canonical Wnt signalings does not compromise blood-brain barrier protection conferred by upregulating endothelial Wnt/β-catenin signaling following ischemic stroke, Ya-Bin Ji, Tian-Xi Wang, Qiang Gao, Xiao-Wen Huang, Junlei Chang, 2021
Trimethylamine N-oxide is associated with coronary atherosclerotic burden in non-ST-segment myocardial infarction patients: SZ-NSTEMI prospective cohort study, Khalid Bin Waleed, Gary Tse, Yong-Kang Lu, Chang-Nong Peng, Hong Tu, Li-Gang Ding, Yun-Long Xia, Shu-Lin Wu, Xin-Tao Li, Hou-Qing Zhou, Qi-Ying Chen, Ai-Mei Sun, Afrasyab Altaf, Junlei Chang, Li-Li Wang, 2021
Lithium alleviates blood-brain barrier breakdown after cerebral ischemia and reperfusion by upregulating endothelial Wnt/β-catenin signaling in mice, Ya-Bin Ji, Qiang Gao, Xi-Xi Tan, Xiao-Wen Huang, Yin-Zhong Ma, Cheng Fang, Sheng-Nan Wang, Lin-Hui Qiu, Yong-Xian Cheng, Fu-You Guo, Junlei Chang, 2021
Peripheral inflammation and blood–brain barrier disruption: effects and mechanisms, Xiaowen Huang, Basharat Hussain, Junlei Chang, 2021
Variants of WNT7A and GPR124 are associated with hemorrhagic transformation following intravenous thrombolysis in ischemic stroke, Song Ta, Xianfang Rong, Zhen-Ni Guo, Hang Jin, Peng Zhang, Fenge Li, Zhihuan Li, Lilong Lin, Chenqing Zheng, Qingquan Gu, Yuan Zhang, Wenlan Liu, Yi Yang, Junlei Chang, 2021
Association of trimethylamine N-oxide with coronary atherosclerotic burden in patients with non-ST-segment elevation myocardial infarction, Bin Waleed K, Lu Y, Liu Q, Zeng F, Tu H, Wei Y, Xu S, Zhang Z, Rongfeng Y, Fan A, Altaf A, Chang JL, Wang L, 2020
Adipocyte fatty acid-binding protein exacerbates cerebral ischaemia injury by disrupting the blood-brain barrier, Liao B, Geng L, Zhang F, Shu L, Wei L, Yeung PKK, Lam KSL, Chung SK, Chang JL, Vanhoutte PM, Xu A, Wang K, Hoo RLC, 2020
Atomic-precision gold clusters for NIR-II imaging, Liu H, Hong G, Luo Z, Chen J, Chang JL, Gong M, He H, Yang J, Yuan X, Li L, Mu X, Wang J, Mi W, Luo J, Xie J, Zhang XD, 2019
The role of G protein-coupled receptor 1 in choriocarcinoma progression, Huang BB, Zhu W, Chang JL, Dai XY, Yu GY, Huang C, Wang E, Li ZH, Lin LL, Wang BB, Chen J, Xiao TX, Niu JM, Zhang J, 2019
Changes in cerebral autoregulation and blood biomarkers after remote ischemic preconditioning, Guo ZN, Guo WT, Liu J, Chang JL, Ma H, Zhang P, Zhang FL, Han K, Hu HH, Jin H, Sun X, Simpson DM, Yang Y
