2003-09--2007-08 PhD: Hong Kong University of Science and Technology
1998-09--2002-08 BSc: Sun Yat-sen University
2021-06~present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Deputy Director of Brain Institute
2021-06~present - Shenzhen-Hong Kong Institute of Brain Science Innovation - Deputy Director
2019-07~2021-05 - Shenzhen-Hong Kong Institute of Brain Science Innovation - Assistant to the Director
2017-04~present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Director of Brain Disease Center
2016-12~2021-05 - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Assistant to the Director of Brain Institute
2015-04~present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Researcher
2010-11~2015-04 - Hong Kong University of Science and Technology - Research Assistant Professor
2009-09~2010-10 - Hong Kong University of Science and Technology - Visiting Scholar
2007-09~2009-08 - Hong Kong University of Science and Technology - Associate Researcher
2021: Major Progress in Chinese Neuroscience
2007: Hong Kong Young Scientist Award (finalist)
Research
Synaptic Basic Research Neurodegenerative Disease Mechanism Research Alzheimer's Disease Biomarkers and Interventions
Gut microbiota-driven metabolic alterations reveal gut–brain communication in Alzheimer’s disease model mice, Yijing Chen, Yinhu Li, Yingying Fan, Shuai Chen, Li Chen, Yuewen Chen, Yu Chen, 2024
Using blood transcriptome analysis for Alzheimer’s disease diagnosis and patient stratification, Huan Zhong, Xiaopu Zhou, Hyebin Uhm, Yuanbing Jiang, Han Cao, Yu Chen, Tiffany T.W. Mak, Ronnie Ming Nok Lo, Bonnie Wing Yan Wong, Elaine Yee Ling Cheng, Kin Y. Mok, Andrew Lung Tat Chan, Timothy C.Y. Kwok, Vincent C.T. Mok, Fanny C.F. Ip, John Hardy, Amy K.Y. Fu, Nancy Y. Ip, 2024
An ultra-compact promoter drives widespread neuronal expression in mouse and monkey brains, Jingyi Wang, Jianbang Lin, Yefei Chen, Jing Liu, Qiongping Zheng, Mao Deng, Ruiqi Wang, Yujing Zhang, Shijing Feng, Zhenyan Xu, Weiyi Ye, Yu Hu, Jiamei Duan, Yunping Lin, Ji Dai, Yu Chen, Yuantao Li, Tao Luo, Qian Chen, Zhonghua Lu, 2023
Non-canonical C-terminal variant of MeCP2 R344W exhibits enhanced degradation rate, Yue Chai, Sharon Shui Ying Lee, Amelle Shillington, Xiaoli Du, Catalina Ka Man Fok, Kam Chun Yeung, Gavin Ka Yu Siu, Shiyang Yuan, Zhongyu Zheng, Hayley Wing Sum Tsang, Shen Gu, Yu Chen, Tao Ye, Jacque Pak Kan Ip, 2023
SASH1: A novel Eph receptor partner and insights into SAM-SAM interactions, Yuzhen Ding, Qiangou Chen, Hui Shan, Jia Liu, Chunyu Lv, Yanhui Wang, Lin Yuan, Yu Chen, Ziyi Wang, Yuxin Yin, Kang Xiao, Jianchao Li, Wei Liu, 2023
Deep learning-based polygenic risk analysis for Alzheimer's disease prediction, Xiaopu Zhou, Yu Chen, Fanny C F Ip, Yuanbing Jiang, Han Cao, Ge Lv, Huan Zhong, Jiahang Chen, Tao Ye, Yuewen Chen, Yulin Zhang, Shuangshuang Ma, Ronnie M N Lo, Estella P S Tong, Vincent C T Mok, Timothy C Y Kwok, Qihao Guo, Kin Y Mok, Maryam Shoai, John Hardy, Lei Chen, Amy K Y Fu, Nancy Y Ip, 2023
Dynamic network modeling of gut microbiota during Alzheimer’s disease progression in mice, Yinhu Li, Yijing Chen, Yingying Fan, Yuewen Chen, Yu Chen, 2023
Generation of a homozygous ABCA7-knockout human iPSC line using the CRISPR/Cas9 system, Mingfeng Guan, Yue Chai, Ran Yi, Yuewen Chen, Jacque P.K. Ip, Tao Ye, Yu Chen, 2022
Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar–Bipolar Transition, Yuewen Chen, Zhenyan Xu, Jing Chen, Yue Qiu, Lin Yuan, Peng Liu, Jing Duan, Li Chen, Yu Chen, 2022
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease, Yuanbing Jiang, Xiaopu Zhou, Hiu Yi Wong, Li Ouyang, Fanny C. F. Ip, Vicky M. N. Chau, Shun-Fat Lau, Wei Wu, Daniel Y. K. Wong, Heukjin Seo, Wing-Yu Fu, Nicole C. H. Lai, Yuewen Chen, Yu Chen, Estella P. S. Tong, Alzheimer’s Disease Neuroimaging Initiative, Vincent C. T. Mok, Timothy C. Y. Kwok, Kin Y. Mok, Maryam Shoai, Benoit Lehallier, Patricia Morán Losada, Eleanor O’Brien, Tenielle Porter, Simon M. Laws, John Hardy, Tony Wyss-Coray, Colin L. Masters, Amy K. Y. Fu, Nancy Y. Ip, 2022
Early Changes in Transcriptomic Profiles in Synaptodendrosomes Reveal Aberrant Synaptic Functions in Alzheimer’s Disease, Xueqi Qu, Li Lin, Wanying Yi, Changyu Sun, Yuewen Chen, Yu Chen, 2022
Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer's Disease Risk, Han Cao, Xiaopu Zhou, Yu Chen, Fanny C F Ip, Yuewen Chen, Nicole C H Lai, Ronnie M N Lo, Estella P S Tong, Vincent C T Mok, Timothy C Y Kwok, Alzheimer’s Disease Neuroimaging Initiative, Amy K Y Fu, Nancy Y Ip, 2022
The East Asian Parkinson Disease Genomics Consortium, Kin Y Mok, East Asian Parkinson Disease Genomics Consortium, 2021
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset, David Goertsen, Nicholas C Flytzanis, Nick Goeden, Miguel R Chuapoco, Alexander Cummins, Yijing Chen, Yingying Fan, Qiangge Zhang, Jitendra Sharma, Yangyang Duan, Liping Wang, Guoping Feng, Yu Chen, Nancy Y Ip, James Pickel, Viviana Gradinaru, 2021
Retinal Dysfunction in Alzheimer's Disease and Implications for Biomarkers, Chunyan Liao, Jinying Xu, Yu Chen, Nancy Y Ip, 2021
Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders, Yijing Chen, Jinying Xu, Yu Chen, 2021
Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice, Yangyang Duan, Tao Ye, Zhe Qu, Yuewen Chen, Abigail Miranda, Xiaopu Zhou, Ka-Chun Lok, Yu Chen, Amy K Y Fu, Viviana Gradinaru, Nancy Y Ip, 2021
Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases, Tao Ye, Yangyang Duan, Hayley W S Tsang, He Xu, Yuewen Chen, Han Cao, Yu Chen, Amy K Y Fu, Nancy Y Ip, 2021
Changes of Regional Neural Activity Homogeneity in Preclinical Alzheimer's Disease: Compensation and Dysfunction, Zhen Zhang, Liang Cui, Yanlu Huang, Yu Chen, Yuehua Li, Qihao Guo, 2021
Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging, Yuanbing Jiang, Xiaopu Zhou, Fanny C Ip, Philip Chan, Yu Chen, Nicole C H Lai, Kit Cheung, Ronnie M N Lo, Estella P S Tong, Bonnie W Y Wong, Andrew L T Chan, Vincent C T Mok, Timothy C Y Kwok, Kin Y Mok, John Hardy, Henrik Zetterberg, Amy K Y Fu, Nancy Y Ip, 2021
p39-associated Cdk5 activity regulates dendritic morphogenesis, Li Ouyang, Yu Chen, Ye Wang, Yuewen Chen, Amy K Y Fu, Wing-Yu Fu, Nancy Y Ip, 2020
Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population, Xiaopu Zhou, Yu Chen, Fanny C F Ip, Nicole C H Lai, Yolanda Y T Li, Yuanbing Jiang, Huan Zhong, Yuewen Chen, Yulin Zhang, Shuangshuang Ma, Ronnie M N Lo, Kit Cheung, Estella P S Tong, Ho Ko, Maryam Shoai, Kin Y Mok, John Hardy, Vincent C T Mok, Timothy C Y Kwok, Amy K Y Fu, Nancy Y Ip, 2020
