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Yan Zhang
Life Science
Peking University
Beijing
Language: English, Chinese
Cell Death
Neurodegeneration
Alzheimer'S Disease
Amyloid
Neuronal Polarity
Biomarkers
Axonal Degeneration
Toxicity
Metabolism
Mechanisms
Areas of Focus
- Mechanisms of cell death in neurodegenerative diseases
- Amyloid toxicity and metabolism in Alzheimer's disease, neuronal polarity, and biomarkers
- Mechanisms of axonal degeneration in Alzheimer's disease
Work Experience
- 2012 - Present, Professor, School of Life Sciences, Peking University
- 2005 - 2012, Associate Professor, School of Life Sciences, Peking University
Academic Background & Achievements
- 1999 - 2003, PhD in Neurology and Neurosurgery, McGill University
- 1997 - 1999, Master of Science in Psychology, Carleton University
- 1993 - 1997, Bachelor of Science in Psychology, Peking University
Publications
- High-performance plasma biomarkers panel for Alzheimer’s disease screening through an femto level label-free biosensing system, Wang S, Deng R, Chen Z-Y, Huang L, Song Y, Yuan D, Li Y, Liu H, Yang F, Fan B, Xu Y, Zhao Z, Li Y, Zhang Y, 2023
- 5-HT6R mull mutation induces synaptic and cognitive defects, Sun Z, Wang B, Chen C, Li C, Zhang Y, 2021
- Structural basis for Draxin-modulated axon guidance and fasciculation by Netrin-1 through DCC, Liu Y, Bhowmick T, Liu Y, Gao X, Mertens HDT, Svergun DI, Xiao J, Zhang Y, Wang J-H, Meijers R, 2018
- Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer’s disease by regulating cilia function, Hu L, Wang B, Zhang Y, 2017
- Structure of unliganded membrane-proximal domains FN4-FN5-FN6 of DCC, Finci L, Zhang J, Sun X, Smock RG, Meijers R, Xiao J, Zhang Y, Wang J-H, 2017
- Selective filtering defect at the axon initial segment in Alzheimer, Sun X, Wu Y, Gu M, Liu Z, Ma Y, Li J, Zhang Y, 2014
- The crystal structure of netrin-1 in complex with DCC reveals the bi-functionality of netrin-1 as a guidance cue, Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HDT, Svergun DI, Zhang Y, Wang J-H, Meijers R, 2014
- MiR-342-5p Decreases Ankyrin G Level in Alzheimer’s Disease Transgenic Mouse Models, Sun X, Wu Y, Gu M, Zhang Y, 2014
- Morphine protects against intracellular amyloid toxicity by inducing estradiol release and upregulation of Hsp70, Cui J, Wang Y, Dong Q, Wu S, Xiao X, Hu J, Chai Z, Zhang Y, 2011
- Tunneling-nanotube development in astrocytes depends on p53 activation, Wang Y, Cui J, Sun X, Zhang Y, 2011
Awards
- 2018: China Young Women Scientist Award
- 2014: National Science Fund for Distinguished Young Scholars
