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张研
Life Science
北京大学
北京
Language: 英语, 汉语
细胞死亡
神经退行性
阿尔茨海默病
淀粉样蛋白
神经元极性
生物标记物
轴突退行性
毒性
代谢
机制
Areas of Focus
- 神经退行性疾病中的细胞死亡机制研究
- 阿尔茨海默病中的淀粉样蛋白毒性和代谢，神经元极性和生物标记物研究
- 阿尔茨海默病中轴突退行性病变的机制
Work Experience
- 2012 - 至今, 教授, 北京大学生命科学学院
- 2005 - 2012, 副教授, 北京大学生命科学学院
Academic Background & Achievements
- 1999 - 2003, 理学博士, 神经内科及神经外科学系, 麦吉尔大学
- 1997 - 1999, 理学硕士, 心理学系, 卡尔顿大学
- 1993 - 1997, 理学学士, 心理学系, 北京大学
Publications
- High-performance plasma biomarkers panel for Alzheimer’s disease screening through an femto level label-free biosensing system, Wang S, Deng R, Chen Z-Y, Huang L, Song Y, Yuan D, Li Y, Liu H, Yang F, Fan B, Xu Y, Zhao Z, Li Y, Zhang Y, 2023
- 5-HT6R mull mutation induces synaptic and cognitive defects, Sun Z, Wang B, Chen C, Li C, Zhang Y, 2021
- Structural basis for Draxin-modulated axon guidance and fasciculation by Netrin-1 through DCC, Liu Y, Bhowmick T, Liu Y, Gao X, Mertens HDT, Svergun DI, Xiao J, Zhang Y, Wang J-H, Meijers R, 2018
- Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer’s disease by regulating cilia function, Hu L, Wang B, Zhang Y, 2017
- Structure of unliganded membrane-proximal domains FN4-FN5-FN6 of DCC, Finci L, Zhang J, Sun X, Smock RG, Meijers R, Xiao J, Zhang Y, Wang J-H, 2017
- Selective filtering defect at the axon initial segment in Alzheimer, Sun X, Wu Y, Gu M, Liu Z, Ma Y, Li J, Zhang Y, 2014
- The crystal structure of netrin-1 in complex with DCC reveals the bi-functionality of netrin-1 as a guidance cue, Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HDT, Svergun DI, Zhang Y, Wang J-H, Meijers R, 2014
- MiR-342-5p Decreases Ankyrin G Level in Alzheimer’s Disease Transgenic Mouse Models, Sun X, Wu Y, Gu M, Zhang Y, 2014
- Morphine protects against intracellular amyloid toxicity by inducing estradiol release and upregulation of Hsp70, Cui J, Wang Y, Dong Q, Wu S, Xiao X, Hu J, Chai Z, Zhang Y, 2011
- Tunneling-nanotube development in astrocytes depends on p53 activation, Wang Y, Cui J, Sun X, Zhang Y, 2011
Awards
- 2018: 中国青年女科学家奖
- 2014: 国家杰出青年基金
