2020-07~Present - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Researcher
2011-10~2020-06 - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Associate Researcher
2008-09~2011-09 - National Toxicology Research Center (USA) - Postdoctoral
2004-09~2007-12 - Shandong University - PhD
2001-09~2004-08 - Shandong University - Master's
1997-09~2001-08 - Shandong University - Bachelor's
Zhejiang Science and Technology Progress Award, First Prize, Provincial Level, 2022
Research
Biochemistry and Molecular Biology Biochemical Engineering
Chemo-Enzymatic Strategy for the Efficient Synthesis of Steroidal Drugs with 10β-Methyl Group and a Side Chain at C17-Position from Biorenewable Phytosterols, Not mentioned, 2024
Reshaping the Substrate Binding Pocket of β-Amino Acid Dehydrogenase for the Synthesis of Aromatic β-Amino Acids, Not mentioned, 2023
The function of steroid terminal monooxygenase in cholesterol or phytosterol degradation by the Mycobacterium neoaurum NRRL B-3805, Not mentioned, 2023
Photoredox/Enzymatic Catalysis Enabling Redox-Neutral Decarboxylative Asymmetric C-C Coupling for Asymmetric Synthesis of Chiral 1,2-Amino Alcohols, Not mentioned, 2023
Desymmetric Reductive Amination of 1,3-Cyclopentadiones to Single Stereoisomer of β-Amino Ketones with an All-Carbon Quaternary Stereocenter by Engineered Amine Dehydrogenases, Not mentioned, 2023
Semirational Engineering of a Thermostable Carbonyl Reductase for the Precision Synthesis of (2R,3R)-2-Methyl-2-benzyl-3-hydroxycyclopentanone and Its Analogues, Not mentioned, 2023
Engineering a Carbonyl Reductase for Scalable Preparation of (S)-3-Cyclopentyl-3-hydroxypropanenitrile, the Key Building Block of Ruxolitinib, Not mentioned, 2022
Biotransformation Enables Innovations Toward Green Synthesis of Steroidal Pharmaceuticals, Not mentioned, 2022
Effects of the 3-ketosteroid-Δ1-dehydrogenase on phytosterol transformation with the accumulation of 9α-hydroxyandrost-4-ene-3,17-dione by Mycobacterium smegmatis, Not mentioned, 2020
Crystal structures and substrate recognition mechanism of 2, 3-dihydroxybenzoic acid decarboxylase from Fusarium oxysporum, Not mentioned, 2020
Structure-Guided Directed Evolution of a Carbonyl Reductase Enables the Stereoselective Synthesis of (2S,3S)-2,2-Disubstituted-3-hydroxycyclopentanones via Desymmetric Reduction, Not mentioned, 2020
Mutation of a key amino acid residue of meso-diaminopimelate dehydrogenase enhances the catalytic activity toward alkyl substituted 2-keto acids, Not mentioned, 2020
Biocatalytic Access to 1,4-Diazepanes via Imine Reductase-Catalyzed Intramolecular Asymmetric Reductive Amination, Not mentioned, 2020
Adaptive laboratory evolution enhances methanol tolerance and conversion in engineered Corynebacterium glutamicum, Not mentioned, 2020
Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase, Not mentioned, 2019
Improving and Inverting C-beta-Stereoselectivity of Threonine Aldolase via Substrate-Binding-Guided Mutagenesis and a Stepwise Visual Screening, Not mentioned, 2019
Flavin Oxidoreductase-Mediated Regeneration of Nicotinamide Adenine Dinucleotide with Dioxygen and Catalytic Amount of Flavin Mononucleotide for One-Pot Multi-Enzymatic Preparation of Ursodeoxycholic Acid, Not mentioned, 2019
Improving the catalytic efficiency and stereoselectivity of a nitrilase from Synechocystis sp. PCC6803 by semi-rational engineering en route to chiral gamma-amino acids, Not mentioned, 2019
Efficient microbial synthesis of key steroidal intermediates from bio-renewable phytosterols by genetically modified Mycobacterium fortuitum strains, Not mentioned, 2019
Distinct Regioselectivity of Fungal P450 Enzymes for Steroidal Hydroxylation, Not mentioned, 2019
Growth-coupled evolution of phosphoketolase to improve l-glutamate production by Corynebacterium glutamicum, Not mentioned, 2019
New product identification in the sterol metabolism by an industrial strain Mycobacterium neoaurum NRRL B-3805, Not mentioned, 2018
A Fungal P450 Enzyme from Thanatephorus cucumeris with Steroid Hydroxylation Capabilities, Not mentioned, 2018
Structure-guided engineering of meso-diaminopimelate dehydrogenase for enantioselective reductive amination of sterically bulky 2-keto acids, Not mentioned, 2018
Accessing d-Valine Synthesis by Improved Variants of Bacterial Cyclohexylamine Oxidase, Not mentioned, 2018
Molecular Basis for the High Activity and Enantioselectivity of the Carbonyl Reductase from Sporobolomyces salmonicolor toward alpha-Haloacetophenones, Not mentioned, 2018
Biocatalytic Route to Chiral 2-Substituted-1,2,3,4-Tetrahydroquinolines Using Cyclohexylamine Oxidase Muteins, Not mentioned, 2018
Optimizing of L-aspartic acid production by a 'one-pot two-enzyme' process, Not mentioned, 2017
Characterization of new recombinant 3-ketosteroid - Δ1- dehydrogenases for the biotransformation of steroids, Not mentioned, 2017
A new D-threonine aldolase as a promising biocatalyst for highly stereoselective preparation of chiral aromatic beta-hydroxy-alpha-amino acids, Not mentioned, 2017
Highly Atom Economic Synthesis of d-2-Aminobutyric Acid through an In-Vitro Tri-enzymatic Catalytic System, Not mentioned, 2017
Characterization of new recombinant 3-ketosteroid-Delta(1)-dehydrogenases for the biotransformation of steroids, Not mentioned, 2017
Effect of smokeless tobacco products on human oral bacteria growth and viability, Not mentioned, 2016
Process optimization for enzymatic synthesis of cis-cefprozil by a mutant penicillin G acylase, Not mentioned, 2016
Asymmetric enzymatic reduction of quinuclidinone to (S)-3-quinuclidinol, Not mentioned, 2016
A sialic acid aldolase from Peptoclostridium difficile NAP08 with 4-hydroxy-2-oxo-pentanoate aldolase activity, Not mentioned, 2016
Expression and characterization of a novel ω-transaminase from Burkholderia phytofirmans PsJN, Not mentioned, 2016
Optimization of the transformation conditions for the 19-hydroxylation of cortexolone by Thanatephorus cucumeris, Not mentioned, 2016
Semi-Rational Engineering a Carbonyl Reductase for the Enantioselective Reduction of beta-Amino Ketones, Not mentioned, 2015
Expression and characterization of a novel halohydrin dehalogenase from Tistrella mobilis KA081020-065, Not mentioned, 2015
Effect of residue Y76 on co-enzyme specificity of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum, Not mentioned, 2015
High throughput screening of active and stereoselective carbonyl reductases, Not mentioned, 2015
Highly Efficient Synthesis of Optically Pure (S)-1-phenyl-1,2-ethanediol by a Self-Sufficient Whole Cell Biocatalyst, Not mentioned, 2015
Combining sites related to autoproteolytic cleavage and activity to improve the deacylation activity of cephalosporin C acylase, Not mentioned, 2015
Substrate profile of an ω-transaminase from Burkholderia vietnamiensis and its potential for the production of optically pure amines and unnatural amino acids, Not mentioned, 2014
