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Jinhui Feng
Life Science
University of Chinese Academy of Sciences
Tianjin
Language: Chinese, English
Biochemistry
Molecular Biology
Biochemical Engineering
Enzymes
Biocatalysis
Microbial Metabolism
Steroidal Drugs
Phytosterols
Enzyme Engineering
Green Synthesis
Areas of Focus
- Biochemistry and Molecular Biology
- Biochemical Engineering
Work Experience
- 2020-07~Present - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Researcher
- 2011-10~2020-06 - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Associate Researcher
- 2008-09~2011-09 - National Toxicology Research Center (USA) - Postdoctoral
- 2004-09~2007-12 - Shandong University - PhD
- 2001-09~2004-08 - Shandong University - Master's
- 1997-09~2001-08 - Shandong University - Bachelor's
Academic Background & Achievements
- 2004-09--2007-12 PhD: Shandong University
- 2001-09--2004-08 Master's: Shandong University
- 1997-09--2001-08 Bachelor's: Shandong University
Publications
- Chemo-Enzymatic Strategy for the Efficient Synthesis of Steroidal Drugs with 10β-Methyl Group and a Side Chain at C17-Position from Biorenewable Phytosterols, Not mentioned, 2024
- Reshaping the Substrate Binding Pocket of β-Amino Acid Dehydrogenase for the Synthesis of Aromatic β-Amino Acids, Not mentioned, 2023
- The function of steroid terminal monooxygenase in cholesterol or phytosterol degradation by the Mycobacterium neoaurum NRRL B-3805, Not mentioned, 2023
- Photoredox/Enzymatic Catalysis Enabling Redox-Neutral Decarboxylative Asymmetric C-C Coupling for Asymmetric Synthesis of Chiral 1,2-Amino Alcohols, Not mentioned, 2023
- Desymmetric Reductive Amination of 1,3-Cyclopentadiones to Single Stereoisomer of β-Amino Ketones with an All-Carbon Quaternary Stereocenter by Engineered Amine Dehydrogenases, Not mentioned, 2023
- Semirational Engineering of a Thermostable Carbonyl Reductase for the Precision Synthesis of (2R,3R)-2-Methyl-2-benzyl-3-hydroxycyclopentanone and Its Analogues, Not mentioned, 2023
- Engineering a Carbonyl Reductase for Scalable Preparation of (S)-3-Cyclopentyl-3-hydroxypropanenitrile, the Key Building Block of Ruxolitinib, Not mentioned, 2022
- Biotransformation Enables Innovations Toward Green Synthesis of Steroidal Pharmaceuticals, Not mentioned, 2022
- Effects of the 3-ketosteroid-Δ1-dehydrogenase on phytosterol transformation with the accumulation of 9α-hydroxyandrost-4-ene-3,17-dione by Mycobacterium smegmatis, Not mentioned, 2020
- Crystal structures and substrate recognition mechanism of 2, 3-dihydroxybenzoic acid decarboxylase from Fusarium oxysporum, Not mentioned, 2020
- Structure-Guided Directed Evolution of a Carbonyl Reductase Enables the Stereoselective Synthesis of (2S,3S)-2,2-Disubstituted-3-hydroxycyclopentanones via Desymmetric Reduction, Not mentioned, 2020
- Mutation of a key amino acid residue of meso-diaminopimelate dehydrogenase enhances the catalytic activity toward alkyl substituted 2-keto acids, Not mentioned, 2020
- Biocatalytic Access to 1,4-Diazepanes via Imine Reductase-Catalyzed Intramolecular Asymmetric Reductive Amination, Not mentioned, 2020
- Adaptive laboratory evolution enhances methanol tolerance and conversion in engineered Corynebacterium glutamicum, Not mentioned, 2020
- Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase, Not mentioned, 2019
- Improving and Inverting C-beta-Stereoselectivity of Threonine Aldolase via Substrate-Binding-Guided Mutagenesis and a Stepwise Visual Screening, Not mentioned, 2019
- Flavin Oxidoreductase-Mediated Regeneration of Nicotinamide Adenine Dinucleotide with Dioxygen and Catalytic Amount of Flavin Mononucleotide for One-Pot Multi-Enzymatic Preparation of Ursodeoxycholic Acid, Not mentioned, 2019
- Improving the catalytic efficiency and stereoselectivity of a nitrilase from Synechocystis sp. PCC6803 by semi-rational engineering en route to chiral gamma-amino acids, Not mentioned, 2019
- Efficient microbial synthesis of key steroidal intermediates from bio-renewable phytosterols by genetically modified Mycobacterium fortuitum strains, Not mentioned, 2019
- Distinct Regioselectivity of Fungal P450 Enzymes for Steroidal Hydroxylation, Not mentioned, 2019
- Growth-coupled evolution of phosphoketolase to improve l-glutamate production by Corynebacterium glutamicum, Not mentioned, 2019
- New product identification in the sterol metabolism by an industrial strain Mycobacterium neoaurum NRRL B-3805, Not mentioned, 2018
- A Fungal P450 Enzyme from Thanatephorus cucumeris with Steroid Hydroxylation Capabilities, Not mentioned, 2018
- Structure-guided engineering of meso-diaminopimelate dehydrogenase for enantioselective reductive amination of sterically bulky 2-keto acids, Not mentioned, 2018
- Accessing d-Valine Synthesis by Improved Variants of Bacterial Cyclohexylamine Oxidase, Not mentioned, 2018
- Molecular Basis for the High Activity and Enantioselectivity of the Carbonyl Reductase from Sporobolomyces salmonicolor toward alpha-Haloacetophenones, Not mentioned, 2018
- Biocatalytic Route to Chiral 2-Substituted-1,2,3,4-Tetrahydroquinolines Using Cyclohexylamine Oxidase Muteins, Not mentioned, 2018
- Optimizing of L-aspartic acid production by a 'one-pot two-enzyme' process, Not mentioned, 2017
- Characterization of new recombinant 3-ketosteroid - Δ1- dehydrogenases for the biotransformation of steroids, Not mentioned, 2017
- A new D-threonine aldolase as a promising biocatalyst for highly stereoselective preparation of chiral aromatic beta-hydroxy-alpha-amino acids, Not mentioned, 2017
- Highly Atom Economic Synthesis of d-2-Aminobutyric Acid through an In-Vitro Tri-enzymatic Catalytic System, Not mentioned, 2017
- Characterization of new recombinant 3-ketosteroid-Delta(1)-dehydrogenases for the biotransformation of steroids, Not mentioned, 2017
- Effect of smokeless tobacco products on human oral bacteria growth and viability, Not mentioned, 2016
- Process optimization for enzymatic synthesis of cis-cefprozil by a mutant penicillin G acylase, Not mentioned, 2016
- Asymmetric enzymatic reduction of quinuclidinone to (S)-3-quinuclidinol, Not mentioned, 2016
- A sialic acid aldolase from Peptoclostridium difficile NAP08 with 4-hydroxy-2-oxo-pentanoate aldolase activity, Not mentioned, 2016
- Expression and characterization of a novel ω-transaminase from Burkholderia phytofirmans PsJN, Not mentioned, 2016
- Optimization of the transformation conditions for the 19-hydroxylation of cortexolone by Thanatephorus cucumeris, Not mentioned, 2016
- Semi-Rational Engineering a Carbonyl Reductase for the Enantioselective Reduction of beta-Amino Ketones, Not mentioned, 2015
- Expression and characterization of a novel halohydrin dehalogenase from Tistrella mobilis KA081020-065, Not mentioned, 2015
- Effect of residue Y76 on co-enzyme specificity of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum, Not mentioned, 2015
- High throughput screening of active and stereoselective carbonyl reductases, Not mentioned, 2015
- Highly Efficient Synthesis of Optically Pure (S)-1-phenyl-1,2-ethanediol by a Self-Sufficient Whole Cell Biocatalyst, Not mentioned, 2015
- Combining sites related to autoproteolytic cleavage and activity to improve the deacylation activity of cephalosporin C acylase, Not mentioned, 2015
- Substrate profile of an ω-transaminase from Burkholderia vietnamiensis and its potential for the production of optically pure amines and unnatural amino acids, Not mentioned, 2014
- Substrate profile of an omega-transaminase
Awards
- Zhejiang Science and Technology Progress Award, First Prize, Provincial Level, 2022
