Upload Avatar (500 x 500)
Yao-Xi He
Life Science
University of Chinese Academy of Sciences
Yunnan
Language: Chinese, English
Evolution
Adaptation
Genomics
Diversity
Human
Genetic
Phenotype
Tibetans
High-Altitude
Research
Areas of Focus
- Human adaptive evolution
- Genomic diversity
Academic Background & Achievements
- 2014-09 to 2019-06 Ph.D. in Science: University of Chinese Academy of Sciences
- 2010-09 to 2014-07 Bachelor's in Science: Yunnan University
Publications
- High Arterial Oxygen Saturation in the Acclimatized Lowlanders Living at High Altitude, First Author, 2023
- Large-scale genome sequencing redefines the genetic footprints of high-altitude adaptation in Tibetans, Second Author, 2023
- Deep phenotyping of 11,880 highlanders reveals novel adaptive traits in native Tibetans, Corresponding Author, 2023
- Polygenic adaptation leads to a higher reproductive fitness of native Tibetans at high altitude, Corresponding Author, 2023
- Exploring the primate genome: Unraveling the mysteries of evolution and human disease, First Author, 2023
- Heritability enrichment in context-specific regulatory networks improves phenotype-relevant tissue identification, Fifth Author, 2022
- Genetic adaptation of skin pigmentation in highland Tibetans, Collaborative Author, 2022
- A Late Pleistocene human genome from Southwest China, Corresponding Author, 2022
- Seasonality and Sex-Biased Fluctuation of Birth Weight in Tibetan Populations, First Author, 2021
- Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation, Third Author, 2020
- Association study of genomic structural variants with high-altitude adaptation phenotypes in Tibetans, Second Author, 2020
- Phenotypic and Genetic Study on High-altitude Adaptation of Tibetan Populations, First Author, 2019
- Long-read assembly of the Chinese rhesus macaque genome and identification of ape-specific structural variants, First Author, 2019
- The Transcriptomic Landscape of Yaks Reveals Molecular Pathways for High Altitude Adaptation, Third Author, 2019
- Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys, Second Author, 2019
- Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia, First Author, 2018
- EP300 contributes to high-altitude adaptation in Tibetans by regulating nitric oxide production, Second Author, 2017
- GCH1 plays a role in the high-altitude adaptation of Tibetans, Second Author, 2017
- Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia, Third Author, 2017
- Cross-altitude analysis suggests a turning point at the elevation of 4,500m for polycythemia prevalence in tibetans., Second Author, 2017
- HMOX2 Functions as a Modifier Gene for High-Altitude Adaptation in Tibetans, Ninth Author, 2016
