Professor | Lijian Hui | Asia Growth Partners

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Name	Lijian Hui
Contact Information	huilab@sibcb.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Lijian Hui

Contact Information

huilab@sibcb.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1998-09--2003-08 PhD: Shanghai Institute of Cell Biology, Chinese Academy of Sciences 1992-09--1997-08 Bachelor's: Department of Biology, University of Science and Technology of China
Work Experience	2008-09~2011-07 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher 2004-08~2008-08 - Institute of Molecular Pathology (IMP), Vienna, Austria - Postdoctoral Researcher 1998-09~2003-08 - Shanghai Institute of Cell Biology, Chinese Academy of Sciences - PhD Student 1992-09~1997-08 - Department of Biology, University of Science and Technology of China - Bachelor's Student

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1998-09--2003-08 PhD: Shanghai Institute of Cell Biology, Chinese Academy of Sciences
1992-09--1997-08 Bachelor's: Department of Biology, University of Science and Technology of China

Work Experience

2008-09~2011-07 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher
2004-08~2008-08 - Institute of Molecular Pathology (IMP), Vienna, Austria - Postdoctoral Researcher
1998-09~2003-08 - Shanghai Institute of Cell Biology, Chinese Academy of Sciences - PhD Student
1992-09~1997-08 - Department of Biology, University of Science and Technology of China - Bachelor's Student

Areas of Focus	Molecular Pathological Mechanisms of Liver Diseases
Publications	Applications of liver organoids, Lijian Hui, 2023 A Pharmacogenomic Landscape in Human Liver Cancers, Lijian Hui, 2020 A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling, Lijian Hui, 2020 A Pharmacogenomic Landscape in Human Liver Cancers, Lijian Hui, 2019 A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling, Lijian Hui, 2019 Modeling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes., Lijian Hui, 2019 Arid1a regulates response to anti-angiogenic therapy in advanced hepatocellular carcinoma, Lijian Hui, 2018 High-throughput screening for Survivin and Borealin interaction inhibitors in hepatocellular carcinoma, Lijian Hui, 2017 Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, Lijian Hui, 2017 Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening, Lijian Hui, 2017 Hepatocellular carcinoma repression by TNFa-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization, Lijian Hui, 2016 Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes, Lijian Hui, 2016 Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers, Lijian Hui, 2016 Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I, Lijian Hui, 2016 DUSP16 ablation arrests the cell cycle and induces cellular senescence, Lijian Hui, 2015 miR-27b synergizes with anticancer drugs via p53 activation and CYP1B1 suppression, Lijian Hui, 2015 Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes, Lijian Hui, 2014 Hepatic Loss of Survivin Impairs Postnatal Liver Development and Promotes Expansion of Hepatic Progenitor Cells in Mice, Lijian Hui, 2013 Cell fate conversion: Direct induction of hepatocyte-like cells from fibroblasts, Lijian Hui, 2013 Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin, Lijian Hui, 2012 p38 alpha controls erythroblast enucleation and Rb signaling in stress erythropoiesis, Lijian Hui, 2012 Mitogen-activated protein kinases in hepatocellular carcinoma development, Lijian Hui, 2011 Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors, Lijian Hui, 2011 Hepatoblast-Like Progenitor Cells Derived From Embryonic Stem Cells Can Repopulate Livers of Mice, Lijian Hui, 2010 Antagonistic control of cell fates by JNK and p38-MAPK signaling, Lijian Hui, 2008 p38 alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway, Lijian Hui, 2007 p38alpha: a suppressor of cell proliferation and tumorigenesis, Lijian Hui, 2007 Identification of Alternatively Spliced mRNA Isoforms Associated with Cancers by Genome-wide ESTs Alignment, Lijian Hui, 2004 Hepatic Loss of Borealin Impairs Postnatal Liver Development, Regeneration, and Hepatocarcinogenesis, Lijian Hui Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation, Lijian Hui

Areas of Focus

Molecular Pathological Mechanisms of Liver Diseases

Publications

Applications of liver organoids, Lijian Hui, 2023
A Pharmacogenomic Landscape in Human Liver Cancers, Lijian Hui, 2020
A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling, Lijian Hui, 2020
A Pharmacogenomic Landscape in Human Liver Cancers, Lijian Hui, 2019
A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling, Lijian Hui, 2019
Modeling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes., Lijian Hui, 2019
Arid1a regulates response to anti-angiogenic therapy in advanced hepatocellular carcinoma, Lijian Hui, 2018
High-throughput screening for Survivin and Borealin interaction inhibitors in hepatocellular carcinoma, Lijian Hui, 2017
Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, Lijian Hui, 2017
Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening, Lijian Hui, 2017
Hepatocellular carcinoma repression by TNFa-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization, Lijian Hui, 2016
Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes, Lijian Hui, 2016
Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers, Lijian Hui, 2016
Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I, Lijian Hui, 2016
DUSP16 ablation arrests the cell cycle and induces cellular senescence, Lijian Hui, 2015
miR-27b synergizes with anticancer drugs via p53 activation and CYP1B1 suppression, Lijian Hui, 2015
Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes, Lijian Hui, 2014
Hepatic Loss of Survivin Impairs Postnatal Liver Development and Promotes Expansion of Hepatic Progenitor Cells in Mice, Lijian Hui, 2013
Cell fate conversion: Direct induction of hepatocyte-like cells from fibroblasts, Lijian Hui, 2013
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin, Lijian Hui, 2012
p38 alpha controls erythroblast enucleation and Rb signaling in stress erythropoiesis, Lijian Hui, 2012
Mitogen-activated protein kinases in hepatocellular carcinoma development, Lijian Hui, 2011
Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors, Lijian Hui, 2011
Hepatoblast-Like Progenitor Cells Derived From Embryonic Stem Cells Can Repopulate Livers of Mice, Lijian Hui, 2010
Antagonistic control of cell fates by JNK and p38-MAPK signaling, Lijian Hui, 2008
p38 alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway, Lijian Hui, 2007
p38alpha: a suppressor of cell proliferation and tumorigenesis, Lijian Hui, 2007
Identification of Alternatively Spliced mRNA Isoforms Associated with Cancers by Genome-wide ESTs Alignment, Lijian Hui, 2004
Hepatic Loss of Borealin Impairs Postnatal Liver Development, Regeneration, and Hepatocarcinogenesis, Lijian Hui
Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation, Lijian Hui

Liver Diseases Molecular Pathology Mechanisms Hepatocyte Regeneration Cell Biology Research Medicine

Xiling Du - Tongji University

Jian Qiu - Central South University

Tan Jieqiong - Central South University

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