Professor | 惠利健 | 数字化转型顾问

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Name	惠利健
Contact Information	huilab@sibcb.ac.cn
Language ability	中文, 英语
Province	上海

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Name

惠利健

Contact Information

huilab@sibcb.ac.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	1998-09--2003-08 博士: 中国科学院上海生命科学院上海细胞研究所 1992-09--1997-08 学士: 中国科学技术大学生物系
Work Experience	2008-09~2011-07 - 中国科学院上海生命科学院上海生物化学和细胞研究所 - 研究员 2004-08~2008-08 - 奥地利维也纳Institute of Molecular Pathology (IMP) - 博士后 1998-09~2003-08 - 中国科学院上海生命科学院上海细胞研究所 - 博士 1992-09~1997-08 - 中国科学技术大学生物系 - 学士

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

1998-09--2003-08 博士: 中国科学院上海生命科学院上海细胞研究所
1992-09--1997-08 学士: 中国科学技术大学生物系

Work Experience

2008-09~2011-07 - 中国科学院上海生命科学院上海生物化学和细胞研究所 - 研究员
2004-08~2008-08 - 奥地利维也纳Institute of Molecular Pathology (IMP) - 博士后
1998-09~2003-08 - 中国科学院上海生命科学院上海细胞研究所 - 博士
1992-09~1997-08 - 中国科学技术大学生物系 - 学士

Areas of Focus	肝脏疾病的分子病理机制
Publications	肝脏类器官的应用, 惠利健, 2023 肝癌细胞模型库及其药物基因组学“蓝图”, 惠利健, 2020 一种由Arid1a蛋白介导的染色体可及性状态调控肝细胞对肝损伤相关的YAP信号的响应, 惠利健, 2020 A Pharmacogenomic Landscape in Human Liver Cancers, 惠利健, 2019 A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling, 惠利健, 2019 Modeling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes., 惠利健, 2019 Arid1a regulates response to anti-angiogenic therapy in advanced hepatocellular carcinoma, 惠利健, 2018 High-throughput screening for Survivin and Borealin interaction inhibitors in hepatocellular carcinoma, 惠利健, 2017 Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, 惠利健, 2017 Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening, 惠利健, 2017 Hepatocellular carcinoma repression by TNFa-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization, 惠利健, 2016 Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes, 惠利健, 2016 Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers, 惠利健, 2016 Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I, 惠利健, 2016 DUSP16 ablation arrests the cell cycle and induces cellular senescence, 惠利健, 2015 miR-27b在抗肿瘤耐药中的应用, 惠利健, 2015 Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes, 惠利健, 2014 Hepatic Loss of Survivin Impairs Postnatal Liver Development and Promotes Expansion of Hepatic Progenitor Cells in Mice, 惠利健, 2013 Cell fate conversion: Direct induction of hepatocyte-like cells from fibroblasts, 惠利健, 2013 Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin, 惠利健, 2012 p38 alpha controls erythroblast enucleation and Rb signaling in stress erythropoiesis, 惠利健, 2012 Mitogen-activated protein kinases in hepatocellular carcinoma development, 惠利健, 2011 Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors, 惠利健, 2011 Hepatoblast-Like Progenitor Cells Derived From Embryonic Stem Cells Can Repopulate Livers of Mice, 惠利健, 2010 Antagonistic control of cell fates by JNK and p38-MAPK signaling, 惠利健, 2008 p38 alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway, 惠利健, 2007 p38alpha: a suppressor of cell proliferation and tumorigenesis, 惠利健, 2007 Identification of Alternatively Spliced mRNA

Areas of Focus

肝脏疾病的分子病理机制

Publications

肝脏类器官的应用, 惠利健, 2023
肝癌细胞模型库及其药物基因组学“蓝图”, 惠利健, 2020
一种由Arid1a蛋白介导的染色体可及性状态调控肝细胞对肝损伤相关的YAP信号的响应, 惠利健, 2020
A Pharmacogenomic Landscape in Human Liver Cancers, 惠利健, 2019
A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling, 惠利健, 2019
Modeling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes., 惠利健, 2019
Arid1a regulates response to anti-angiogenic therapy in advanced hepatocellular carcinoma, 惠利健, 2018
High-throughput screening for Survivin and Borealin interaction inhibitors in hepatocellular carcinoma, 惠利健, 2017
Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, 惠利健, 2017
Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening, 惠利健, 2017
Hepatocellular carcinoma repression by TNFa-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization, 惠利健, 2016
Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes, 惠利健, 2016
Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers, 惠利健, 2016
Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I, 惠利健, 2016
DUSP16 ablation arrests the cell cycle and induces cellular senescence, 惠利健, 2015
miR-27b在抗肿瘤耐药中的应用, 惠利健, 2015
Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes, 惠利健, 2014
Hepatic Loss of Survivin Impairs Postnatal Liver Development and Promotes Expansion of Hepatic Progenitor Cells in Mice, 惠利健, 2013
Cell fate conversion: Direct induction of hepatocyte-like cells from fibroblasts, 惠利健, 2013
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin, 惠利健, 2012
p38 alpha controls erythroblast enucleation and Rb signaling in stress erythropoiesis, 惠利健, 2012
Mitogen-activated protein kinases in hepatocellular carcinoma development, 惠利健, 2011
Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors, 惠利健, 2011
Hepatoblast-Like Progenitor Cells Derived From Embryonic Stem Cells Can Repopulate Livers of Mice, 惠利健, 2010
Antagonistic control of cell fates by JNK and p38-MAPK signaling, 惠利健, 2008
p38 alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway, 惠利健, 2007
p38alpha: a suppressor of cell proliferation and tumorigenesis, 惠利健, 2007
Identification of Alternatively Spliced mRNA

肝脏疾病分子病理机制肝细胞再生细胞生物学研究医学

王海芸 - 同济大学

Area of Focus
肿瘤 | 异质性 | 精准 | 用药 | 联合 | 癌症 | 生物标志物 | 新型 | 研究 | 分子

余勇 - 同济大学

陈平 - 同济大学

Area of Focus
表观遗传学 | 癌症 | 非编码Rna | 干细胞 | 定向分化 | 胚胎干细胞 | 肝脏组织细胞 | 机制 | 应用 | 研究

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