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惠利健
Life Science
中国科学院大学
上海
Language: 中文, 英语
肝脏
疾病
分子
病理
机制
肝细胞
再生
细胞生物学
研究
医学
Areas of Focus
- 肝脏疾病的分子病理机制
Work Experience
- 2008-09~2011-07 - 中国科学院上海生命科学院上海生物化学和细胞研究所 - 研究员
- 2004-08~2008-08 - 奥地利维也纳Institute of Molecular Pathology (IMP) - 博士后
- 1998-09~2003-08 - 中国科学院上海生命科学院上海细胞研究所 - 博士
- 1992-09~1997-08 - 中国科学技术大学生物系 - 学士
Academic Background & Achievements
- 1998-09--2003-08 博士: 中国科学院上海生命科学院上海细胞研究所
- 1992-09--1997-08 学士: 中国科学技术大学生物系
Publications
- 肝脏类器官的应用, 惠利健, 2023
- 肝癌细胞模型库及其药物基因组学“蓝图”, 惠利健, 2020
- 一种由Arid1a蛋白介导的染色体可及性状态调控肝细胞对肝损伤相关的YAP信号的响应, 惠利健, 2020
- A Pharmacogenomic Landscape in Human Liver Cancers, 惠利健, 2019
- A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling, 惠利健, 2019
- Modeling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes., 惠利健, 2019
- Arid1a regulates response to anti-angiogenic therapy in advanced hepatocellular carcinoma, 惠利健, 2018
- High-throughput screening for Survivin and Borealin interaction inhibitors in hepatocellular carcinoma, 惠利健, 2017
- Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, 惠利健, 2017
- Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening, 惠利健, 2017
- Hepatocellular carcinoma repression by TNFa-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization, 惠利健, 2016
- Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes, 惠利健, 2016
- Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers, 惠利健, 2016
- Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I, 惠利健, 2016
- DUSP16 ablation arrests the cell cycle and induces cellular senescence, 惠利健, 2015
- miR-27b在抗肿瘤耐药中的应用, 惠利健, 2015
- Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes, 惠利健, 2014
- Hepatic Loss of Survivin Impairs Postnatal Liver Development and Promotes Expansion of Hepatic Progenitor Cells in Mice, 惠利健, 2013
- Cell fate conversion: Direct induction of hepatocyte-like cells from fibroblasts, 惠利健, 2013
- Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin, 惠利健, 2012
- p38 alpha controls erythroblast enucleation and Rb signaling in stress erythropoiesis, 惠利健, 2012
- Mitogen-activated protein kinases in hepatocellular carcinoma development, 惠利健, 2011
- Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors, 惠利健, 2011
- Hepatoblast-Like Progenitor Cells Derived From Embryonic Stem Cells Can Repopulate Livers of Mice, 惠利健, 2010
- Antagonistic control of cell fates by JNK and p38-MAPK signaling, 惠利健, 2008
- p38 alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway, 惠利健, 2007
- p38alpha: a suppressor of cell proliferation and tumorigenesis, 惠利健, 2007
- Identification of Alternatively Spliced mRNA
