Areas of Focus
- Regulation and function of mRNA splicing in mammalian cells
Work Experience
- 2008-06~Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Research Group Leader
- 2006-11~2008-05 - Friedrich-Alexander-Universität Erlangen-Nürnberg - Postdoctoral Researcher
- 2003-06~2006-10 - Justus Liebig University Giessen - Postdoctoral Researcher
Academic Background & Achievements
- 1999-09--2003-05 PhD: Justus Liebig University Giessen
- 1998-08--1999-08 Master's: Free University of Berlin
- 1989-09--1993-07 Bachelor's: Fudan University
Publications
- Upregulated YB-1 protein promotes glioblastoma growth through a YB-1/CCT4/mLST8/mTOR pathway, Corresponding Author, 2022
- 5 ' UTR SNP of FGF13 causes translational defect and intellectual disability, Corresponding Author, 2021
- Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes, 4th Author, 2021
- Msi2-mediated MiR7a-1 processing repression promotes myogenesis, Corresponding Author, 2021
- Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models, Corresponding Author, 2021
- QKI-5 regulates the alternative splicing of cytoskeletal gene ADD3 in lung cancer, Corresponding Author, 2021
- LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice, 13th Author, 2020
- Auto-regulatory feedback by RNA-binding proteins, 3rd Author, 2019
- Crystal structure of a Y-box binding protein 1 (YB-1)–RNA complex reveals key features and residues interacting with RNA, Corresponding Author, 2019
- Opposing roles of mir-294 and mbnl1/2 in shaping the gene regulatory network of embryonic stem cells, Corresponding Author, 2018
- SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling, Corresponding Author, 2017
- The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis, 21st Author, 2017
- Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis, 5th Author, 2017
- QKI5-mediated alternative splicing of the histone variant macroH2A1 regulates gastric carcinogenesis, 5th Author, 2016
- Genome-wide analysis of YB-1-RNA interactions reveals a novel role of YB-1 in miRNA processing in glioblastoma multiforme, Corresponding Author, 2015
- The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing, 11th Author, 2014
- YB-1 binds to CAUC motifs and stimulates exon inclusion by enhancing the recruitment of U2AF to weak polypyrimidine tracts, Corresponding Author, 2012
- HnRNP L-mediated regulation of mammalian alternative splicing by interference with splice site recognition, 2nd Author, 2010
- The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing, 3rd Author, 2010
- Auto- and Cross-Regulation of the hnRNP L Proteins by Alternative Splicing ▿ ‡, 6th Author, 2009
- Diverse roles of hnRNP L in mammalian mRNA processing: A combined microarray and RNAi analysis, 3rd Author, 2008
- HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats, Not mentioned, 2003
- Novel function role of CA repeats and hnRNP L in RNA stability, 1st Author, 2003
- Intronic CA-repeat and CA-rich elements: a new class of regulators of mammalian alternative splicing, 11th Author
