Professor | 惠静毅 | 数字化转型顾问

Name	惠静毅
Contact Information	jyhui@sibs.ac.cn
Language ability	英语, 德语, 中文
Province	上海

Name

惠静毅

Contact Information

jyhui@sibs.ac.cn

Language ability

英语, 德语, 中文

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	1999-09--2003-05 博士: 德国尤斯图斯-李比希-吉森大学 1998-08--1999-08 硕士: 德国柏林自由大学 1989-09--1993-07 学士: 上海复旦大学
Work Experience	2008-06~现在 - 中科院上海生命科学研究院生化细胞所 - 研究组长 2006-11~2008-05 - 德国弗里德利希-亚力山大-埃尔兰根纽伦堡大学 - 博士后 2003-06~2006-10 - 德国尤斯图斯-李比希-吉森大学 - 博士后

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

1999-09--2003-05 博士: 德国尤斯图斯-李比希-吉森大学
1998-08--1999-08 硕士: 德国柏林自由大学
1989-09--1993-07 学士: 上海复旦大学

Work Experience

2008-06~现在 - 中科院上海生命科学研究院生化细胞所 - 研究组长
2006-11~2008-05 - 德国弗里德利希-亚力山大-埃尔兰根纽伦堡大学 - 博士后
2003-06~2006-10 - 德国尤斯图斯-李比希-吉森大学 - 博士后

Areas of Focus	哺乳动物细胞mRNA剪接的调控与功能
Publications	Upregulated YB-1 protein promotes glioblastoma growth through a YB-1/CCT4/mLST8/mTOR pathway, 通讯作者, 2022 5 ' UTR SNP of FGF13 causes translational defect and intellectual disability, 通讯作者, 2021 Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes, 第4作者, 2021 Msi2-mediated MiR7a-1 processing repression promotes myogenesis, 通讯作者, 2021 Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models, 通讯作者, 2021 QKI-5 regulates the alternative splicing of cytoskeletal gene ADD3 in lung cancer, 通讯作者, 2021 LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice, 第13作者, 2020 Auto-regulatory feedback by RNA-binding proteins, 第3作者, 2019 Crystal structure of a Y-box binding protein 1 (YB-1)–RNA complex reveals key features and residues interacting with RNA, 通讯作者, 2019 Opposing roles of mir-294 and mbnl1/2 in shaping the gene regulatory network of embryonic stem cells, 通讯作者, 2018 SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling, 通讯作者, 2017 The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis, 第21作者, 2017 Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis, 第5作者, 2017 QKI5-mediated alternative splicing of the histone variant macroH2A1 regulates gastric carcinogenesis, 第5作者, 2016 Genome-wide analysis of YB-1-RNA interactions reveals a novel role of YB-1 in miRNA processing in glioblastoma multiforme, 通讯作者, 2015 The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing, 第11作者, 2014 YB-1 binds to CAUC motifs and stimulates exon inclusion by enhancing the recruitment of U2AF to weak polypyrimidine tracts, 通讯作者, 2012 HnRNP L-mediated regulation of mammalian alternative splicing by interference with splice site recognition, 第2作者, 2010 The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing, 第3作者, 2010 Auto- and Cross-Regulation of the hnRNP L Proteins by Alternative Splicing ▿ ‡, 第6作者, 2009 Diverse roles of hnRNP L in mammalian mRNA processing: A combined microarray and RNAi analysis, 第3作者, 2008 HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats, Not mentioned, 2003 Novel function role of CA repeats and hnRNP L in RNA stability, 第1作者, 2003 Intronic CA-repeat and CA-rich elements: a new class of regulators of mammalian alternative splicing, 第11作者

Areas of Focus

哺乳动物细胞mRNA剪接的调控与功能

Publications

Upregulated YB-1 protein promotes glioblastoma growth through a YB-1/CCT4/mLST8/mTOR pathway, 通讯作者, 2022
5 ' UTR SNP of FGF13 causes translational defect and intellectual disability, 通讯作者, 2021
Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes, 第4作者, 2021
Msi2-mediated MiR7a-1 processing repression promotes myogenesis, 通讯作者, 2021
Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models, 通讯作者, 2021
QKI-5 regulates the alternative splicing of cytoskeletal gene ADD3 in lung cancer, 通讯作者, 2021
LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice, 第13作者, 2020
Auto-regulatory feedback by RNA-binding proteins, 第3作者, 2019
Crystal structure of a Y-box binding protein 1 (YB-1)–RNA complex reveals key features and residues interacting with RNA, 通讯作者, 2019
Opposing roles of mir-294 and mbnl1/2 in shaping the gene regulatory network of embryonic stem cells, 通讯作者, 2018
SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling, 通讯作者, 2017
The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis, 第21作者, 2017
Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis, 第5作者, 2017
QKI5-mediated alternative splicing of the histone variant macroH2A1 regulates gastric carcinogenesis, 第5作者, 2016
Genome-wide analysis of YB-1-RNA interactions reveals a novel role of YB-1 in miRNA processing in glioblastoma multiforme, 通讯作者, 2015
The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing, 第11作者, 2014
YB-1 binds to CAUC motifs and stimulates exon inclusion by enhancing the recruitment of U2AF to weak polypyrimidine tracts, 通讯作者, 2012
HnRNP L-mediated regulation of mammalian alternative splicing by interference with splice site recognition, 第2作者, 2010
The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing, 第3作者, 2010
Auto- and Cross-Regulation of the hnRNP L Proteins by Alternative Splicing ▿ ‡, 第6作者, 2009
Diverse roles of hnRNP L in mammalian mRNA processing: A combined microarray and RNAi analysis, 第3作者, 2008
HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats, Not mentioned, 2003
Novel function role of CA repeats and hnRNP L in RNA stability, 第1作者, 2003
Intronic CA-repeat and CA-rich elements: a new class of regulators of mammalian alternative splicing, 第11作者

Mrna剪接调控功能哺乳动物细胞基因表达 Rna加工可变剪接分子生物学生物化学细胞生物学

王水 - 上海师范大学

王水 - 上海师范大学

程红 - 中国科学院大学

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