Professor | Yangbo Hu | Asia Growth Partners

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Name	Yangbo Hu
Contact Information	ybhu@wh.iov.cn
Language ability	English, Chinese, French
Province	Hubei

Upload Avatar (500 x 500)

Name

Yangbo Hu

Contact Information

ybhu@wh.iov.cn

Language ability

English, Chinese, French

Province

Hubei

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Work Experience	2018-11 - Present - Wuhan Institute of Virology, Chinese Academy of Sciences - Young Researcher 2012-03 - 2018-10 - Wuhan Institute of Virology, Chinese Academy of Sciences - Associate Researcher 2011-06 - 2012-02 - CNRS CPBS, France - Postdoctoral Researcher
Awards	Hubei Province Excellent Doctoral Dissertation (2012) Chinese Academy of Sciences President's Excellence Award (2011) Chinese Academy of Sciences Excellent Graduate (2011)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Work Experience

2018-11 - Present - Wuhan Institute of Virology, Chinese Academy of Sciences - Young Researcher
2012-03 - 2018-10 - Wuhan Institute of Virology, Chinese Academy of Sciences - Associate Researcher
2011-06 - 2012-02 - CNRS CPBS, France - Postdoctoral Researcher

Awards

Hubei Province Excellent Doctoral Dissertation (2012)
Chinese Academy of Sciences President's Excellence Award (2011)
Chinese Academy of Sciences Excellent Graduate (2011)

Areas of Focus	Yersinia pseudotuberculosis Mycobacterium tuberculosis
Publications	Genome-scale analyses of transcriptional start sites in Mycobacterium marinum under normoxic and hypoxic conditions, Huang, Shaojia, Zhou, Wei, Tang, Wei, Zhang, Yong, Hu, Yangbo, Chen, Shiyun, 2021 Mobile Plasmid Mediated Transition From Colistin-Sensitive to Resistant Phenotype in Klebsiella pneumoniae, Zhang, Baoyue, Yu, Bing, Zhou, Wei, Wang, Yue, Sun, Ziyong, Wu, Xiaojun, Chen, Shiyun, Ni, Ming, Hu, Yangbo, 2021 Inactivating SARS-CoV-2 by electrochemical oxidation, Tu, Yunchuan, Tang, Wei, Yu, Liang, Liu, Zheyi, Liu, Yanting, Xia, Huicong, Zhang, Haiwei, Chen, Shiyun, Wu, Jia, Cui, Xiaoju, Zhang, Jianan, Wang, Fangjun, Hu, Yangbo, Deng, Dehui, 2021 Structural visualization of transcription activated by a multidrug-sensing MerR family regulator, Yang Yang, Chang Liu, Wei Zhou, Wei Shi, Ming Chen, Baoyue Zhang, David G Schatz, Yangbo Hu, Bin Liu, 2021 Structural basis of copper-efflux-regulator-dependent transcription activation, Shi, Wei, Zhang, Baoyue, Jiang, Yanan, Liu, Chang, Zhou, Wei, Chen, Ming, Yang, Yang, Hu, Yangbo, Liu, Bin, 2021 Basal-Level Effects of (p)ppGpp in the Absence of Branched-Chain Amino Acids in Actinobacillus pleuropneumoniae, Li, Gang, Zhao, Qian, Luan, Tian, Hu, Yangbo, Zhang, Yueling, Li, Ting, Wang, Chunlai, Xie, Fang, Zhang, Wanjiang, Langford, Paul R, Liu, Siguo, 2020 Structural basis of bacterial sigma(28)-mediated transcription reveals roles of theRNApolymerase zinc-binding domain, Shi, Wei, Zhou, Wei, Zhang, Baoyue, Huang, Shaojia, Jiang, Yanan, Schammel, Abigail, Hu, Yangbo, Liu, Bin, 2020 Structural basis of bacterial σ 28 ‐mediated transcription reveals roles of the RNA polymerase zinc‐binding domain, Wei Shi, Wei Zhou, Baoyue Zhang, Shaojia Huang, Yanan Jiang, Abigail Schammel, Yangbo Hu, Bin Liu, 2020 Association of omega with the C-Terminal Region of the beta' Subunit Is Essential for Assembly of RNA Polymerase in Mycobacterium tuberculosis, Mao, Chunyou, Zhu, Yan, Lu, Pei, Feng, Lipeng, Chen, Shiyun, Hu, Yangbo, 2018 RbpA relaxes promoter selectivity of M-tuberculosis RNA polymerase, Perumal, Ayyappasamy Sudalaiyadum, Vishwakarma, Rishi Kishore, Hu, Yangbo, Morichaud, Zakia, Brodolin, Konstantin, 2018 RgsA, an RpoS-dependent sRNA, negatively regulates rpoS expression in Pseudomonas aeruginosa, Lu, Pei, Wang, Yifei, Hu, Yangbo, Chen, Shiyun, 2018 PhoPR Positively Regulates whiB3 Expression in Response to Low pH in Pathogenic Mycobacteria, Feng, Lipeng, Chen, Shiyun, Hu, Yangbo, 2018 RbpA and sigma(B) association regulates polyphosphate levels to modulate mycobacterial isoniazid-tolerance, Wang, Zhongwei, Cumming, Bridgette M, Mao, Chunyou, Zhu, Yan, Lu, Pei, Steyn, Adrie J C, Chen, Shiyun, Hu, Yangbo, 2018 A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases, Yixiang Liu, Joshua Rose, Shaojia Huang, Yangbo Hu, Qiong Wu, Dan Wang, Conggang Li, Maili Liu, Pei Zhou, Ling Jiang, 2017 Characterization of a Minimal Type of Promoter Containing the-10 Element and a Guanine at the-14 or-13 Position in Mycobacteria, Zhu, Yan, Mao, Chunyou, Ge, Xingyi, Wang, Zhongwei, Lu, Pei, Zhang, Yong, Chen, Shiyun, Hu, Yangbo, 2017 Deletion of sigB Causes Increased Sensitivity to para-Aminosalicylic Acid and Sulfamethoxazole in Mycobacterium tuberculosis, Yang, ShanShan, Hu, YangBo, Wang, XuDe, Gao, YunRong, Li, Kun, Zhang, XianEn, Chen, ShiYun, Zhang, TianYu, Gu, Ling, Deng, JiaoYu, 2017 Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish, Chen, Zhenkang, Hu, Yangbo, Cumming, Bridgette M, Lu, Pei, Feng, Lipeng, Deng, Jiaoyu, Steyn, Adrie J C, Chen, Shiyun, 2016 Genome-wide characterization of monomeric transcriptional regulators in Mycobacterium tuberculosis, Feng, Lipeng, Chen, Zhenkang, Wang, Zhongwei, Hu, Yangbo, Chen, Shiyun, 2016 σE-dependent activation of RbpA controls transcription of the furA-katG operon in response to oxidative stress in mycobacteria, Chen, Zhenkang, Hu, Yangbo, Cumming, Bridgette M, Lu, Pei, Feng, Lipeng, Deng, Jiaoyu, Steyn, Adrie J C, Chen, Shiyun, 2016 RpoS-dependent sRNA RgsA regulates Fis and AcpP in Pseudomonas aeruginosa, Lu, Pei, Wang, Yifei, Zhang, Yong, Hu, Yangbo, Thompson, Karl M, Chen, Shiyun, 2016 sigma(E)-dependent activation of RbpA controls transcription of the furA-katG operon in response to oxidative stress in mycobacteria, Hu, Yangbo, Wang, Zhongwei, Feng, Lipeng, Chen, Zhenkang, Mao, Chunyou, Zhu, Yan, Chen, Shiyun, 2016 RcsB positively regulates the Yersinia Ysc-Yop type III secretion system by activating expression of the master transcriptional regulator LcrF, Li, Yunlong, Hu, Yangbo, Francis, Matthew S, Chen, Shiyun, 2015 Mycobacterium RbpA cooperates with the stress-response σ B subunit of RNA polymerase in promoter DNA unwinding, Yangbo Hu, Zakia Morichaud, Ayyappasamy SudalaiyadumPerumal, Franoise RoquetBaneres, Konstantin Brodolin, 2014 LcrQ Blocks the Role of LcrF in Regulating the Ysc-Yop Type III Secretion Genes in Yersinia pseudotuberculosis, Li, Lamei, Yan, Huan, Feng, Lipeng, Li, Yunlong, Lu, Pei, Hu, Yangbo, Chen, Shiyun, 2014 A cis-encoded sRNA controls the expression of fabH2 in Yersinia, Lu, Pei, Zhang, Yong, Hu, Yangbo, Francis, Matthew S, Chen, Shiyun, 2014 Yersinia Ysc-Yop type III secretion feedback inhibition is relieved through YscV-dependent recognition and secretion of LcrQ, Li, Yunlong, Li, Lamei, Huang, Li, Francis, Matthew S, Hu, Yangbo, Chen, Shiyun, 2014 Small non-coding RNA SraG regulates the operon YPK_1206-1205 in Yersinia pseudotuberculosis, Lu, Pei, Zhang, Yong, Li, Lamei, Hu, Yangbo, Huang, Li, Li, Yunlong, Rayner, Simon, Chen, Shiyun, 2012 Mycobacterium tuberculosis RbpA protein is a new type of transcriptional activator that stabilizes the Sigma(A)-containing RNA polymerase holoenzyme, Hu, Yangbo, Morichaud, Zakia, Chen, Shiyun, Leonetti, JeanPaul, Brodolin, Konstantin, 2012 Ribosomal Binding Site Switching: An Effective Strategy for High-Throughput Cloning Constructions, Hu, Yangbo, Feng, Lipeng, Li, Yunlong, Zhang, Yong, Lu, Pei, Rayner, Simon, Chen, Shiyun, 2012 Cra negatively regulates acid survival in Yersinia pseudotuberculosis, Hu, Yangbo, Lu, Pei, Zhang, Yong, Li, Yunlong, Li, Lamei, Huang, Li, Chen, Shiyun, 2011 Duckweed (Lemna minor) as a Model Plant System for the Study of Human Microbial Pathogenesis, Zhang, Yong, Hu, Yangbo, Yang, Baoyu, Ma, Fang, Lu, Pei, Li, Lamei, Wan, Chengsong, Rayner, Simon, Chen, Shiyun, 2010 Characterization of an aspartate-dependent acid survival system in Yersinia pseudotuberculosis, Hu, Yangbo, Lu, Pei, Zhang, Yong, Li, Lamei, Chen, Shiyun, 2010 Positive regulation of flhDC expression by OmpR in Yersinia pseudotuberculosis, Hu, Yangbo, Wang, Yao, Ding, Lisha, Lu, Pei, Atkinson, Steve, Chen, Shiyun, 2009 OmpR positively regulates urease expression to enhance acid survival of Yersinia pseudotuberculosis, Hu, Yangbo, Lu, Pei, Wang, Yao, Ding, Lisha, Atkinson, Steve, Chen, Shiyun, 2009 Functional characterization of FlgM in the regulation of flagellar synthesis and motility in Yersinia pseudotuberculosis, Ding, Lisha, Wang, Yao, Hu, Yangbo, Atkinson, Steve, Williams, Paul, Chen, Shiyun, 0200

Areas of Focus

Yersinia pseudotuberculosis
Mycobacterium tuberculosis

Publications

Genome-scale analyses of transcriptional start sites in Mycobacterium marinum under normoxic and hypoxic conditions, Huang, Shaojia, Zhou, Wei, Tang, Wei, Zhang, Yong, Hu, Yangbo, Chen, Shiyun, 2021
Mobile Plasmid Mediated Transition From Colistin-Sensitive to Resistant Phenotype in Klebsiella pneumoniae, Zhang, Baoyue, Yu, Bing, Zhou, Wei, Wang, Yue, Sun, Ziyong, Wu, Xiaojun, Chen, Shiyun, Ni, Ming, Hu, Yangbo, 2021
Inactivating SARS-CoV-2 by electrochemical oxidation, Tu, Yunchuan, Tang, Wei, Yu, Liang, Liu, Zheyi, Liu, Yanting, Xia, Huicong, Zhang, Haiwei, Chen, Shiyun, Wu, Jia, Cui, Xiaoju, Zhang, Jianan, Wang, Fangjun, Hu, Yangbo, Deng, Dehui, 2021
Structural visualization of transcription activated by a multidrug-sensing MerR family regulator, Yang Yang, Chang Liu, Wei Zhou, Wei Shi, Ming Chen, Baoyue Zhang, David G Schatz, Yangbo Hu, Bin Liu, 2021
Structural basis of copper-efflux-regulator-dependent transcription activation, Shi, Wei, Zhang, Baoyue, Jiang, Yanan, Liu, Chang, Zhou, Wei, Chen, Ming, Yang, Yang, Hu, Yangbo, Liu, Bin, 2021
Basal-Level Effects of (p)ppGpp in the Absence of Branched-Chain Amino Acids in Actinobacillus pleuropneumoniae, Li, Gang, Zhao, Qian, Luan, Tian, Hu, Yangbo, Zhang, Yueling, Li, Ting, Wang, Chunlai, Xie, Fang, Zhang, Wanjiang, Langford, Paul R, Liu, Siguo, 2020
Structural basis of bacterial sigma(28)-mediated transcription reveals roles of theRNApolymerase zinc-binding domain, Shi, Wei, Zhou, Wei, Zhang, Baoyue, Huang, Shaojia, Jiang, Yanan, Schammel, Abigail, Hu, Yangbo, Liu, Bin, 2020
Structural basis of bacterial σ 28 ‐mediated transcription reveals roles of the RNA polymerase zinc‐binding domain, Wei Shi, Wei Zhou, Baoyue Zhang, Shaojia Huang, Yanan Jiang, Abigail Schammel, Yangbo Hu, Bin Liu, 2020
Association of omega with the C-Terminal Region of the beta' Subunit Is Essential for Assembly of RNA Polymerase in Mycobacterium tuberculosis, Mao, Chunyou, Zhu, Yan, Lu, Pei, Feng, Lipeng, Chen, Shiyun, Hu, Yangbo, 2018
RbpA relaxes promoter selectivity of M-tuberculosis RNA polymerase, Perumal, Ayyappasamy Sudalaiyadum, Vishwakarma, Rishi Kishore, Hu, Yangbo, Morichaud, Zakia, Brodolin, Konstantin, 2018
RgsA, an RpoS-dependent sRNA, negatively regulates rpoS expression in Pseudomonas aeruginosa, Lu, Pei, Wang, Yifei, Hu, Yangbo, Chen, Shiyun, 2018
PhoPR Positively Regulates whiB3 Expression in Response to Low pH in Pathogenic Mycobacteria, Feng, Lipeng, Chen, Shiyun, Hu, Yangbo, 2018
RbpA and sigma(B) association regulates polyphosphate levels to modulate mycobacterial isoniazid-tolerance, Wang, Zhongwei, Cumming, Bridgette M, Mao, Chunyou, Zhu, Yan, Lu, Pei, Steyn, Adrie J C, Chen, Shiyun, Hu, Yangbo, 2018
A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases, Yixiang Liu, Joshua Rose, Shaojia Huang, Yangbo Hu, Qiong Wu, Dan Wang, Conggang Li, Maili Liu, Pei Zhou, Ling Jiang, 2017
Characterization of a Minimal Type of Promoter Containing the-10 Element and a Guanine at the-14 or-13 Position in Mycobacteria, Zhu, Yan, Mao, Chunyou, Ge, Xingyi, Wang, Zhongwei, Lu, Pei, Zhang, Yong, Chen, Shiyun, Hu, Yangbo, 2017
Deletion of sigB Causes Increased Sensitivity to para-Aminosalicylic Acid and Sulfamethoxazole in Mycobacterium tuberculosis, Yang, ShanShan, Hu, YangBo, Wang, XuDe, Gao, YunRong, Li, Kun, Zhang, XianEn, Chen, ShiYun, Zhang, TianYu, Gu, Ling, Deng, JiaoYu, 2017
Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish, Chen, Zhenkang, Hu, Yangbo, Cumming, Bridgette M, Lu, Pei, Feng, Lipeng, Deng, Jiaoyu, Steyn, Adrie J C, Chen, Shiyun, 2016
Genome-wide characterization of monomeric transcriptional regulators in Mycobacterium tuberculosis, Feng, Lipeng, Chen, Zhenkang, Wang, Zhongwei, Hu, Yangbo, Chen, Shiyun, 2016
σE-dependent activation of RbpA controls transcription of the furA-katG operon in response to oxidative stress in mycobacteria, Chen, Zhenkang, Hu, Yangbo, Cumming, Bridgette M, Lu, Pei, Feng, Lipeng, Deng, Jiaoyu, Steyn, Adrie J C, Chen, Shiyun, 2016
RpoS-dependent sRNA RgsA regulates Fis and AcpP in Pseudomonas aeruginosa, Lu, Pei, Wang, Yifei, Zhang, Yong, Hu, Yangbo, Thompson, Karl M, Chen, Shiyun, 2016
sigma(E)-dependent activation of RbpA controls transcription of the furA-katG operon in response to oxidative stress in mycobacteria, Hu, Yangbo, Wang, Zhongwei, Feng, Lipeng, Chen, Zhenkang, Mao, Chunyou, Zhu, Yan, Chen, Shiyun, 2016
RcsB positively regulates the Yersinia Ysc-Yop type III secretion system by activating expression of the master transcriptional regulator LcrF, Li, Yunlong, Hu, Yangbo, Francis, Matthew S, Chen, Shiyun, 2015
Mycobacterium RbpA cooperates with the stress-response σ B subunit of RNA polymerase in promoter DNA unwinding, Yangbo Hu, Zakia Morichaud, Ayyappasamy SudalaiyadumPerumal, Franoise RoquetBaneres, Konstantin Brodolin, 2014
LcrQ Blocks the Role of LcrF in Regulating the Ysc-Yop Type III Secretion Genes in Yersinia pseudotuberculosis, Li, Lamei, Yan, Huan, Feng, Lipeng, Li, Yunlong, Lu, Pei, Hu, Yangbo, Chen, Shiyun, 2014
A cis-encoded sRNA controls the expression of fabH2 in Yersinia, Lu, Pei, Zhang, Yong, Hu, Yangbo, Francis, Matthew S, Chen, Shiyun, 2014
Yersinia Ysc-Yop type III secretion feedback inhibition is relieved through YscV-dependent recognition and secretion of LcrQ, Li, Yunlong, Li, Lamei, Huang, Li, Francis, Matthew S, Hu, Yangbo, Chen, Shiyun, 2014
Small non-coding RNA SraG regulates the operon YPK_1206-1205 in Yersinia pseudotuberculosis, Lu, Pei, Zhang, Yong, Li, Lamei, Hu, Yangbo, Huang, Li, Li, Yunlong, Rayner, Simon, Chen, Shiyun, 2012
Mycobacterium tuberculosis RbpA protein is a new type of transcriptional activator that stabilizes the Sigma(A)-containing RNA polymerase holoenzyme, Hu, Yangbo, Morichaud, Zakia, Chen, Shiyun, Leonetti, JeanPaul, Brodolin, Konstantin, 2012
Ribosomal Binding Site Switching: An Effective Strategy for High-Throughput Cloning Constructions, Hu, Yangbo, Feng, Lipeng, Li, Yunlong, Zhang, Yong, Lu, Pei, Rayner, Simon, Chen, Shiyun, 2012
Cra negatively regulates acid survival in Yersinia pseudotuberculosis, Hu, Yangbo, Lu, Pei, Zhang, Yong, Li, Yunlong, Li, Lamei, Huang, Li, Chen, Shiyun, 2011
Duckweed (Lemna minor) as a Model Plant System for the Study of Human Microbial Pathogenesis, Zhang, Yong, Hu, Yangbo, Yang, Baoyu, Ma, Fang, Lu, Pei, Li, Lamei, Wan, Chengsong, Rayner, Simon, Chen, Shiyun, 2010
Characterization of an aspartate-dependent acid survival system in Yersinia pseudotuberculosis, Hu, Yangbo, Lu, Pei, Zhang, Yong, Li, Lamei, Chen, Shiyun, 2010
Positive regulation of flhDC expression by OmpR in Yersinia pseudotuberculosis, Hu, Yangbo, Wang, Yao, Ding, Lisha, Lu, Pei, Atkinson, Steve, Chen, Shiyun, 2009
OmpR positively regulates urease expression to enhance acid survival of Yersinia pseudotuberculosis, Hu, Yangbo, Lu, Pei, Wang, Yao, Ding, Lisha, Atkinson, Steve, Chen, Shiyun, 2009
Functional characterization of FlgM in the regulation of flagellar synthesis and motility in Yersinia pseudotuberculosis, Ding, Lisha, Wang, Yao, Hu, Yangbo, Atkinson, Steve, Williams, Paul, Chen, Shiyun, 0200

Pathogenic Bacteria Gene Expression Function Regulation Virulence Infection Latency Drug Resistance Stress Tolerance Drug Targets Mechanisms

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