Areas of Focus
- Pathogenesis and drug resistance mechanisms in acute leukemia
- Development of targeted immunotherapies for leukemia
Work Experience
- 2023.2 to present - Tongji University Affiliated Eastern Hospital, Translational Medicine Center; Researcher
- 2022.9 to present - Tongji University School of Life Sciences and Technology / Tongji University Advanced Research Institute; Distinguished Researcher
- 2016.3-2020 - City of Hope National Medical Center, USA; Postdoctoral Fellow/In-Service Scientist
Academic Background & Achievements
- 2010.9-2016.1 PhD: Chinese Academy of Sciences, Beijing Institute of Genomics
- Selected for Shanghai Overseas High-Level Talent Plan
Publications
- Phosphoproteomic Characterization and Kinase Signature Predict Response to Venetoclax plus 3+7 Chemotherapy in AML, Jin J, Hou SY, Yao YY, Mao LP, Yang M, Tong HY, Zeng T, Huang JY, Zhu YH, Wang HF, 2023
- Identification of a novel NPM1 mutation in acute myeloid leukemia, Yao YY, Lin XJ, Wang C, Gu Y, Jin J, Zhu YH, Wang HF, 2023
- CD38-directed, single-chain T cell-engager targets leukemia stem cells through IFNγ-induced CD38 expression, Murtadha M, Park M, Zhu YH, Caserta E, Napolitano O, Tandoh T, Moloudizargari M, Pozhitkov A, Singer M, Dona AA, Vahed H, Gonzalez A, Ly K, Ouyang C, Sanchez JF, Nigam L, Chowdhury A, Ghoda L, Li L, Zhang B, Krishnan A, Marcucci G, Williams JC, Pichiorri F, 2024
- Phosphoproteomics profiling reveals a kinase network conferring acute myeloid leukaemia intrinsic chemoresistance and indicates HMGA1 phosphorylation as a potential influencer, Zhu YH, He X, Li S, Gan YC, Li Z, Wang HY, et al., and Li L, 2022
- Targeting PRMT1-Mediated FLT3 Methylation Disrupts Maintenance of MLL- rearranged Acute Lymphoblastic Leukemia, Zhu YH, He X, Lin YC, Dong HJ, Zhang L, Chen XC, Wang ZH, Shen YD, Li M, Wang HY, Sun J, Nguyen LX, Zhang H, Jiang WJ, Yang YZ, Chen JJ, Müschen M, Chen CW, Konopleva MY, Sun WL, Jin J, Carlesso N, Marcucci G, Luo Y, and Li L, 2019
- A Comprehensive Proteomics Analysis Reveals a Secretory Path- and Status-Dependent Signature of Exosomes Released from Tumor-Associated Macrophages, Zhu YH, Chen XW, Pan QF, Wang Y, Su SY, Jiang CC, Li Y, Xu NZ, Wu L, Lou XM, and Liu SQ, 2015
- mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances, Chen XW, Zhu YH, Wang ZH, Zhu HS, Pan QF, Su SY, et al., Liu SQ, 2016
- SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function, Sun J, He X, Zhu YH, Ding ZH, Dong HJ, Feng YM, Du J, Wang HY, Wu XW, Zhang L, Yu XC, Lin A, McDonald T, Zhao DD, Wu H, Hua WK, Zhang B, Feng LF, Tohyama K, Bhatia R, Oberdoerffer P, Chung YJ, Peter DA, Jacqueline B, Andrea P, Samer K, Marcin K, Pichiorri F, Kuo YH, Carlesso N, Guido M, Jin HC, and Li L, 2018
