Professor | Yinghui Zhu | Asia Growth Partners

Name	Yinghui Zhu
Contact Information	zhuyinghui@tongji.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Yinghui Zhu

Contact Information

zhuyinghui@tongji.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Tongji University
Faculty	Life Sciences
Academic Background & Achievements	2010.9-2016.1 PhD: Chinese Academy of Sciences, Beijing Institute of Genomics Selected for Shanghai Overseas High-Level Talent Plan
Work Experience	2023.2 to present - Tongji University Affiliated Eastern Hospital, Translational Medicine Center; Researcher 2022.9 to present - Tongji University School of Life Sciences and Technology / Tongji University Advanced Research Institute; Distinguished Researcher 2016.3-2020 - City of Hope National Medical Center, USA; Postdoctoral Fellow/In-Service Scientist

University/Lab Affiliation and Title

Tongji University

Faculty

Life Sciences

Academic Background & Achievements

2010.9-2016.1 PhD: Chinese Academy of Sciences, Beijing Institute of Genomics
Selected for Shanghai Overseas High-Level Talent Plan

Work Experience

2023.2 to present - Tongji University Affiliated Eastern Hospital, Translational Medicine Center; Researcher
2022.9 to present - Tongji University School of Life Sciences and Technology / Tongji University Advanced Research Institute; Distinguished Researcher
2016.3-2020 - City of Hope National Medical Center, USA; Postdoctoral Fellow/In-Service Scientist

Areas of Focus	Pathogenesis and drug resistance mechanisms in acute leukemia Development of targeted immunotherapies for leukemia
Publications	Phosphoproteomic Characterization and Kinase Signature Predict Response to Venetoclax plus 3+7 Chemotherapy in AML, Jin J, Hou SY, Yao YY, Mao LP, Yang M, Tong HY, Zeng T, Huang JY, Zhu YH, Wang HF, 2023 Identification of a novel NPM1 mutation in acute myeloid leukemia, Yao YY, Lin XJ, Wang C, Gu Y, Jin J, Zhu YH, Wang HF, 2023 CD38-directed, single-chain T cell-engager targets leukemia stem cells through IFNγ-induced CD38 expression, Murtadha M, Park M, Zhu YH, Caserta E, Napolitano O, Tandoh T, Moloudizargari M, Pozhitkov A, Singer M, Dona AA, Vahed H, Gonzalez A, Ly K, Ouyang C, Sanchez JF, Nigam L, Chowdhury A, Ghoda L, Li L, Zhang B, Krishnan A, Marcucci G, Williams JC, Pichiorri F, 2024 Phosphoproteomics profiling reveals a kinase network conferring acute myeloid leukaemia intrinsic chemoresistance and indicates HMGA1 phosphorylation as a potential influencer, Zhu YH, He X, Li S, Gan YC, Li Z, Wang HY, et al., and Li L, 2022 Targeting PRMT1-Mediated FLT3 Methylation Disrupts Maintenance of MLL- rearranged Acute Lymphoblastic Leukemia, Zhu YH, He X, Lin YC, Dong HJ, Zhang L, Chen XC, Wang ZH, Shen YD, Li M, Wang HY, Sun J, Nguyen LX, Zhang H, Jiang WJ, Yang YZ, Chen JJ, Müschen M, Chen CW, Konopleva MY, Sun WL, Jin J, Carlesso N, Marcucci G, Luo Y, and Li L, 2019 A Comprehensive Proteomics Analysis Reveals a Secretory Path- and Status-Dependent Signature of Exosomes Released from Tumor-Associated Macrophages, Zhu YH, Chen XW, Pan QF, Wang Y, Su SY, Jiang CC, Li Y, Xu NZ, Wu L, Lou XM, and Liu SQ, 2015 mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances, Chen XW, Zhu YH, Wang ZH, Zhu HS, Pan QF, Su SY, et al., Liu SQ, 2016 SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function, Sun J, He X, Zhu YH, Ding ZH, Dong HJ, Feng YM, Du J, Wang HY, Wu XW, Zhang L, Yu XC, Lin A, McDonald T, Zhao DD, Wu H, Hua WK, Zhang B, Feng LF, Tohyama K, Bhatia R, Oberdoerffer P, Chung YJ, Peter DA, Jacqueline B, Andrea P, Samer K, Marcin K, Pichiorri F, Kuo YH, Carlesso N, Guido M, Jin HC, and Li L, 2018

Areas of Focus

Pathogenesis and drug resistance mechanisms in acute leukemia
Development of targeted immunotherapies for leukemia

Publications

Phosphoproteomic Characterization and Kinase Signature Predict Response to Venetoclax plus 3+7 Chemotherapy in AML, Jin J, Hou SY, Yao YY, Mao LP, Yang M, Tong HY, Zeng T, Huang JY, Zhu YH, Wang HF, 2023
Identification of a novel NPM1 mutation in acute myeloid leukemia, Yao YY, Lin XJ, Wang C, Gu Y, Jin J, Zhu YH, Wang HF, 2023
CD38-directed, single-chain T cell-engager targets leukemia stem cells through IFNγ-induced CD38 expression, Murtadha M, Park M, Zhu YH, Caserta E, Napolitano O, Tandoh T, Moloudizargari M, Pozhitkov A, Singer M, Dona AA, Vahed H, Gonzalez A, Ly K, Ouyang C, Sanchez JF, Nigam L, Chowdhury A, Ghoda L, Li L, Zhang B, Krishnan A, Marcucci G, Williams JC, Pichiorri F, 2024
Phosphoproteomics profiling reveals a kinase network conferring acute myeloid leukaemia intrinsic chemoresistance and indicates HMGA1 phosphorylation as a potential influencer, Zhu YH, He X, Li S, Gan YC, Li Z, Wang HY, et al., and Li L, 2022
Targeting PRMT1-Mediated FLT3 Methylation Disrupts Maintenance of MLL- rearranged Acute Lymphoblastic Leukemia, Zhu YH, He X, Lin YC, Dong HJ, Zhang L, Chen XC, Wang ZH, Shen YD, Li M, Wang HY, Sun J, Nguyen LX, Zhang H, Jiang WJ, Yang YZ, Chen JJ, Müschen M, Chen CW, Konopleva MY, Sun WL, Jin J, Carlesso N, Marcucci G, Luo Y, and Li L, 2019
A Comprehensive Proteomics Analysis Reveals a Secretory Path- and Status-Dependent Signature of Exosomes Released from Tumor-Associated Macrophages, Zhu YH, Chen XW, Pan QF, Wang Y, Su SY, Jiang CC, Li Y, Xu NZ, Wu L, Lou XM, and Liu SQ, 2015
mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances, Chen XW, Zhu YH, Wang ZH, Zhu HS, Pan QF, Su SY, et al., Liu SQ, 2016
SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function, Sun J, He X, Zhu YH, Ding ZH, Dong HJ, Feng YM, Du J, Wang HY, Wu XW, Zhang L, Yu XC, Lin A, McDonald T, Zhao DD, Wu H, Hua WK, Zhang B, Feng LF, Tohyama K, Bhatia R, Oberdoerffer P, Chung YJ, Peter DA, Jacqueline B, Andrea P, Samer K, Marcin K, Pichiorri F, Kuo YH, Carlesso N, Guido M, Jin HC, and Li L, 2018

Leukemia Acute Pathogenesis Drug Resistance Mechanisms Targeted Immunotherapy Development Clinical Application Multidimensional Omics

Mingqian Feng - Huazhong Agricultural University

Yinghui Zhu - Tongji University

Lei Sun - Fudan University

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