Professor | Yihua Huang | Asia Growth Partners

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Name	Yihua Huang
Contact Information	yihuahuang@sun5.ibp.ac.cn
Language ability	English, Chinese
Province	Beijing

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Name

Yihua Huang

Contact Information

yihuahuang@sun5.ibp.ac.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1998-07 to 2004-02 Ph.D.: Cornell University 1995-09 to 1998-07 Master's Degree: Peking University 1990-09 to 1995-07 Bachelor's Degree: Peking University
Work Experience	2010-09 to Present - Institute of Biophysics, Chinese Academy of Sciences - Research Group Leader 2004-03 to 2010-08 - UT Southwestern Medical Center/HHMI - Postdoctoral Fellow/Assistant Researcher/Lecturer

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1998-07 to 2004-02 Ph.D.: Cornell University
1995-09 to 1998-07 Master's Degree: Peking University
1990-09 to 1995-07 Bachelor's Degree: Peking University

Work Experience

2010-09 to Present - Institute of Biophysics, Chinese Academy of Sciences - Research Group Leader
2004-03 to 2010-08 - UT Southwestern Medical Center/HHMI - Postdoctoral Fellow/Assistant Researcher/Lecturer

Areas of Focus	Membrane Protein Structural Biology
Publications	Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins, Han L, Zheng J, Wang Y, Yang X, Liu Y, Sun C, Cao B, Zhou H, Ni D, Lou J, Zhao Y, Huang Y, 2016 The Expression, Purification, and Structure Determination of BamA from E. coli, Ni D, Huang Y, 2015 Structure of the nonameric bacterial amyloid secretion channel, Cao B, Zhao Y, Kou Y, Ni D, Zhang XC, Huang Y, 2014 Structural basis for lipopolysaccharide insertion in the bacterial outer membrane, Qiao S, Luo Q, Zhao Y, Zhang XC, Huang Y, 2014 Refolding, crystallization and preliminary X-ray crystallographic studies of the β-barrel domain of BamA, a membrane protein essential for outer membrane protein biogenesis, Ni D, Yang K, Huang Y, 2014 Structural and functional analysis of the β-barrel domain of BamA from Escherichia coli, Ni D, Wang Y, Yang X, Zhou H, Hou X, Cao B, Lu Z, Zhao X, Yang K, Huang Y, 2014 Insights into pilus assembly and secretion from the structure and functional characterization of usher PapC, Huang Y, Smith B, Chen L, Baxter R, Deisenhofer J, 2009 Crystal structure of cryptochrome 3 from Arabidopsis thaliana and its implication for photolyase activity, Huang Y, Baxter R, Smith BS, Partch CL, Colbert CL, Deisenhofer J, 2006 Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain, Huang Y, Park YC, Rich RL, Segal D, Myszka DG, Wu H, 2001 Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac, Huang Y, Rich R, Myszkat D, Wu H, 2003 Antagonizing XIAP-mediated caspase-3 inhibition: Achilles' heel of cancers?, Huang Y, Lu M, Wu H, 2004 Covalent inhibition revealed by the crystal structure of the p35/caspase-8 complex, Xu G, Cirilli M, Huang Y, Rich RL, Myszka DG, Wu H, 2001 Crystal structure of the BIR1 domain of XIAP In two crystal forms, Lin SC, Huang Y, Lo YC, Lu M, Wu H, 2007 XIAP induces NF-κB activation via the BIR1/TAB1 interaction and BIR1 dimerization, Lu M, Lin S, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H, 2007 Mutational analysis of the p35-caspase interaction: A bowstring kinetic model of caspase inhibition by p35, Xu G, Rich RL, Steegborn C, Min T, Huang Y, Myszka DG, Wu H, 2003 Calcium dependence of myocardial hypothermial tolerance on sources of activator, Wang S, Huang Y, Zhou Z, 1997

Areas of Focus

Membrane Protein Structural Biology

Publications

Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins, Han L, Zheng J, Wang Y, Yang X, Liu Y, Sun C, Cao B, Zhou H, Ni D, Lou J, Zhao Y, Huang Y, 2016
The Expression, Purification, and Structure Determination of BamA from E. coli, Ni D, Huang Y, 2015
Structure of the nonameric bacterial amyloid secretion channel, Cao B, Zhao Y, Kou Y, Ni D, Zhang XC, Huang Y, 2014
Structural basis for lipopolysaccharide insertion in the bacterial outer membrane, Qiao S, Luo Q, Zhao Y, Zhang XC, Huang Y, 2014
Refolding, crystallization and preliminary X-ray crystallographic studies of the β-barrel domain of BamA, a membrane protein essential for outer membrane protein biogenesis, Ni D, Yang K, Huang Y, 2014
Structural and functional analysis of the β-barrel domain of BamA from Escherichia coli, Ni D, Wang Y, Yang X, Zhou H, Hou X, Cao B, Lu Z, Zhao X, Yang K, Huang Y, 2014
Insights into pilus assembly and secretion from the structure and functional characterization of usher PapC, Huang Y, Smith B, Chen L, Baxter R, Deisenhofer J, 2009
Crystal structure of cryptochrome 3 from Arabidopsis thaliana and its implication for photolyase activity, Huang Y, Baxter R, Smith BS, Partch CL, Colbert CL, Deisenhofer J, 2006
Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain, Huang Y, Park YC, Rich RL, Segal D, Myszka DG, Wu H, 2001
Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac, Huang Y, Rich R, Myszkat D, Wu H, 2003
Antagonizing XIAP-mediated caspase-3 inhibition: Achilles' heel of cancers?, Huang Y, Lu M, Wu H, 2004
Covalent inhibition revealed by the crystal structure of the p35/caspase-8 complex, Xu G, Cirilli M, Huang Y, Rich RL, Myszka DG, Wu H, 2001
Crystal structure of the BIR1 domain of XIAP In two crystal forms, Lin SC, Huang Y, Lo YC, Lu M, Wu H, 2007
XIAP induces NF-κB activation via the BIR1/TAB1 interaction and BIR1 dimerization, Lu M, Lin S, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H, 2007
Mutational analysis of the p35-caspase interaction: A bowstring kinetic model of caspase inhibition by p35, Xu G, Rich RL, Steegborn C, Min T, Huang Y, Myszka DG, Wu H, 2003
Calcium dependence of myocardial hypothermial tolerance on sources of activator, Wang S, Huang Y, Zhou Z, 1997

Membrane Protein Structure Biology X-Ray Crystallography Biogenesis Function Mechanism Polysaccharide

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