Professor | Zhenghui Huang | Asia Growth Partners

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Name	Zhenghui Huang
Contact Information	zhhuang@ips.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Zhenghui Huang

Contact Information

zhhuang@ips.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2014-09 to 2020-07 PhD in Science: Shanghai Institute of Pasteur, Chinese Academy of Sciences 2010-09 to 2014-07 Bachelor's in Science: Sichuan University
Work Experience	2022-10 to 2023-06 - Shanghai Institute of Pasteur, Chinese Academy of Sciences - Associate Researcher 2020-07 to 2022-09 - Shanghai Institute of Pasteur, Chinese Academy of Sciences - Postdoctoral Researcher 2014-09 to 2020-07 - Shanghai Institute of Pasteur, Chinese Academy of Sciences - PhD in Science 2010-09 to 2014-07 - Sichuan University - Bachelor's in Science
Awards	Second Prize (2021): Integration and Promotion of Key Technologies for the Elimination of Malaria and Schistosomiasis, Provincial Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2014-09 to 2020-07 PhD in Science: Shanghai Institute of Pasteur, Chinese Academy of Sciences
2010-09 to 2014-07 Bachelor's in Science: Sichuan University

Work Experience

2022-10 to 2023-06 - Shanghai Institute of Pasteur, Chinese Academy of Sciences - Associate Researcher
2020-07 to 2022-09 - Shanghai Institute of Pasteur, Chinese Academy of Sciences - Postdoctoral Researcher
2014-09 to 2020-07 - Shanghai Institute of Pasteur, Chinese Academy of Sciences - PhD in Science
2010-09 to 2014-07 - Sichuan University - Bachelor's in Science

Awards

Second Prize (2021): Integration and Promotion of Key Technologies for the Elimination of Malaria and Schistosomiasis, Provincial Level

Areas of Focus	Pathogen-Host Interaction and Epigenetics Vaccine Development High-Throughput Drug Screening
Publications	Discovery of Novel Plasmodium falciparum HDAC1 Inhibitors with Dual-Stage Antimalarial Potency and Improved Safety Based on the Clinical Anticancer Drug Candidate Quisinostat, 4th Author, 2021 Repurposing of antitumor drug candidate Quisinostat lead to novel spirocyclic antimalarial agents, 4th Author, 2021 Discovery of 6′-chloro-N-methyl-5′-(phenylsulfonamido)-3,3′-bipyridine-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium, 3rd Author, 2020 A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1, 1st Author, 2020 Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an anaplastic lymphoma kinase inhibitor, 2nd Author, 2020 The immunologic dominance of an epitope within a rationally designed poly-epitope vaccine is influenced by multiple factors, 7th Author, 2020 DNA helicase RecQ1 regulates mutually exclusive expression of virulence genes in Plasmodium falciparum via heterochromatin alteration, 11th Author, 2019 Novel dual inhibitors against FP-2 and PfDHFR as potential antimalarial agents: Design, synthesis and biological evaluation, 3rd Author, 2019 Epigenetic editing by CRISPR/dCas9 in Plasmodium falciparum, 6th Author, 2019 Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembly, 2nd Author, 2017

Areas of Focus

Pathogen-Host Interaction and Epigenetics
Vaccine Development
High-Throughput Drug Screening

Publications

Discovery of Novel Plasmodium falciparum HDAC1 Inhibitors with Dual-Stage Antimalarial Potency and Improved Safety Based on the Clinical Anticancer Drug Candidate Quisinostat, 4th Author, 2021
Repurposing of antitumor drug candidate Quisinostat lead to novel spirocyclic antimalarial agents, 4th Author, 2021
Discovery of 6′-chloro-N-methyl-5′-(phenylsulfonamido)-3,3′-bipyridine-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium, 3rd Author, 2020
A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1, 1st Author, 2020
Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an anaplastic lymphoma kinase inhibitor, 2nd Author, 2020
The immunologic dominance of an epitope within a rationally designed poly-epitope vaccine is influenced by multiple factors, 7th Author, 2020
DNA helicase RecQ1 regulates mutually exclusive expression of virulence genes in Plasmodium falciparum via heterochromatin alteration, 11th Author, 2019
Novel dual inhibitors against FP-2 and PfDHFR as potential antimalarial agents: Design, synthesis and biological evaluation, 3rd Author, 2019
Epigenetic editing by CRISPR/dCas9 in Plasmodium falciparum, 6th Author, 2019
Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembly, 2nd Author, 2017

Pathogen Host Interaction Epigenetics Vaccine Development High-Throughput Drug Screening Research

Shi Jiejun - Tongji University

Yixuan Wang - Tongji University

Peng Yang - Tongji University

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