Upload Avatar (500 x 500)
Xiaolong Liu
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Immunology: Immune Cells
Differentiation
Function
Immune Response
T Cells
B Cells
Nk Cells
Cytokines
Immunotherapy
Inflammation
Cell Biology: Cell Structure
Cell Function
Cell Signaling
Cell Differentiation
Cell Cycle
Apoptosis
Stem Cells
Cellular Metabolism
Organelles
Cell Communication
Areas of Focus
- Immunology
- Cell Biology
Work Experience
- 2004-10 to Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Research Group Leader
- 1999-10 to 2004-09 - NCI/NIH - Postdoctoral Researcher
- 1994-09 to 1999-07 - Shanghai Institute of Biochemistry, Chinese Academy of Sciences - Secretary of the Youth League Committee/PhD
- 1990-09 to 1994-07 - Nanchang University - Deputy Secretary of the Youth League Committee/Bachelor
Academic Background & Achievements
- 1994-09 to 1999-07 PhD: Shanghai Institute of Biochemistry, Chinese Academy of Sciences
- 1990-09 to 1994-07 Bachelor: Nanchang University
Publications
- Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis, NATURE COMMUNICATIONS, 2022
- Chromatin assembly factor 1B critically controls the early development but not function acquisition of invariant natural killer T cells in mice, EUROPEAN JOURNAL OF IMMUNOLOGY, 2021
- The evolution of zebrafish RAG2 protein is required for adapting to the elevated body temperature of the higher endothermic vertebrates, SCIENTIFIC REPORTS, 2020
- Unveiling the heterogeneity of NKT cells in the liver through single cell RNA sequencing, SCIENTIFIC REPORTS, 2020
- Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction, EUROPEAN JOURNAL OF IMMUNOLOGY, 2019
- TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity, THE JOURNAL OF EXPERIMENTAL MEDICINE, 2019
- Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells, NATURE COMMUNICATIONS, 2018
- Th-POK regulates mammary gland lactation through mTOR-SREBP pathway, PLOS GENETICS, 2018
- FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells, NATURE, 2018
- Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23, NATURE COMMUNICATIONS, 2018
- PD-1 Controls Follicular T Helper Cell Positioning and Function, IMMUNITY, 2018
- Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking, SCIENTIFIC REPORTS, 2017
- Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017
- Lis1 Regulates Germinal Center B Cell Antigen Acquisition and Affinity Maturation, JOURNAL OF IMMUNOLOGY, 2017
- Dynamic regulation of CD28 conformation and signaling by charged lipids and ions, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2017
- Reconstituted Thymus Organ Culture., Methods Mol Biol., 2016
- Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency, EUROPEAN JOURNAL OF IMMUNOLOGY, 2016
- Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis, CELL REPORTS, 2016
- RAG1-mediated ubiquitylation of histone H3 is required for chromosomal V(D)J recombination, CELL RESEARCH, 2015
- The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity, NATURE COMMUNICATIONS, 2014
- An amphioxus RAG1-like DNA fragment encodes a functional central domain of vertebrate core RAG1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014
- Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012
- LKB1 regulates TCR-mediated PLC gamma 1 activation and thymocyte positive selection, EMBO JOURNAL, 2011
- p300-Mediated Acetylation Stabilizes the Th-Inducing POK Factor, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, 2010
- Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition, NATURE IMMUNOLOGY, 2008
Awards
- National Special Support Program for High-Level Talents (2016): National Level
- A-IMBN Research Young Investigators Award (2012): Other
- National Excellent Doctoral Dissertation Supervisor (2011): National Level
- 11th China Youth Science and Technology Award (2010): First Prize, National Level
- Excellent Graduate Student Supervisor of the Chinese Academy of Sciences (2010): First Prize, Institute Level
- Excellent Final Assessment of the Chinese Academy of Sciences (2008): First Prize, Institute Level
