Professor | Xiaolong Liu | Asia Growth Partners

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Name	Xiaolong Liu
Contact Information	liux@sibcb.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Xiaolong Liu

Contact Information

liux@sibcb.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1994-09 to 1999-07 PhD: Shanghai Institute of Biochemistry, Chinese Academy of Sciences 1990-09 to 1994-07 Bachelor: Nanchang University
Work Experience	2004-10 to Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Research Group Leader 1999-10 to 2004-09 - NCI/NIH - Postdoctoral Researcher 1994-09 to 1999-07 - Shanghai Institute of Biochemistry, Chinese Academy of Sciences - Secretary of the Youth League Committee/PhD 1990-09 to 1994-07 - Nanchang University - Deputy Secretary of the Youth League Committee/Bachelor
Awards	National Special Support Program for High-Level Talents (2016): National Level A-IMBN Research Young Investigators Award (2012): Other National Excellent Doctoral Dissertation Supervisor (2011): National Level 11th China Youth Science and Technology Award (2010): First Prize, National Level Excellent Graduate Student Supervisor of the Chinese Academy of Sciences (2010): First Prize, Institute Level Excellent Final Assessment of the Chinese Academy of Sciences (2008): First Prize, Institute Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1994-09 to 1999-07 PhD: Shanghai Institute of Biochemistry, Chinese Academy of Sciences
1990-09 to 1994-07 Bachelor: Nanchang University

Work Experience

2004-10 to Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Research Group Leader
1999-10 to 2004-09 - NCI/NIH - Postdoctoral Researcher
1994-09 to 1999-07 - Shanghai Institute of Biochemistry, Chinese Academy of Sciences - Secretary of the Youth League Committee/PhD
1990-09 to 1994-07 - Nanchang University - Deputy Secretary of the Youth League Committee/Bachelor

Awards

National Special Support Program for High-Level Talents (2016): National Level
A-IMBN Research Young Investigators Award (2012): Other
National Excellent Doctoral Dissertation Supervisor (2011): National Level
11th China Youth Science and Technology Award (2010): First Prize, National Level
Excellent Graduate Student Supervisor of the Chinese Academy of Sciences (2010): First Prize, Institute Level
Excellent Final Assessment of the Chinese Academy of Sciences (2008): First Prize, Institute Level

Areas of Focus	Immunology Cell Biology
Publications	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis, NATURE COMMUNICATIONS, 2022 Chromatin assembly factor 1B critically controls the early development but not function acquisition of invariant natural killer T cells in mice, EUROPEAN JOURNAL OF IMMUNOLOGY, 2021 The evolution of zebrafish RAG2 protein is required for adapting to the elevated body temperature of the higher endothermic vertebrates, SCIENTIFIC REPORTS, 2020 Unveiling the heterogeneity of NKT cells in the liver through single cell RNA sequencing, SCIENTIFIC REPORTS, 2020 Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction, EUROPEAN JOURNAL OF IMMUNOLOGY, 2019 TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity, THE JOURNAL OF EXPERIMENTAL MEDICINE, 2019 Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells, NATURE COMMUNICATIONS, 2018 Th-POK regulates mammary gland lactation through mTOR-SREBP pathway, PLOS GENETICS, 2018 FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells, NATURE, 2018 Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23, NATURE COMMUNICATIONS, 2018 PD-1 Controls Follicular T Helper Cell Positioning and Function, IMMUNITY, 2018 Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking, SCIENTIFIC REPORTS, 2017 Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017 Lis1 Regulates Germinal Center B Cell Antigen Acquisition and Affinity Maturation, JOURNAL OF IMMUNOLOGY, 2017 Dynamic regulation of CD28 conformation and signaling by charged lipids and ions, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2017 Reconstituted Thymus Organ Culture., Methods Mol Biol., 2016 Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency, EUROPEAN JOURNAL OF IMMUNOLOGY, 2016 Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis, CELL REPORTS, 2016 RAG1-mediated ubiquitylation of histone H3 is required for chromosomal V(D)J recombination, CELL RESEARCH, 2015 The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity, NATURE COMMUNICATIONS, 2014 An amphioxus RAG1-like DNA fragment encodes a functional central domain of vertebrate core RAG1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014 Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012 LKB1 regulates TCR-mediated PLC gamma 1 activation and thymocyte positive selection, EMBO JOURNAL, 2011 p300-Mediated Acetylation Stabilizes the Th-Inducing POK Factor, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, 2010 Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition, NATURE IMMUNOLOGY, 2008

Areas of Focus

Immunology
Cell Biology

Publications

Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis, NATURE COMMUNICATIONS, 2022
Chromatin assembly factor 1B critically controls the early development but not function acquisition of invariant natural killer T cells in mice, EUROPEAN JOURNAL OF IMMUNOLOGY, 2021
The evolution of zebrafish RAG2 protein is required for adapting to the elevated body temperature of the higher endothermic vertebrates, SCIENTIFIC REPORTS, 2020
Unveiling the heterogeneity of NKT cells in the liver through single cell RNA sequencing, SCIENTIFIC REPORTS, 2020
Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction, EUROPEAN JOURNAL OF IMMUNOLOGY, 2019
TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity, THE JOURNAL OF EXPERIMENTAL MEDICINE, 2019
Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells, NATURE COMMUNICATIONS, 2018
Th-POK regulates mammary gland lactation through mTOR-SREBP pathway, PLOS GENETICS, 2018
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells, NATURE, 2018
Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23, NATURE COMMUNICATIONS, 2018
PD-1 Controls Follicular T Helper Cell Positioning and Function, IMMUNITY, 2018
Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking, SCIENTIFIC REPORTS, 2017
Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017
Lis1 Regulates Germinal Center B Cell Antigen Acquisition and Affinity Maturation, JOURNAL OF IMMUNOLOGY, 2017
Dynamic regulation of CD28 conformation and signaling by charged lipids and ions, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2017
Reconstituted Thymus Organ Culture., Methods Mol Biol., 2016
Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency, EUROPEAN JOURNAL OF IMMUNOLOGY, 2016
Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis, CELL REPORTS, 2016
RAG1-mediated ubiquitylation of histone H3 is required for chromosomal V(D)J recombination, CELL RESEARCH, 2015
The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity, NATURE COMMUNICATIONS, 2014
An amphioxus RAG1-like DNA fragment encodes a functional central domain of vertebrate core RAG1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014
Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012
LKB1 regulates TCR-mediated PLC gamma 1 activation and thymocyte positive selection, EMBO JOURNAL, 2011
p300-Mediated Acetylation Stabilizes the Th-Inducing POK Factor, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, 2010
Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition, NATURE IMMUNOLOGY, 2008

Immunology: Immune Cells Differentiation Function Immune Response T Cells B Cells Nk Cells Cytokines Immunotherapy Inflammation Cell Biology: Cell Structure Cell Function Cell Signaling Cell Differentiation Cell Cycle Apoptosis Stem Cells Cellular Metabolism Organelles Cell Communication

Chunling Wan - Shanghai Jiao Tong University

Huiwen Yan - Central South University

Jun Huang - Zhejiang University

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