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Jizhong Lou
Life Science
University of Chinese Academy of Sciences
Beijing
Language: Chinese, English
Tumor
Immune
Regulation
T Cell
Mechanobiology
Signal Transduction
Single-Molecule
Biophysics
Molecular Dynamics
Simulation
Areas of Focus
- Tumor immune recognition and regulation
- T cell functional modification
- Mechanobiology
- Transmembrane signal transduction
- Single-molecule biophysics
- Molecular dynamics simulation
Work Experience
- 2009-10~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher, Group Leader
- 2005-08~2009-09 - Georgia Institute of Technology - Research Assistant Professor
- 2001-10~2005-07 - Georgia Institute of Technology - Postdoctoral
- 2000-10~2001-09 - University of Nevada, Las Vegas - Postdoctoral
Academic Background & Achievements
- 1997-09--2000-08 PhD: Institute of Theoretical Physics, Chinese Academy of Sciences
- 1994-09--1997-07 Master's: Peking University
- 1990-10--1994-07 Bachelor's: Jilin University
Publications
- GxcM-Fbp17/RacC-WASP signaling regulates polarized cortex assembly in migrating cells via Arp2/3, Dong Li, Yihong Yang, Chenglin Lv, Yingjie Wang, Xiaoting Chao, Jiafeng Huang, Shashi P. Singh, Ye Yuan, Chengyu Zhang, Jizhong Lou, Pu Gao, Shanjin Huang, Bo Li, Huaqing Cai, 2023
- Self-programmed dynamics of T cell receptor condensation, Chen, Hui, Xu, Xinyi, Hu, Wei, Wu, Songfang, Xiao, Jianhui, Wu, Peng, Wang, Xiaowen, Han, Xuling, Zhang, Yanruo, Zhang, Yong, Jiang, Ning, Liu, Wanli, Lou, Changjie, Chen, Wei, Xu, Chenqi, Lou, Jizhong, 2023
- Catch bond models may explain how force amplifies TCR signaling and antigen discrimination, Choi, HyunKyu, Cong, Peiwen, Ge, Chenghao, Natarajan, Aswin, Liu, Baoyu, Zhang, Yong, Li, Kaitao, Rushdi, Muaz Nik, Chen, Wei, Lou, Jizhong, Krogsgaard, Michelle, Zhu, Cheng, 2023
- Structure of Arabidopsis SOQ1 lumenal region unveils C-terminal domain essential for negative regulation of photoprotective qH, Yu, Guimei, Hao, Jingfang, Pan, Xiaowei, Shi, Lifang, Zhang, Yong, Wang, Jifeng, Fan, Hongcheng, Xiao, Yang, Yang, Fuquan, Lou, Jizhong, Chang, Wenrui, Malnoe, Alizee, Li, Mei, 2022
- Essence determines phenomenon: Assaying the material properties of biological condensates, Wang, Z., Lou, J., Zhang, H., 2022
- CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma, Chen, Yiran, Li, Li, Lan, Jie, Cui, Yang, Rao, Xiaosong, Zhao, Jing, Xing, Tao, Ju, Gaoda, Song, Guangtao, jlou@ibp.ac.cn, Liang, Jun, 2022
- NKG2D discriminates diverse ligands through selectively mechano-regulated ligand conformational changes, Fan, Juan, Shi, Jiawei, Zhang, Yong, Liu, Junwei, An, Chenyi, Zhu, Huaying, Wu, Peng, Hu, Wei, Qin, Rui, Yao, Danmei, Shou, Xin, Xu, Yibing, Tong, Zhou, Wen, Xue, Xu, Jianpo, Zhang, Jin, Fang, Weijia, Lou, Jizhong, Yin, Weiwei, Chen, Wei, 2022
- Mechanical activation of spike fosters SARS-CoV-2 infection (Aug, 10.1038/s41422-021-00576-9, 2021), Hu, Wei, Zhang, Yong, Fei, Panyu, Zhang, Tongtong, Yao, Danmei, Gao, Yufei, Liu, Jia, Chen, Hui, Lu, Qiao, Mudianto, Tenny, Zhang, Xinrui, Xiao, Chuxuan, Ye, Yang, Sun, Qiming, Zhang, Jing, Xie, Qi, Wang, PeiHui, Wang, Jun, Li, Zhenhai, Lou, Jizhong, Chen, Wei, 2021
- 新冠病毒入侵与免疫防御的分子力学生物学研究进展, 胡炜, 秦瑞, 张勇, 武鹏, 费攀宇, 张同同, 安宸毅, 尹巍巍, 李振海, 娄继忠, 陈伟, 2021
- 机械力调控的PD-1信号通路, 陈辉, 崔蕾, 宋广涛, 娄继忠, 2021
- 神经突触后膜蛋白Neuroligin-1的力-电感知及其耦合调控分子机制的研究, 胡炜, 安辰毅, 张同同, 廖泰霖, 刘俊伟, 张勇, 欧阳波, 娄继忠, 许均瑜, 陈伟, 2021
- CD8选择性利用生物力增强TCR抗原识别的灵敏度和鲁棒性, 秦瑞, 武鹏, 施佳未, 张勇, 娄继忠, 尹巍巍, 陈伟, 2021
- Mechanical unfolding of a beta-barrel membrane protein by single-molecule force spectroscopy, Chen, Hui, Song, Guangtao, Zhang, Yong, Ni, Dongchun, Zhang, Xinwei, Huang, Yihua, Lou, Jizhong, 2021
- Mechanical activation of spike fosters SARS-CoV-2 viral infection, Hu, Wei, Zhang, Yong, Fei, Panyu, Zhang, Tongtong, Yao, Danmei, Gao, Yufei, Liu, Jia, Chen, Hui, Lu, Qiao, Mudianto, Tenny, Zhang, Xinrui, Xiao, Chuxuan, Ye, Yang, Sun, Qiming, Zhang, Jing, Xie, Qi, Wang, PeiHui, Wang, Jun, Li, Zhenhai, Lou, Jizhong, Chen, Wei, 2021
- Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases, Zhang, Hong, Ji, Xiong, Li, Pilong, Liu, Cong, Lou, Jizhong, Wang, Zheng, Wen, Wenyu, Xiao, Yue, Zhang, Mingjie, Zhu, Xueliang, 2020
- Protein Databases Related to Liquid-Liquid Phase Separation, Li, Qian, Wang, Xi, Dou, Zhihui, Yang, Weishan, Huang, Beifang, Lou, Jizhong, Zhang, Zhuqing, 2020
- Liquid-liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA, Chen, Hui, Cui, Yang, Han, Xuling, Hu, Wei, Sun, Min, Zhang, Yong, Wang, PeiHui, Song, Guangtao, Chen, Wei, Lou, Jizhong, 2020
- Preparation of DNA Origami for Ordered Immobilization of Single Molecules on Diamond Surface, Wei YiCheng, Yu Pei, Chen Ming, Sun ZiTing, Zeng Yan, Lou JiZhong, Chen SanYou, Shi FaZhan, Du JiangFeng, 2020
- Conformational activation of ribosome recycling by intra- and inter-molecular dynamics of RRF, Song, Guangtao, Xu, Benjin, Shi, Huigang, Zhang, Yong, Zhang, Dejiu, Cao, Xintao, Liu, Zengrui, Guo, Ran, Guan, YanZhong, Chu, Yanhui, Zhang, Xinzheng, Lou, Jizhong, Qin, Yan, 2020
- 用于金刚石表面单分子有序固定的DNA折纸制备, 魏一成, 余佩, 陈明, 孙梓庭, 曾俨, 娄继忠, 陈三友, 石发展, 杜江峰, 2020
- Direct observation of the formation of a CRISPR-Cas12a R-loop complex at the single-molecule level, Cui, Yang, Tang, Yangchao, Liang, Meng, Ji, Qinghua, Zeng, Yan, Chen, Hui, Lan, Jie, Jin, Peng, Wang, Lei, Song, Guangtao, Lou, Jizhong, 2020
- Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress, Yu, Jiaojiao, Li, Tao, Liu, Yu, Wang, Xi, Zhang, Jianchao, Wang, Xie, Shi, Guizhi, Lou, Jizhong, Wang, Likun, Wang, Chihchen, VVang, Lei, 2020
- Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition, Wu, Peng, Zhang, Tongtong, Liu, Baoyu, Fei, Panyu, Cui, Lei, Qin, Rui, Zhu, Huaying, Yao, Danmei, Martinez, Ryan J, Hu, Wei, An, Chenyi, Zhang, Yong, Liu, Junwei, Shi, Jiawei, Fan, Juan, Yin, Weiwei, Sun, Jie, Zhou, Chun, Zeng, Xun, Xu, Chenqi, Wang, Jianan, Evavold, Brian D, Zhu, Cheng, Chen, Wei, Lou, Jizhong, 2019
- Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains, Huang, Yuwei, Zucker, Ben, Zhang, Shaojin, Elias, Sharon, Zhu, Yun, Chen, Hui, Ding, Tianlun, Li, Ying, Sun, Yujie, Lou, Jizhong, Kozlov, Michael M, Yu, Li, 2019
- Conformational Dynamics, Intramolecular Domain Conformation Signaling, and Activation of Apo-FimD Revealed by Single-Molecule Fluorescence Resonance Energy Transfer Studies, Liu, Yanqing, Sun, Chuanqi, Han, Long, Yu, Yuqi, Zhou, Haizhen, Shao, Qiang, Lou, Jizhong, Zhao, Yongfang, Huang, Yihua, 2019
- Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States, Sun, Wei, Yang, Jing, Cheng, Zhi, Amrani, Nadia, Liu, Chao, Wang, Kangkang, Ibraheim, Raed, Edraki, Alireza, Huang, Xue, Wang, Min, Wang, Jiuyu, Liu, Liang, Sheng, Gang, Yang, Yanhua, Lou, Jizhong, Sontheimer, Erik J, Wang, Yanli, 2019
- Mechanosensing through immunoreceptors, Zhu, Cheng, Chen, Wei, Lou, Jizhong, Rittase, William, Li, Kaitao, 2019
- A thiazole-derived oridonin analogue exhibits antitumor activity by directly and allosterically inhibiting STAT3, Shen, Xiaofei
