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Sheng Ye
Life Science
Zhejiang University
Zhejiang
Language: Chinese, English
Ftsz
Gtp Hydrolysis
Constrictive Force
Cell Division
Molecular Dynamics
Protein Structure
Bacterial Cytokinesis
Mechanical Force
Membrane Interaction
Protein Interaction
Ion Selectivity
Potassium Channels
Sodium Ions
Channel Gating
Molecular Structure
Biophysics
Electrophysiology
Ion Transport
Protein Engineering
Channel Dynamics
Areas of Focus
- Molecular mechanisms of Z-ring contraction in bacterial cell division
- Molecular mechanisms of anomalous mole-fraction effect in potassium ion channels
Work Experience
- 2001-2003 Scientist at Syrrx, USA
- 2003-2005 Scientist at Texas A&M Health Science Center, USA
- 2005-2010 Lecturer, Research Specialist Level II, Assistant Professor at University of Texas Southwestern Medical Center/Howard Hughes Medical Institute, USA
- 2010-2014 Professor, Researcher at Zhejiang University, Life Sciences Institute
- 2015-present Professor, Senior Researcher at Zhejiang University, Life Sciences Institute
Academic Background & Achievements
- 1987-1991 Bachelor in Cell Biology: Xiamen University
- 1991-1996 PhD in Biophysics: Institute of Biophysics, Chinese Academy of Sciences
- 1996-1999 Postdoctoral Fellow in Biochemistry: Baylor College of Medicine
- 1999-2001 Postdoctoral Fellow in Biochemistry: University of Texas Southwestern Medical Center
Publications
- A Rational Approach to Enhancing Antibody Fc Homodimer Formation for Robust Production of Antibody Mixture in a Single Cell Line, Jie Yu, Xiaoxiao Wang, Tao Xu, Qiuheng Jin, Jinyuan Duan, Jie Wu, Haiyan Wu, Ting Xu, Sheng Ye, 2017
- Ionic interactions of Ba2+ blockades in the MthK K+ channel, Guo R, Zeng W, Cui HJ, Chen L, Ye S, 2014
- FtsZ Protofilaments use a hinge-opening mechanism for constrictive force generation, Li Y, Hsin J, Zhao L, Cheng Y, Shang W, Huang KC, Wang HW, Ye S, 2013
- Structural Basis of Heparan Sulfate-Specific Degradation by Heparinase III, Dong W, Lu W, McKeehan WL, Luo Y, Ye S, 2012
- Novel insights into ion selectivity from high resolution structures of an open K+ channel pore, Ye S, Li Y, Chen L, Jiang Y, 2010
- Crystal structures of a Ligand-free MthK gating ring: Insights into the ligand gating mechanism of K+ channel, Ye S, Li Y, Chen L, Jiang Y, 2006
Awards
- 2010 Zhejiang Province Outstanding Youth Fund recipient
- 2010 Ministry of Education New Century Excellent Talents Support Plan
- 2015 National Outstanding Youth Fund recipient
- 2016 Qiushi Distinguished Professor at Zhejiang University
