Professor | Shiwu Li | Asia Growth Partners

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Name	Shiwu Li
Contact Information	lishiwu@mail.kiz.ac.cn
Language ability	Chinese, English
Province	Yunnan

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Name

Shiwu Li

Contact Information

lishiwu@mail.kiz.ac.cn

Language ability

Chinese, English

Province

Yunnan

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2017-09 to 2021-01 PhD: Kunming Institute of Zoology, Chinese Academy of Sciences 2012-09 to 2015-06 Master's: Kunming University of Science and Technology 2008-09 to 2012-06 Bachelor's: Xiangnan University
Work Experience	2021-04 to Present - Kunming Institute of Zoology, Chinese Academy of Sciences - Associate Researcher 2021-01 to 2021-04 - Kunming Institute of Zoology, Chinese Academy of Sciences - Assistant Researcher 2015-09 to 2017-08 - Kunming Institute of Zoology, Chinese Academy of Sciences - Research Intern

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2017-09 to 2021-01 PhD: Kunming Institute of Zoology, Chinese Academy of Sciences
2012-09 to 2015-06 Master's: Kunming University of Science and Technology
2008-09 to 2012-06 Bachelor's: Xiangnan University

Work Experience

2021-04 to Present - Kunming Institute of Zoology, Chinese Academy of Sciences - Associate Researcher
2021-01 to 2021-04 - Kunming Institute of Zoology, Chinese Academy of Sciences - Assistant Researcher
2015-09 to 2017-08 - Kunming Institute of Zoology, Chinese Academy of Sciences - Research Intern

Areas of Focus	Animal Models of Mental Disorders High-Altitude Hypoxia and Brain Health
Publications	Genomic landscape and functional characterization of structural variations in schizophrenia and bipolar disorder, Corresponding Author, 2024 Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice, 9th Author, 2023 Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function, 10th Author, 2023 The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density, 1st Author, 2022 Regulatory variants at 2q33.1 confer schizophrenia risk by modulating distal gene TYW5 expression, 1st Author, 2022 Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1, 2nd Author, 2022 Genetic regulatory and biological implications of the 10q24.32 schizophrenia risk locus, 3rd Author, 2022 A functional population-specific variant rs77416373 in the CaV2.1 gene is associated with antidepressant treatment response in Han Chinese subjects with major depressive disorder, 3rd Author, 2022 Functional genomics elucidates regulatory mechanisms of Parkinson's disease-associated variants, 3rd Author, 2022 Regulatory Variant rs2535629 in ITIH3 Intron Confers Schizophrenia Risk By Regulating CTCF Binding and SFMBT1 Expression, 3rd Author, 2022 A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression, 8th Author, 2021 Functional variants fine-mapping and gene function characterization provide insights into the role of ZNF323 in schizophrenia pathogenesis, 1st Author, 2021 Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia, 2nd Author, 2021 Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene, 2nd Author, 2021 The schizophrenia susceptibility gene NAGA regulates dendritic spine density: further evidence for the dendritic spine pathology of schizophrenia, 2nd Author, 2021 A functional missense variant in ITIH3 affects protein expression and neurodevelopment and confers schizophrenia risk in the Han Chinese population, 6th Author, 2020 Regulatory mechanisms of major depressive disorder risk variants, 1st Author, 2020 The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population, 8th Author, 2019 Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder, 2nd Author, 2019 Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk, 2nd Author, 2019

Areas of Focus

Animal Models of Mental Disorders
High-Altitude Hypoxia and Brain Health

Publications

Genomic landscape and functional characterization of structural variations in schizophrenia and bipolar disorder, Corresponding Author, 2024
Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice, 9th Author, 2023
Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function, 10th Author, 2023
The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density, 1st Author, 2022
Regulatory variants at 2q33.1 confer schizophrenia risk by modulating distal gene TYW5 expression, 1st Author, 2022
Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1, 2nd Author, 2022
Genetic regulatory and biological implications of the 10q24.32 schizophrenia risk locus, 3rd Author, 2022
A functional population-specific variant rs77416373 in the CaV2.1 gene is associated with antidepressant treatment response in Han Chinese subjects with major depressive disorder, 3rd Author, 2022
Functional genomics elucidates regulatory mechanisms of Parkinson's disease-associated variants, 3rd Author, 2022
Regulatory Variant rs2535629 in ITIH3 Intron Confers Schizophrenia Risk By Regulating CTCF Binding and SFMBT1 Expression, 3rd Author, 2022
A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression, 8th Author, 2021
Functional variants fine-mapping and gene function characterization provide insights into the role of ZNF323 in schizophrenia pathogenesis, 1st Author, 2021
Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia, 2nd Author, 2021
Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene, 2nd Author, 2021
The schizophrenia susceptibility gene NAGA regulates dendritic spine density: further evidence for the dendritic spine pathology of schizophrenia, 2nd Author, 2021
A functional missense variant in ITIH3 affects protein expression and neurodevelopment and confers schizophrenia risk in the Han Chinese population, 6th Author, 2020
Regulatory mechanisms of major depressive disorder risk variants, 1st Author, 2020
The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population, 8th Author, 2019
Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder, 2nd Author, 2019
Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk, 2nd Author, 2019

Mental Disorders Animal Models Schizophrenia Depression Bipolar Disorder Neuroscience Genetics Brain Health Hypoxia High-Altitude

Zhengmao Hu - Central South University

Ma Long - Central South University

Xu Jinghong - East China Normal University

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