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Gonghua Li
ligonghua@mail.kiz.ac.cn
Chinese, English
Yunnan
University of Chinese Academy of Sciences
Life Sciences
  • 2003-09 to 2009-07 PhD: Kunming Institute of Zoology, Chinese Academy of Sciences
  • 1999-09 to 2003-07 Bachelor's: Wuhan Polytechnic University
  • 2015-07 to Present - Kunming Institute of Zoology, Chinese Academy of Sciences - Associate Researcher
  • 2014-06 to 2015-07 - Massachusetts General Hospital, Harvard Medical School - Visiting Scholar
  • 2009-07 to 2014-07 - Kunming Institute of Zoology, Chinese Academy of Sciences - Assistant Researcher
Development of the iHuman system for disease mechanism and drug design
Study of molecular mechanisms of aging and age-related diseases using multi-omics data
Integration of bioinformatics and chemoinformatics for drug design targeting complex diseases
  • Metabolic Modeling Identifies a Novel Molecular Type of Glioblastoma Associated with Good Prognosis, Shen, Qiu, Yang, Hua, Kong, QingPeng, Li, GongHua, Li, Li, 2023
  • Screening of antibacterial compounds with novel structure from the FDA approved drugs using machine learning methods, WenXing Li, Xin Tong, PengPeng Yang, Yang Zheng, JiHao Liang, GongHua Li, Dahai Liu, DaoGang Guan, ShaoXing Dai, 2022
  • Specific Gain and Loss of Co-Expression Modules in Long-Lived Individuals Indicate a Role of circRNAs in Human Longevity, Ge, Mingxia, Jiang, Jianjun, Yang, Liqin, Yang, Xingli, He, Yonghan, Li, Gonghua, Kong, Qingpeng, 2022
  • System-level metabolic modeling facilitates unveiling metabolic signature in exceptional longevity, Li, GongHua, Han, Feifei, Xiao, FuHui, Gu, KangSuYun, Shen, Qiu, Xu, Weihong, Li, WenXing, Wang, YanLi, Liang, Bin, Huang, JingFei, Xiao, Wenzhong, Kong, QingPeng, 2022
  • Multiple time-series expression trajectories imply dynamic functional changes during cellular senescence, Ge, MingXia, Yu, Qin, Li, GongHua, Yang, LiQin, He, Yonghan, Li, Ji, Kong, QingPeng, 2022
  • Mechanism of Thymus Rejuvenation in Elderly Macaques, Wang, YanYing, Chang, Le, Zhu, GaoHong, Li, GongHua, Kong, QingPeng, Lv, LongBao, Wang, Qiang, Tian, Chuan, Li, Ye, Zhu, XiangQing, Pan, XingHua, 2022
  • Systematic metabolic analysis of potential target, therapeutic drug, diagnostic method and animal model applicability in three neurodegenerative diseases, Li, WenXing, Li, GongHua, Tong, Xin, Yang, PengPeng, Huang, JingFei, Xu, Lin, Dai, ShaoXing, 2020
  • Glycerophosphodiester phosphodiesterase 1 (GDE1) acts as a potential tumor suppressor and is a novel therapeutic target for non-mucin-producing colon adenocarcinoma, Shen, Qiu, Lu, Chao, Yang, Hua, Ge, MingXia, Xia, WangXiao, Kong, QingPeng, Li, GongHua, Gu, YanHong, 2020
  • Identification of DNA N-6-methyladenine sites by integration of sequence features, Wang, Hao-Tian, Xiao, Fu-Hui, Li, Gong-Hua, Kong, Qing-Peng, 2020
  • FastMM: an efficient toolbox for personalized constraint-based metabolic modeling, Li, GongHua, Dai, Shaoxing, Han, Feifei, Li, Wenxin, Huang, Jingfei, Xiao, Wenzhong, 2020
  • Identification of four hub genes associated with adrenocortical carcinoma progression by WGCNA, Xia, Wang-Xiao, Yu, Qin, Li, Gong-Hua, Liu, Yao-Wen, Xiao, FuHui, Yang, Li-Qin, Rahman, Zia Ur, Wang, Hao-Tian, Kong, Qing-Peng, 2019
  • Low expression of aging-related NRXN3 is associated with Alzheimer disease A systematic review and meta-analysis, Zheng, JunJuan, Li, WenXing, Liu, JiaQian, Guo, YiCheng, Wang, Qian, Li, GongHua, Dai, ShaoXing, Huang, JingFei, 2018
  • Subcellular stoichiogenomics reveal cell evolution and electrostatic interaction mechanisms in cytoskeleton, Zhang, YuJuan, Zhu, Chengxu, Ding, Yiran, Yan, ZhengWen, Li, GongHua, Lan, Yang, Wen, JianFan, Chen, Bin, 2018
  • A strategy to find novel candidate anti-Alzheimer's disease drugs by constructing interaction networks between drug targets and natural compounds in medical plants, Chen, BiWen, Li, WenXing, Wang, GuangHui, Li, GongHua, Liu, JiaQian, Zheng, JunJuan, Wang, Qian, Li, HuiJuan, Dai, ShaoXing, Huang, JingFei, 2018
  • Identification of metabolism-associated genes and pathways involved in different stages of clear cell renal cell carcinoma, Li, HuiJuan, Li, WenXing, Dai, ShaoXing, Guo, YiCheng, Zheng, JunJuan, Liu, JiaQian, Wang, Qian, Chen, BiWen, Li, GongHua, Huang, JingFei, 2018
  • A new method of identifying glioblastoma subtypes and creation of corresponding animal models, Zhou, Xia, Li, Gonghua, An, Sanqi, Li, WenXing, Yang, Huihui, Guo, Yicheng, Dai, Zhi, Dai, Shaoxing, Zheng, Junjuan, Huang, Jingfei, Iavarone, Antonio, Zhao, Xudong, 2018
  • Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets, Li, WenXing, He, Kan, Tang, Ling, Dai, ShaoXing, Li, GongHua, Lv, WenWen, Guo, YiCheng, An, SanQi, Wu, GuoYing, Liu, Dahai, Huang, JingFei, 2017
  • The identification and molecular mechanism of anti-stroke traditional Chinese medicinal compounds, Liu, JiaQian, Dai, ShaoXing, Zheng, JunJuan, Guo, YiCheng, Li, WenXing, Li, GongHua, Huang, JingFei, 2017
  • Folate Deficiency and Gene Polymorphisms of MTHFR,MTR and MTRR Elevate the Hyperhomocysteinemia Risk, Li, WenXing, Cheng, Fei, Zhang, AJie, Dai, ShaoXing, Li, GongHua, Lv, WenWen, Zhou, Tao, Zhang, Qiang, Zhang, Hong, Zhang, Tao, Liu, Fang, Liu, Dahai, Huang, JingFei, 2017
  • Different impairment of immune and inflammation functions in short and long-term after ischemic stroke, Li, WenXing, Qi, Fei, Liu, JiaQian, Li, GongHua, Dai, ShaoXing, Zhang, Tao, Cheng, Fei, Liu, Dahai, Zheng, Song Guo, 2017
  • Meta-Analysis of Parkinson's Disease and Alzheimer's Disease Revealed Commonly Impaired Pathways and Dysregulation of NRF2-Dependent Genes, Wang, Qian, Li, WenXing, Dai, ShaoXing, Guo, YiCheng, Han, FeiFei, Zheng, JunJuan, Li, GongHua, Huang, JingFei, 2017
  • Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets, Li, WenXing, Dai, ShaoXing, Wang, Qian, Guo, YiCheng, Hong, Yi, Zheng, JunJuan, Liu, JiaQian, Liu, Dahai, Li, GongHua, Huang, JingFei, 2016
  • Integrated Analysis of Alzheimer's Disease and Schizophrenia Dataset Revealed Different Expression Pattern in Learning and Memory, Li, WenXing, Dai, ShaoXing, Liu, JiaQian, Wang, Qian, Li, GongHua, Huang, JingFei, 2016
  • In silico identification of anti-cancer compounds and plants from traditional Chinese medicine database, Dai, ShaoXing, Li, WenXing, Han, FeiFei, Guo, YiCheng, Zheng, JunJuan, Liu, JiaQian, Wang, Qian, Gao, YueDong, Li, GongHua, Huang, JingFei, 2016
  • Proteome-wide prediction of targets for aspirin: new insight into the molecular mechanism of aspirin, Dai, ShaoXing, Li, WenXing, Li, GongHua, Huang, JingFei, 2016
  • Integrated Analysis of Residue Coevolution and Protein Structures Capture Key Protein Sectors in HIV-1 Proteins, Zhao, Yuqi, Wang, Yanjie, Gao, Yuedong, Li, Gonghua, Huang, Jingfei, 2015
  • Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals, Liu, Zhen, Wang, Wei, Zhang, TongZuo, Li, GongHua, He, Kai, Huang, JingFei, Jiang, XueLong, Murphy, Robert W, Shi, Peng, 2014
  • Inferring therapeutic targets from heterogeneous data: HKDC1 is a novel potential therapeutic target for cancer, Li, GongHua, Huang, JingFei, 2014
  • CDRUG: a web server for predicting anticancer activity of chemical compounds, Li, GongHua, Huang, JingFei, 2012
  • MOfinder: A Novel Algorithm for Detecting Overlapping Modules from Protein-Protein Interaction Network, Yu, Qi, Li, GongHua, Huang, JingFei, 2012
  • Hearing Aid for Vertebrates via Multiple Episodic Adaptive Events on Prestin Genes, Liu, Zhen, Li, GongHua, Huang, JingFei, Murphy, Robert W, Shi, Peng, 2012
  • CMASA: an accurate algorithm for detecting local protein structural similarity and its application to enzyme catalytic site annotation, Li, GongHua, Huang, JingFei, 2010
Ihuman Disease Mechanism Drug Design Multi-Omics Aging Bioinformatics Chemoinformatics Complex Diseases Gene Knockout Drug Screening

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