Professor | Xin Li | Asia Growth Partners

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Name	Xin Li
Contact Information	lixin@sinh.ac.cn
Language ability	English, Chinese
Province	Shanghai

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Name

Xin Li

Contact Information

lixin@sinh.ac.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2005-08 to 2010-01 - Ph.D.: Case Western Reserve University 2001-09 to 2005-07 - Bachelor's: Tsinghua University
Work Experience	2020-04 to Present - Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health - Researcher 2019-02 to 2020-04 - Chinese Academy of Sciences, Shanghai Institute of Life Sciences - Researcher 2016-05 to 2019-02 - Stanford University - Assistant Researcher 2012-01 to 2016-05 - Stanford University - Postdoctoral Researcher 2010-01 to 2011-12 - Case Western Reserve University - Postdoctoral Researcher 2005-08 to 2010-01 - Case Western Reserve University - Ph.D. Student 2001-09 to 2005-07 - Tsinghua University - Bachelor's Student
Awards	C. W. Cotterman Award (2015): National Level, Special Prize

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2005-08 to 2010-01 - Ph.D.: Case Western Reserve University
2001-09 to 2005-07 - Bachelor's: Tsinghua University

Work Experience

2020-04 to Present - Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health - Researcher
2019-02 to 2020-04 - Chinese Academy of Sciences, Shanghai Institute of Life Sciences - Researcher
2016-05 to 2019-02 - Stanford University - Assistant Researcher
2012-01 to 2016-05 - Stanford University - Postdoctoral Researcher
2010-01 to 2011-12 - Case Western Reserve University - Postdoctoral Researcher
2005-08 to 2010-01 - Case Western Reserve University - Ph.D. Student
2001-09 to 2005-07 - Tsinghua University - Bachelor's Student

Awards

C. W. Cotterman Award (2015): National Level, Special Prize

Areas of Focus	Computational Biology - Human Genetic Variation, Machine Learning and Artificial Intelligence Methods Based on Multi-Omics Big Data
Publications	Whole genome sequencing enables new genetic diagnosis for inherited retinal diseases by identifying pathogenic variants, 11th Author, 2024 Complex clinical manifestations and new insights in RNA sequencing of children with diabetes and WFS1 variants, 7th Author, 2023 An RNA-informed dosage sensitivity map reflects the intrinsic functional nature of genes, 11th Author, 2023 Active DHEA uptake in the prostate gland correlates with aggressive prostate cancer, 11th Author, 2023 Integration of rare expression outlier-associated variants improves polygenic risk prediction, 10th Author, 2022 The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice, 2nd Author, 2021 Identification of rare and common regulatory variants in pluripotent cells using population-scale transcriptomics, 7th Author, 2021 Transcriptomic signatures across human tissues identify functional rare genetic variation, 32nd Author, 2020 Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts, 5th Author, 2019 Genetic analyses of human fetal retinal pigment epithelium gene expression suggest ocular disease mechanisms, 8th Author, 2019 Genetic regulation of gene expression and splicing during a 10-year period of human aging, 5th Author, 2019 The impact of structural variation on human gene expression, 5th Author, 2017 The impact of rare variation on gene expression across tissues, 1st Author, 2017 Population and individual effects of non-coding variants inform genetic risk factors., 4th Author, 2017 Genetic conflict reflected in tissue-specific maps of genomic imprinting in human and mouse, 5th Author, 2015 Quantifying RNA allelic ratios by microfluidic multiplex PCR and sequencing, 2nd Author, 2014 Transcriptome Sequencing of a Large Human Family Identifies the Impact of Rare Noncoding Variants, 11th Author, 2014 Haplotype Reconstruction in Large Pedigrees with Untyped Individuals through IBD Inference, 1st Author, 2011 Efficient identification of identical-by-descent status in pedigrees with many untyped individuals, 1st Author, 2010 AN ALMOST LINEAR TIME ALGORITHM FOR A GENERAL HAPLOTYPE SOLUTION ON TREE PEDIGREES WITH NO RECOMBINATION AND ITS EXTENSIONS, 1st Author, 2009 EFFICIENT HAPLOTYPE INFERENCE FROM PEDIGREES WITH MISSING DATA USING LINEAR SYSTEMS WITH DISJOINT-SET DATA STRUCTURES, 1st Author, 2008

Areas of Focus

Computational Biology - Human Genetic Variation, Machine Learning and Artificial Intelligence Methods Based on Multi-Omics Big Data

Publications

Whole genome sequencing enables new genetic diagnosis for inherited retinal diseases by identifying pathogenic variants, 11th Author, 2024
Complex clinical manifestations and new insights in RNA sequencing of children with diabetes and WFS1 variants, 7th Author, 2023
An RNA-informed dosage sensitivity map reflects the intrinsic functional nature of genes, 11th Author, 2023
Active DHEA uptake in the prostate gland correlates with aggressive prostate cancer, 11th Author, 2023
Integration of rare expression outlier-associated variants improves polygenic risk prediction, 10th Author, 2022
The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice, 2nd Author, 2021
Identification of rare and common regulatory variants in pluripotent cells using population-scale transcriptomics, 7th Author, 2021
Transcriptomic signatures across human tissues identify functional rare genetic variation, 32nd Author, 2020
Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts, 5th Author, 2019
Genetic analyses of human fetal retinal pigment epithelium gene expression suggest ocular disease mechanisms, 8th Author, 2019
Genetic regulation of gene expression and splicing during a 10-year period of human aging, 5th Author, 2019
The impact of structural variation on human gene expression, 5th Author, 2017
The impact of rare variation on gene expression across tissues, 1st Author, 2017
Population and individual effects of non-coding variants inform genetic risk factors., 4th Author, 2017
Genetic conflict reflected in tissue-specific maps of genomic imprinting in human and mouse, 5th Author, 2015
Quantifying RNA allelic ratios by microfluidic multiplex PCR and sequencing, 2nd Author, 2014
Transcriptome Sequencing of a Large Human Family Identifies the Impact of Rare Noncoding Variants, 11th Author, 2014
Haplotype Reconstruction in Large Pedigrees with Untyped Individuals through IBD Inference, 1st Author, 2011
Efficient identification of identical-by-descent status in pedigrees with many untyped individuals, 1st Author, 2010
AN ALMOST LINEAR TIME ALGORITHM FOR A GENERAL HAPLOTYPE SOLUTION ON TREE PEDIGREES WITH NO RECOMBINATION AND ITS EXTENSIONS, 1st Author, 2009
EFFICIENT HAPLOTYPE INFERENCE FROM PEDIGREES WITH MISSING DATA USING LINEAR SYSTEMS WITH DISJOINT-SET DATA STRUCTURES, 1st Author, 2008

Computational Biology Human Genetic Variation Machine Learning Artificial Intelligence Multi-Omics Big Data Genomics Bioinformatics Genetic Research Data Analysis

Yong Zhang - Tongji University

Lu Lu Gong - Tongji University

Guohui Chuai - Tongji University

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