Areas of Focus
- Microbial Genetics
- Drug Development
Work Experience
- 2019-05~2021-08 - University of North Carolina at Chapel Hill - Assistant Professor
- 2016-06~2019-04 - University of North Carolina at Chapel Hill - Postdoctoral Researcher
- 2016-01~2016-05 - Pennsylvania State University - Postdoctoral Researcher
- 2011-07~2016-01 - Institute of Microbiology, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2005-09--2011-07 PhD: University of Chinese Academy of Sciences
- 2001-09--2005-07 Bachelor: Harbin Institute of Technology
Publications
- An efficient method for targeted cloning of large DNA fragments from Streptomyces, Appl Microbiol Biotechnol, 2023
- Chemoenzymatic Synthesis of Homogeneous Heparan Sulfate and Chondroitin Sulfate Chimeras, ACS CHEMICAL BIOLOGY, 2022
- A visualization reporter system for characterizing antibiotic biosynthetic gene clusters expression with high-sensitivity, COMMUNICATIONS BIOLOGY, 2022
- Chemical, Molecular, and Single-nucleus Analysis Reveal Chondroitin Sulfate Proteoglycan Aberrancy in Fibrolamellar Carcinoma, CANCER RESEARCH COMMUNICATIONS, 2022
- Molecular mechanism of mureidomycin biosynthesis activated by introduction of an exogenous regulatory gene ssa A into Streptomyces roseosporus, SCIENCE CHINA-LIFE SCIENCES, 2021
- Characterization of a 3-hydroxyanthranilic acid 6-hydroxylase involved in paulomycin biosynthesis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021
- Construction of an Alternative NAD(+) De Novo Biosynthesis Pathway, ADVANCED SCIENCE, 2021
- Enzymatic Synthesis of Chondroitin Sulfate E to AttenuateBacteria Lipopolysaccharide-Induced Organ Damage, ACS CENTRAL SCIENCE, 2020
- Using heparin molecules to manage COVID-2019, RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, 2020
- Improvement of Paulomycin Stability by Addition of Paulic Acid, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018
- Discovery of pentangular polyphenols hexaricins A-C from marine Streptosporangium sp CGMCC 4.7309 by genome mining, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2016
- Progress in streptothricin antibiotics - A review, 微生物学报, 2016
- Involvement of an octose ketoreductase and two acyltransferases in the biosynthesis of paulomycins, SCIENTIFIC REPORTS, 2016
- Biosynthesis of the Carbamoylated D-Gulosamine Moiety of Streptothricins: Involvement of a Guanidino-N-glycosyltransferase and an N-Acetyl-D-gulosamine Deacetylase, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015
- Identification and Analysis of the Paulomycin Biosynthetic GeneCluster and Titer Improvement of the Paulomycins in Streptomycespaulus NRRL 8115, PLOS ONE, 2015
- An efficient blue-white screening based gene inactivation system for Streptomyces, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2015
- Engineering and heterologous expression of a nikkomycin biosynthetic gene cluster, 微生物学报, 2015
- Mining of a streptothricin gene cluster from Streptomyces sp.TP-A0356 genome via heterologous expression, SCIENCE CHINA-LIFE SCIENCES, 2013
- Novel polyoxins generated by heterologously expressing polyoxin biosynthetic gene cluster in the sanN inactivated mutant of Streptomyces ansochromogenes, MICROBIAL CELL FACTORIES, 2012
- Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties, METABOLIC ENGINEERING, 2011
- Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production, MICROBIAL CELL FACTORIES, 2010
- Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes, MICROBIAL CELL FACTORIES, 2009
- sanN encoding a dehydrogenase is essential for nikkomycin biosynthesis in Streptomyces ansochromogenes, JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2008
