2005-09--2011-07 PhD: University of Chinese Academy of Sciences
2001-09--2005-07 Bachelor: Harbin Institute of Technology
2019-05~2021-08 - University of North Carolina at Chapel Hill - Assistant Professor
2016-06~2019-04 - University of North Carolina at Chapel Hill - Postdoctoral Researcher
2016-01~2016-05 - Pennsylvania State University - Postdoctoral Researcher
2011-07~2016-01 - Institute of Microbiology, Chinese Academy of Sciences - Assistant Researcher
Research
Microbial Genetics Drug Development
An efficient method for targeted cloning of large DNA fragments from Streptomyces, Appl Microbiol Biotechnol, 2023
Chemoenzymatic Synthesis of Homogeneous Heparan Sulfate and Chondroitin Sulfate Chimeras, ACS CHEMICAL BIOLOGY, 2022
A visualization reporter system for characterizing antibiotic biosynthetic gene clusters expression with high-sensitivity, COMMUNICATIONS BIOLOGY, 2022
Chemical, Molecular, and Single-nucleus Analysis Reveal Chondroitin Sulfate Proteoglycan Aberrancy in Fibrolamellar Carcinoma, CANCER RESEARCH COMMUNICATIONS, 2022
Molecular mechanism of mureidomycin biosynthesis activated by introduction of an exogenous regulatory gene ssa A into Streptomyces roseosporus, SCIENCE CHINA-LIFE SCIENCES, 2021
Characterization of a 3-hydroxyanthranilic acid 6-hydroxylase involved in paulomycin biosynthesis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021
Construction of an Alternative NAD(+) De Novo Biosynthesis Pathway, ADVANCED SCIENCE, 2021
Enzymatic Synthesis of Chondroitin Sulfate E to AttenuateBacteria Lipopolysaccharide-Induced Organ Damage, ACS CENTRAL SCIENCE, 2020
Using heparin molecules to manage COVID-2019, RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, 2020
Improvement of Paulomycin Stability by Addition of Paulic Acid, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018
Discovery of pentangular polyphenols hexaricins A-C from marine Streptosporangium sp CGMCC 4.7309 by genome mining, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2016
Progress in streptothricin antibiotics - A review, 微生物学报, 2016
Involvement of an octose ketoreductase and two acyltransferases in the biosynthesis of paulomycins, SCIENTIFIC REPORTS, 2016
Biosynthesis of the Carbamoylated D-Gulosamine Moiety of Streptothricins: Involvement of a Guanidino-N-glycosyltransferase and an N-Acetyl-D-gulosamine Deacetylase, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015
Identification and Analysis of the Paulomycin Biosynthetic GeneCluster and Titer Improvement of the Paulomycins in Streptomycespaulus NRRL 8115, PLOS ONE, 2015
An efficient blue-white screening based gene inactivation system for Streptomyces, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2015
Engineering and heterologous expression of a nikkomycin biosynthetic gene cluster, 微生物学报, 2015
Mining of a streptothricin gene cluster from Streptomyces sp.TP-A0356 genome via heterologous expression, SCIENCE CHINA-LIFE SCIENCES, 2013
Novel polyoxins generated by heterologously expressing polyoxin biosynthetic gene cluster in the sanN inactivated mutant of Streptomyces ansochromogenes, MICROBIAL CELL FACTORIES, 2012
Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties, METABOLIC ENGINEERING, 2011
Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production, MICROBIAL CELL FACTORIES, 2010
Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes, MICROBIAL CELL FACTORIES, 2009
sanN encoding a dehydrogenase is essential for nikkomycin biosynthesis in Streptomyces ansochromogenes, JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2008
