李金娥
lijine@im.ac.cn
中文, 英语
北京
中国科学院大学
Life Sciences
  • 2005-09--2011-07 博士: 中国科学院研究生院
  • 2001-09--2005-07 学士: 哈尔滨工业大学
  • 2019-05~2021-08 - 美国北卡大学教堂山分校 - 助理教授
  • 2016-06~2019-04 - 美国北卡大学教堂山分校 - 博士后
  • 2016-01~2016-05 - 美国宾夕法尼亚州立大学 - 博士后
  • 2011-07~2016-01 - 中国科学院微生物研究所 - 助理研究员
微生物遗传
药物研发
  • An efficient method for targeted cloning of large DNA fragments from Streptomyces, Appl Microbiol Biotechnol, 2023
  • Chemoenzymatic Synthesis of Homogeneous Heparan Sulfate and Chondroitin Sulfate Chimeras, ACS CHEMICAL BIOLOGY, 2022
  • A visualization reporter system for characterizing antibiotic biosynthetic gene clusters expression with high-sensitivity, COMMUNICATIONS BIOLOGY, 2022
  • Chemical, Molecular, and Single-nucleus Analysis Reveal Chondroitin Sulfate Proteoglycan Aberrancy in Fibrolamellar Carcinoma, CANCER RESEARCH COMMUNICATIONS, 2022
  • Molecular mechanism of mureidomycin biosynthesis activated by introduction of an exogenous regulatory gene ssa A into Streptomyces roseosporus, SCIENCE CHINA-LIFE SCIENCES, 2021
  • Characterization of a 3-hydroxyanthranilic acid 6-hydroxylase involved in paulomycin biosynthesis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021
  • Construction of an Alternative NAD(+) De Novo Biosynthesis Pathway, ADVANCED SCIENCE, 2021
  • Enzymatic Synthesis of Chondroitin Sulfate E to AttenuateBacteria Lipopolysaccharide-Induced Organ Damage, ACS CENTRAL SCIENCE, 2020
  • Using heparin molecules to manage COVID-2019, RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, 2020
  • Improvement of Paulomycin Stability by Addition of Paulic Acid, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018
  • Discovery of pentangular polyphenols hexaricins A-C from marine Streptosporangium sp CGMCC 4.7309 by genome mining, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2016
  • Progress in streptothricin antibiotics - A review, 微生物学报, 2016
  • Involvement of an octose ketoreductase and two acyltransferases in the biosynthesis of paulomycins, SCIENTIFIC REPORTS, 2016
  • Biosynthesis of the Carbamoylated D-Gulosamine Moiety of Streptothricins: Involvement of a Guanidino-N-glycosyltransferase and an N-Acetyl-D-gulosamine Deacetylase, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015
  • Identification and Analysis of the Paulomycin Biosynthetic GeneCluster and Titer Improvement of the Paulomycins in Streptomycespaulus NRRL 8115, PLOS ONE, 2015
  • An efficient blue-white screening based gene inactivation system for Streptomyces, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2015
  • Engineering and heterologous expression of a nikkomycin biosynthetic gene cluster, 微生物学报, 2015
  • Mining of a streptothricin gene cluster from Streptomyces sp.TP-A0356 genome via heterologous expression, SCIENCE CHINA-LIFE SCIENCES, 2013
  • Novel polyoxins generated by heterologously expressing polyoxin biosynthetic gene cluster in the sanN inactivated mutant of Streptomyces ansochromogenes, MICROBIAL CELL FACTORIES, 2012
  • Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties, METABOLIC ENGINEERING, 2011
  • Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production, MICROBIAL CELL FACTORIES, 2010
  • Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes, MICROBIAL CELL FACTORIES, 2009
  • sanN encoding a dehydrogenase is essential for nikkomycin biosynthesis in Streptomyces ansochromogenes, JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2008
微生物遗传: 遗传学 微生物学 Dna Rna 基因表达 突变 微生物生理学 基因工程 微生物生态学 生物信息学 药物研发: 药物 药物发现 临床试验 药理学 药物化学 生物技术 药物配方 毒理学 法规事务 药物递送

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