Professor | Honglei Ma | Asia Growth Partners

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Name	Honglei Ma
Contact Information	mahonglei@qibebt.ac.cn
Language ability	Chinese, English
Province	Shandong

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Name

Honglei Ma

Contact Information

mahonglei@qibebt.ac.cn

Language ability

Chinese, English

Province

Shandong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2014-09 to 2016-03 Joint Training: The Scripps Research Institute 2011-09 to 2016-07 Ph.D.: Shanghai Institute of Materia Medica 2005-09 to 2009-07 Bachelor's Degree: Jilin University
Work Experience	2022-05 to Present - Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology - Researcher 2021-04 to 2022-03 - Shandong University - Researcher 2018-09 to 2021-03 - Shanghai Institute of Materia Medica - Associate Researcher 2016-07 to 2018-08 - Shanghai Institute of Materia Medica - Postdoctoral Researcher 2014-09 to 2016-03 - The Scripps Research Institute - Joint Training 2010-07 to 2011-08 - ACON Biotech (Hangzhou) Co., Ltd. - Blood Glucose R&D Engineer 2009-08 to 2010-06 - Zhejiang Hisun Pharmaceutical Co., Ltd. - Drug Formulation R&D Technician
Awards	Sanofi - Chinese Academy of Sciences Shanghai Institute of Life Sciences Outstanding Young Talent Award (2020) Chinese Academy of Sciences President's Excellence Award (2016)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2014-09 to 2016-03 Joint Training: The Scripps Research Institute
2011-09 to 2016-07 Ph.D.: Shanghai Institute of Materia Medica
2005-09 to 2009-07 Bachelor's Degree: Jilin University

Work Experience

2022-05 to Present - Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology - Researcher
2021-04 to 2022-03 - Shandong University - Researcher
2018-09 to 2021-03 - Shanghai Institute of Materia Medica - Associate Researcher
2016-07 to 2018-08 - Shanghai Institute of Materia Medica - Postdoctoral Researcher
2014-09 to 2016-03 - The Scripps Research Institute - Joint Training
2010-07 to 2011-08 - ACON Biotech (Hangzhou) Co., Ltd. - Blood Glucose R&D Engineer
2009-08 to 2010-06 - Zhejiang Hisun Pharmaceutical Co., Ltd. - Drug Formulation R&D Technician

Awards

Sanofi - Chinese Academy of Sciences Shanghai Institute of Life Sciences Outstanding Young Talent Award (2020)
Chinese Academy of Sciences President's Excellence Award (2016)

Areas of Focus	Natural product synthesis pathway mechanism analysis Microbial important physiological and metabolic molecular mechanisms
Publications	CvkR is a MerR-type transcriptional repressor of class 2 type V-K CRISPR-associated transposase systems, Nature Communications, 2023 Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1, Nature Chemical Biology, 2022 Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3, Cell Discovery, 2022 Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor, Nature Communications, 2021 Structural insights into the activation of GLP-1R by a small molecule agonist, Cell Research, 2020 C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels, Acta Pharmacologica Sinica, 2019 A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex, Science Advances, 2017 Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors, Science Advances, 2015 DWARF 53 acts as a repressor of strigolactone signalling in rice, Nature, 2013

Areas of Focus

Natural product synthesis pathway mechanism analysis
Microbial important physiological and metabolic molecular mechanisms

Publications

CvkR is a MerR-type transcriptional repressor of class 2 type V-K CRISPR-associated transposase systems, Nature Communications, 2023
Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1, Nature Chemical Biology, 2022
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3, Cell Discovery, 2022
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor, Nature Communications, 2021
Structural insights into the activation of GLP-1R by a small molecule agonist, Cell Research, 2020
C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels, Acta Pharmacologica Sinica, 2019
A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex, Science Advances, 2017
Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors, Science Advances, 2015
DWARF 53 acts as a repressor of strigolactone signalling in rice, Nature, 2013

Natural Products Synthesis Pathways Mechanism Analysis Microbial Physiology Metabolic Mechanisms Biochemistry Molecular Biology Genetic Engineering Biotechnology Bioenergy

Yanfang Wang - Tongji University

Shaojun Dai - Shanghai Normal University

Shui Wang - Shanghai Normal University

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