Areas of Focus
- 天然产物合成途径机制解析
- 微生物重要生理和代谢分子机制
Work Experience
- 2022-05到现在 - 中国科学院青岛生物能源与过程研究所 - 研究员
- 2021-04到2022-03 - 山东大学 - 研究员
- 2018-09到2021-03 - 上海药物研究所 - 副研究员
- 2016-07到2018-08 - 上海药物研究所 - 博士后
- 2014-09到2016-03 - 美国温安洛研究所 - 联合培养
- 2010-07到2011-08 - 艾康生物(杭州)技术有限公司 - 血糖研发工程师
- 2009-08到2010-06 - 浙江海正药业股份有限公司 - 药物制剂研发技术员
Academic Background & Achievements
- 2014-09到2016-03 联合培养: 美国温安洛研究所
- 2011-09到2016-07 博士学位: 上海药物研究所
- 2005-09到2009-07 学士学位: 吉林大学
Publications
- CvkR is a MerR-type transcriptional repressor of class 2 type V-K CRISPR-associated transposase systems, NATURE COMMUNICATIONS, 2023
- Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1, NATURE CHEMICAL BIOLOGY, 2022
- Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3, CELL DISCOVERY, 2022
- Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor, NATURE COMMUNICATIONS, 2021
- Structural insights into the activation of GLP-1R by a small molecule agonist, CELL RESEARCH, 2020
- C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels, ACTA PHARMACOLOGICA SINICA, 2019
- A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex, SCIENCE ADVANCES, 2017
- Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors, SCIENCE ADVANCES, 2015
- DWARF 53 acts as a repressor of strigolactone signalling in rice, NATURE, 2013
Awards
- 赛诺菲-中国科学院上海生命科学研究院优秀青年人才奖 (2020)
- 中国科学院院长优秀奖 (2016)