Professor | 马洪磊 | 数字化转型顾问

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Name

马洪磊

Contact Information

mahonglei@qibebt.ac.cn

Language ability

中文, 英文

Province

山东

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2014-09到2016-03 联合培养: 美国温安洛研究所 2011-09到2016-07 博士学位: 上海药物研究所 2005-09到2009-07 学士学位: 吉林大学
Work Experience	2022-05到现在 - 中国科学院青岛生物能源与过程研究所 - 研究员 2021-04到2022-03 - 山东大学 - 研究员 2018-09到2021-03 - 上海药物研究所 - 副研究员 2016-07到2018-08 - 上海药物研究所 - 博士后 2014-09到2016-03 - 美国温安洛研究所 - 联合培养 2010-07到2011-08 - 艾康生物（杭州）技术有限公司 - 血糖研发工程师 2009-08到2010-06 - 浙江海正药业股份有限公司 - 药物制剂研发技术员
Awards	赛诺菲－中国科学院上海生命科学研究院优秀青年人才奖 (2020) 中国科学院院长优秀奖 (2016)

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

Work Experience

Awards

Areas of Focus	天然产物合成途径机制解析微生物重要生理和代谢分子机制
Publications	CvkR is a MerR-type transcriptional repressor of class 2 type V-K CRISPR-associated transposase systems, NATURE COMMUNICATIONS, 2023 Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1, NATURE CHEMICAL BIOLOGY, 2022 Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3, CELL DISCOVERY, 2022 Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor, NATURE COMMUNICATIONS, 2021 Structural insights into the activation of GLP-1R by a small molecule agonist, CELL RESEARCH, 2020 C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels, ACTA PHARMACOLOGICA SINICA, 2019 A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex, SCIENCE ADVANCES, 2017 Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors, SCIENCE ADVANCES, 2015 DWARF 53 acts as a repressor of strigolactone signalling in rice, NATURE, 2013

Areas of Focus

天然产物合成途径机制解析
微生物重要生理和代谢分子机制

Publications

CvkR is a MerR-type transcriptional repressor of class 2 type V-K CRISPR-associated transposase systems, NATURE COMMUNICATIONS, 2023
Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1, NATURE CHEMICAL BIOLOGY, 2022
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3, CELL DISCOVERY, 2022
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor, NATURE COMMUNICATIONS, 2021
Structural insights into the activation of GLP-1R by a small molecule agonist, CELL RESEARCH, 2020
C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels, ACTA PHARMACOLOGICA SINICA, 2019
A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex, SCIENCE ADVANCES, 2017
Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors, SCIENCE ADVANCES, 2015
DWARF 53 acts as a repressor of strigolactone signalling in rice, NATURE, 2013

天然产物合成途径机制解析微生物生理代谢机制生物化学分子生物学基因工程生物技术生物能源

尹晓磊 - 同济大学

常建锋 - 同济大学

吴悠 - 同济大学

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