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Xiaoyan Pan
Life Science
University of Chinese Academy of Sciences
Hubei
Language: Chinese, English
Immunization
Infectious Diseases
Viral Infections
Drug Development
Antiviral Agents
Biopharmaceuticals
Clinical Trials
Molecular Biology
Biotechnology
Therapeutics
Areas of Focus
- Vaccines
- Small Molecule Drugs
- Therapeutic Antibodies
Work Experience
- 2020-09~Present - Wuhan Institute of Virology, Chinese Academy of Sciences - Associate Researcher
- 2018-08~2020-09 - Wuhan Institute of Virology, Chinese Academy of Sciences - Assistant Researcher
- 2016-08~2018-08 - Wuhan Institute of Virology, Chinese Academy of Sciences - Postdoctoral Researcher
- 2011-09~2016-06 - Southern Medical University - PhD
Academic Background & Achievements
- 2011-09--2016-06 PhD: Southern Medical University
- Achievement 1: Youth of the Year, 2020
- Achievement 2: Outstanding Graduate, 2016
Publications
- Impact of SARS-CoV-2 envelope protein mutations on the pathogenicity of Omicron XBB, 2nd Author, 2023
- Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2, 2nd Author, 2023
- Protection of the receptor binding domain (RBD) dimer against SARS-CoV-2 and its variants, 11th Author, 2023
- Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation, 1st Author, 2022
- Sertraline Is an Effective SARS-CoV-2 Entry Inhibitor Targeting the Spike Protein, 11th Author, 2022
- CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity, 10th Author, 2022
- High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors, 23rd Author, 2022
- Why is the SARS-CoV-2 Omicron variant milder?, 3rd Author, 2022
- PARP1 Might Substitute HSF1 to Reactivate Latent HIV-1 by Binding to Heat Shock Element, 9th Author, 2022
- Identification, optimization, and biological evaluation of 3-O-β-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion state of spike protein, Not mentioned, 2022
- SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, 4th Author, 2021
- SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO, 3rd Author, 2021
- A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates, 4th Author, 2021
- Broad-spectrum antivirals of protoporphyrins inhibit the entry of highly pathogenic emerging viruses, 2nd Author, 2021
- Drug Repurposing of Itraconazole and Estradiol Benzoate against COVID-19 by Blocking SARS-CoV-2 Spike Protein-Mediated Membrane Fusion, 2nd Author, 2021
- Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp., 3rd Author, 2021
- Axial Chiral Binaphthoquinone and Perylenequinones from the Stromata of Hypocrella bambusae Are SARS-CoV-2 Entry Inhibitors, 11th Author, 2021
- High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors, 4th Author, 2021
- The seafood Musculus senhousei shows anti-influenza A virus activity by targeting virion envelope lipids, 4th Author, 2020
- Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein, 2nd Author, 2020
- Development of horse neutralizing immunoglobulin and immunoglobulin fragments against Junin virus, 1st Author, 2020
- Immunoglobulin fragment F(ab')2 against RBD potently neutralizes SARS-CoV-2 in vitro, 1st Author, 2020
- Comprehensive Interactome Analysis Reveals that STT3B Is Required for N-Glycosylation of Lassa Virus Glycoprotein, 5th Author, 2019
- Heat shock factor 1 suppresses the HIV-induced inflammatory response by inhibiting nuclear factor-κB, 1st Author, 2018
- Novel neutralizing monoclonal antibodies against Junin virus, 1st Author, 2018
- Pr-957, a selective immunoproteasome inhibitor, reactivates latent hiv-1 through p-tefb activation mediated by hsf-1, 5th Author, 2018
- Resveratrol reactivates latent hiv through increasing histone acetylation and activating heat shock factor 1, 2nd Author, 2017
- Heat Shock Factor 1 Mediates Latent HIV Reactivation, 1st Author, 2016
- Heat Shock Protein 90 Facilitates Latent HIV Reactivation through Maintaining the Function of Positive Transcriptional Elongation Factor b (p-TEFb) under Proteasome Inhibition, 1st Author
Awards
- Youth of the Year (2020): Research Institute
- Outstanding Graduate (2016): Research Institute
